Drug Information

Drug General Information
Drug ID
D0Y4EW
Former ID
DIB020468
Drug Name
N/OFQ-(1-13)-NH2
Synonyms
nociceptin(1-13)NH2; nociceptin/orphanin FQ(1-13)NH2; orphanin FQ(1-13)NH2
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539043]
Structure
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2D MOL

3D MOL
Formula
C61H100N22O15
InChI
InChI=1S/C61H100N22O15/c1-34(75-47(87)32-74-59(98)49(36(3)85)83-57(96)44(29-38-18-8-5-9-19-38)77-48(88)31-72-46(86)30-73-53(92)39(64)28-37-16-6-4-7-17-37)51(90)79-43(23-15-27-71-61(68)69)55(94)81-41(21-11-13-25-63)56(95)82-45(33-84)58(97)76-35(2)52(91)80-42(22-14-26-70-60(66)67)54(93)78-40(50(65)89)20-10-12-24-62/h4-9,16-19,34-36,39-45,49,84-85H,10-15,20-33,62-64H2,1-3H3,(H2,65,89)(H,72,86)(H,73,92)(H,74,98)(H,75,87)(H,76,97)(H,77,88)(H,78,93)(H,79,90)(H,80,91)(H,81,94)(H,82,95)(H,83,96)(H4,66,67,70)(H4,68,69,71)/t34-,35-,36+,39-,40-,41-,42-,43-,44-,45-,49-/m0/s1
InChIKey
RHMALYOXPBRJBG-CGUXNFSNSA-N
PubChem Compound ID
6324645
PubChem Substance ID
7980163, 16934886, 42973614, 50112453, 74723823, 103235679, 104002014, 114482019, 134341795, 135652333, 136351922, 136352708, 241182359, 241375380, 249617293
Target and Pathway
Target(s) Nociceptin receptor Target Info Agonist [534406]
KEGG Pathway Neuroactive ligand-receptor interaction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 539043(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1682).
Ref 534406Address and message sequences for the nociceptin receptor: a structure-activity study of nociceptin-(1-13)-peptide amide. J Med Chem. 1997 Jun 6;40(12):1789-93.

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