Drug Information

Drug General Information
Drug ID
D0Y7XC
Former ID
DNC001406
Drug Name
Talipexole
Drug Type
Small molecular drug
Indication Discovery agent Phase 4 [524901], [540844]
Structure
Download
2D MOL

3D MOL
Formula
C10H15N3S
InChI
InChI=1S/C10H15N3S/c1-2-5-13-6-3-8-9(4-7-13)14-10(11)12-8/h2H,1,3-7H2,(H2,11,12)
InChIKey
DHSSDEDRBUKTQY-UHFFFAOYSA-N
PubChem Compound ID
5374
PubChem Substance ID
7685814, 7978785, 8153304, 15195713, 15220191, 26756524, 29224426, 47291277, 47365369, 50064065, 50111389, 57322742, 78146472, 85209826, 85788358, 96025243, 103185398, 103804992, 103936559, 104309056, 117520783, 124892407, 127736594, 135016613, 136352153, 137008078, 142950048, 144205573, 162256164, 162311028, 162768352, 163882631, 170466015, 178102093, 179149471, 184546073, 198978938, 210279143, 210281465, 226433459, 251916766, 251918005
Target and Pathway
Target(s) D(2) dopamine receptor Target Info Agonist [538017]
KEGG Pathway Rap1 signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Alcoholism
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathway
Reactome Dopamine receptors
G alpha (i) signalling events
WikiPathways Hypothetical Network for Drug Addiction
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Genes and (Common) Pathways Underlying Drug Addiction
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
References
Ref 524901ClinicalTrials.gov (NCT02231905) Safety, Tolerability and Efficacy of Switching From Talipexole to Pramipexole in Patients With Parkinson's Disease. U.S. National Institutes of Health.
Ref 540844(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5442).
Ref 538017Effects of talipexole on emesis-related changes in abdominal afferent vagal activity and ileal serotonin metabolism in rats. Res Commun Mol Pathol Pharmacol. 1997 Jan;95(1):67-82.

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