Drug Information

Drug General Information
Drug ID
D0Y3LL
Former ID
DIB009386
Drug Name
Taprenepag
Synonyms
Taprenepag isopropyl; CP-544326; PF-04217329; PF-4217329
Drug Type
Small molecular drug
Indication Glaucoma [ICD9: 365; ICD10:H40-H42] Phase 2 [522182], [541134]
Company
Pfizer Inc
Structure
Download
2D MOL

3D MOL
Formula
C24H22N4O5S
InChI
InChI=1S/C24H22N4O5S/c29-24(30)18-33-22-5-1-4-20(14-22)17-27(34(31,32)23-6-2-11-25-15-23)16-19-7-9-21(10-8-19)28-13-3-12-26-28/h1-15H,16-18H2,(H,29,30)
InChIKey
MFFBXYNKZHTCEY-UHFFFAOYSA-N
PubChem Compound ID
18376177
PubChem Substance ID
30159668, 96027593, 103928281, 119587250, 128587068, 135264147, 135626689, 137973065, 160703737, 178102441, 198947684, 229344782
Target and Pathway
Target(s) Prostaglandin E2receptor, EP2 subtype Target Info Agonist [531603]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
Renin secretion
Pathways in cancer
Reactome Prostanoid ligand receptors
G alpha (s) signalling events
WikiPathways Prostaglandin Synthesis and Regulation
GPCRs, Class A Rhodopsin-like
Ovarian Infertility Genes
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 522182ClinicalTrials.gov (NCT00572455) Safety and Efficacy of PF-04217329 in Patients With Glaucoma or Elevated Eye Pressure.. U.S. National Institutes of Health.
Ref 541134(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5816).
Ref 531603A phase 2, randomized, dose-response trial of taprenepag isopropyl (PF-04217329) versus latanoprost 0.005% in open-angle glaucoma and ocular hypertension. Curr Eye Res. 2011 Sep;36(9):809-17.

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