Drug Information

Drug General Information
Drug ID
D0Y2IH
Former ID
DNC004038
Drug Name
LY-255283
Drug Type
Small molecular drug
Indication Asthma [ICD10:J45] Terminated [540308], [544999]
Structure
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2D MOL

3D MOL
Formula
C19H28N4O3
InChI
InChI=1S/C19H28N4O3/c1-5-15-16(13(2)24)11-14(25)12-17(15)26-10-8-6-7-9-19(3,4)18-20-22-23-21-18/h11-12,25H,5-10H2,1-4H3,(H,20,21,22,23)
InChIKey
VSDBVKWYFGKZPY-UHFFFAOYSA-N
PubChem Compound ID
35025716
PubChem Substance ID
125334705, 178100381, 252457514
Target and Pathway
Target(s) Leukotriene B4 receptor 1 Target Info Inhibitor [533797]
Leukotriene B4 receptor 2 Target Info Inhibitor [533797]
KEGG Pathway Neuroactive ligand-receptor interactionhsa04020:Calcium signaling pathway
Neuroactive ligand-receptor interaction
NetPath Pathway IL4 Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Reactome Leukotriene receptors
G alpha (q) signalling eventsR-HSA-391906:Leukotriene receptors
G alpha (q) signalling events
WikiPathways Nucleotide GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Spinal Cord Injury
GPCR ligand binding
GPCR downstream signalingWP2664:Gastrin-CREB signalling pathway via PKC and MAPK
GPCR downstream signaling
GPCRs, Other
References
Ref 540308(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3351).
Ref 544999Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001833)
Ref 533797J Med Chem. 1993 Nov 26;36(24):3978-81.o-phenylphenols: potent and orally active leukotriene B4 receptor antagonists.

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