Drug Information

Drug General Information
Drug ID
D0Y5GK
Former ID
DAP001072
Drug Name
Bromodiphenhydramine
Synonyms
Amodryl; Bromanautine; Bromazin; Bromazina; Bromazine; Bromazinum; Bromdiphenhydramine; Bromdiphenhydraminum; Deserol; Histabromamine; Ambodryl hydrochloride; Bromdiphenhydramine hydrochloride; Bromdiphenylhydramine hydrochloride; Bromodiphenhydramine hydrochloride; Ambrodyl (TN); Bromazina [INN-Spanish]; Bromazine [INN:BAN]; Bromazinum [INN-Latin]; Bromo-Benadryl; Bromo-Benzdryl; Neo-Benadryl; Beta-dimethylaminoethyl p-bromobenzhydryl ether; Beta-(p-Bromobenzhydryloxy)ethyldimethylamine; 2-(p-bromo-alpha-phenylbenzyloxy)-N,N-dimethylethylamine; 2-[(4-Bromophenyl)(phenyl)methoxy]-N,N-dimethylethanamine; 2-[(4-bromophenyl)-phenylmethoxy]-N,N-dimethylethanamine; 2-{[(4-bromophenyl)(phenyl)methyl]oxy}-N,N-dimethylethanamine
Drug Type
Small molecular drug
Indication Hay fever; Cough [ICD9: 477, 786.2; ICD10:J30, R05] Approved [538416], [542139], [551871]
Therapeutic Class
Antihistamines
Structure
Download
2D MOL

3D MOL
Formula
C17H20BrNO
InChI
InChI=1S/C17H20BrNO/c1-19(2)12-13-20-17(14-6-4-3-5-7-14)15-8-10-16(18)11-9-15/h3-11,17H,12-13H2,1-2H3
InChIKey
NUNIWXHYABYXKF-UHFFFAOYSA-N
CAS Number
CAS 1808-12-4
PubChem Compound ID
2444
PubChem Substance ID
5581071, 8151630, 10505155, 15470881, 29221608, 46506082, 47662486, 47736671, 48415648, 50064225, 57321317, 75835586, 85209848, 92741730, 104300605, 128756700, 131273743, 131342039, 135115482, 137033078, 141522634, 160964569, 163141385, 170465292, 172652835, 178103708, 179225223, 215778673, 226416793, 249923974
SuperDrug ATC ID
R06AA01
SuperDrug CAS ID
cas=000118230
Target and Pathway
Target(s) Histamine H1 receptor Target Info Antagonist [537648]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
PANTHER Pathway Histamine H1 receptor mediated signaling pathway
Reactome Histamine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
IL-4 Signaling Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 538416FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 009319.
Ref 542139(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7132).
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 537648Studies on synergism between penicillins and ambodryl (bromodiphenhydramine HCl), an antihistamine with antimicrobial property. Indian J Exp Biol. 1990 Mar;28(3):253-8.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.