Drug Information

Drug General Information
Drug ID
D0Y3PH
Former ID
DNC006798
Drug Name
9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529785]
Structure
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2D MOL

3D MOL
Formula
C14H8N2O3
Canonical SMILES
C1=CC2=C(C=C1O)C3=C(N2)C=CC4=C3C(=O)NC4=O
InChI
1S/C14H8N2O3/c17-6-1-3-9-8(5-6)11-10(15-9)4-2-7-12(11)14(19)16-13(7)18/h1-5,15,17H,(H,16,18,19)
InChIKey
IJHAYZZOYYQESB-UHFFFAOYSA-N
PubChem Compound ID
11844342
Target and Pathway
Target(s) Serine/threonine-protein kinase Chk1 Target Info Inhibitor [528350]
Wee1-like protein kinase Target Info Inhibitor [529785]
KEGG Pathway Cell cycle
p53 signaling pathway
HTLV-I infection
Viral carcinogenesishsa04110:Cell cycle
NetPath Pathway TGF_beta_Receptor Signaling Pathway
Pathway Interaction Database Fanconi anemia pathway
p73 transcription factor network
ATR signaling pathway
Circadian rhythm pathway
p53 pathwayplk1_pathway:PLK1 signaling events
Reactome Activation of ATR in response to replication stress
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
G2/M DNA damage checkpoint
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complexR-HSA-156711:Polo-like kinase mediated events
Cyclin E associated events during G1/S transition
Cyclin A/B1 associated events during G2/M transition
G2/M DNA replication checkpoint
Cyclin A:Cdk2-associated events at S phase entry
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
Factors involved in megakaryocyte development and platelet production
WikiPathways DNA Damage Response
Signaling by SCF-KIT
ATM Signaling Pathway
Retinoblastoma (RB) in Cancer
Integrated Pancreatic Cancer Pathway
Prostate Cancer
Integrated Breast Cancer Pathway
Integrated Cancer pathway
Cell Cycle
Cell Cycle Checkpoints
miRNA Regulation of DNA Damage ResponseWP45:G1 to S cell cycle control
S Phase
Mitotic G2-G2/M phases
Mitotic G1-G1/S phases
Factors involved in megakaryocyte development and platelet production
References
Ref 529785Eur J Med Chem. 2009 Apr;44(4):1383-95. Epub 2008 Sep 30.Receptor-based 3D-QSAR studies of checkpoint Wee1 kinase inhibitors.
Ref 528350J Med Chem. 2006 Aug 10;49(16):4896-911.4-Phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione inhibitors of the checkpoint kinase Wee1. Structure-activity relationships for chromophore modification and phenyl ring substitution.
Ref 529785Eur J Med Chem. 2009 Apr;44(4):1383-95. Epub 2008 Sep 30.Receptor-based 3D-QSAR studies of checkpoint Wee1 kinase inhibitors.

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