Drug General Information
Drug ID	D0Y0SY
Former ID	DIB005001
Drug Name	E-3620
Indication	Gastric motility disorder [ICD10:K22.4]		Discontinued in Phase 2	[545633]
Company	Eisai Co Ltd
Structure		Download 2D MOL 3D MOL
Canonical SMILES	c1(C(=O)N[C@@H]2CC3N(C(C2)CC3)C)c(cc(c(c1)Cl)N)O[C@H](C<br />#CC)C.Cl
CAS Number	CAS 151213-85-3
Target and Pathway
Target(s)	5-hydroxytryptamine 4 receptor	Target Info	Modulator	[1572591]
	5-HT 3 receptor	Target Info	Modulator	[1572591]
KEGG Pathway	Calcium signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Serotonergic synapse
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	5HT4 type receptor mediated signaling pathway
PathWhiz Pathway	Excitatory Neural Signalling Through 5-HTR 4 and Serotonin
Reactome	Serotonin receptors
	G alpha (s) signalling events
WikiPathways	Serotonin Receptor 4/6/7 and NR3C Signaling
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 545633	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004004)
Ref 1572591	Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.

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