Drug General Information
Drug ID
D0YB0K
Former ID
DIB018701
Drug Name
7-trans-OH-PIPAT
Synonyms
8-OH-PIPAT
Drug Type
Small molecular drug
Indication Discovery agent Investigative [543320]
Structure
Download
2D MOL
Formula
C16H22INO
InChI
InChI=1S/C16H22INO/c1-2-10-18(11-4-9-17)14-8-7-13-5-3-6-16(19)15(13)12-14/h3-6,9,14,19H,2,7-8,10-12H2,1H3/b9-4-/t14-/m1/s1
InChIKey
QBXHUZJZYDSLRH-RXTQTKKPSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) D(2) dopamine receptor Target Info Agonist [533838]
D(3) dopamine receptor Target Info Agonist [533838]
KEGG Pathway Rap1 signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Alcoholismhsa04080:Neuroactive ligand-receptor interaction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathway
Reactome Dopamine receptors
G alpha (i) signalling eventsR-HSA-390651:Dopamine receptors
G alpha (i) signalling events
WikiPathways Hypothetical Network for Drug Addiction
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Genes and (Common) Pathways Underlying Drug Addiction
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic NeuronsWP58:Monoamine GPCRs
Nicotine Activity on Dopaminergic Neurons
GPCRs, Other
References
Ref 543320(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 951).
Ref 533838Iodinated 2-aminotetralins and 3-amino-1-benzopyrans: ligands for dopamine D2 and D3 receptors. J Med Chem. 1994 Nov 25;37(24):4245-50.

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