Drug Information

Drug General Information
Drug ID
D0Y2JI
Former ID
DIB021240
Drug Name
xylazine
Synonyms
Bayer 1470; Narcoxyl; Rompun; Xylapan; Xylasol; Xylzin; BAY-VA-1470
Drug Type
Small molecular drug
Indication Discovery agent Investigative [468282]
Structure
Download
2D MOL
Formula
C12H16N2S
InChI
InChI=1S/C12H16N2S/c1-9-5-3-6-10(2)11(9)14-12-13-7-4-8-15-12/h3,5-6H,4,7-8H2,1-2H3,(H,13,14)
InChIKey
BPICBUSOMSTKRF-UHFFFAOYSA-N
PubChem Compound ID
5707
PubChem Substance ID
3712514, 6134291, 6383461, 8149776, 8153496, 10321871, 11111970, 11111971, 11335624, 11360863, 11364161, 11366723, 11369285, 11372622, 11374076, 11377447, 11461835, 11466626, 11467746, 11485051, 11486431, 11489264, 11491287, 11492054, 11495081, 14797946, 24902128, 26612232, 26679606, 26747186, 26747187, 26752277, 29224744, 47216724, 47291083, 47440194, 47440195, 47440196, 47588946, 47588947, 47662224, 47959679, 48334433, 49698575, 50051422, 50085432, 50105055, 50532260, 53837769, 57322904
Target and Pathway
Target(s) Alpha-2B adrenergic receptor Target Info Agonist [534634]
Alpha-2C adrenergic receptor Target Info Agonist [534634]
KEGG Pathway cGMP-PKG signaling pathway
Neuroactive ligand-receptor interactionhsa04022:cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
PANTHER Pathway Alpha adrenergic receptor signaling pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00002:Alpha adrenergic receptor signaling pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Reactome Adrenoceptors
Adrenaline signalling through Alpha-2 adrenergic receptor
G alpha (i) signalling events
G alpha (z) signalling eventsR-HSA-390696:Adrenoceptors
Adrenaline,noradrenaline inhibits insulin secretion
G alpha (z) signalling events
Surfactant metabolism
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Platelet Aggregation (Plug Formation)
GPCR ligand binding
GPCR downstream signalingWP58:Monoamine GPCRs
Integration of energy metabolism
GPCR downstream signaling
References
Ref 468282(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 523).
Ref 534634Ligand efficacy and potency at recombinant alpha2 adrenergic receptors: agonist-mediated [35S]GTPgammaS binding. Biochem Pharmacol. 1998 Apr 1;55(7):1035-43.

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