Drug General Information
Drug ID	D0YN1E
Former ID	DNC003635
Drug Name	3,6-Di-pyridin-4-yl-pyrazolo[1,5-a]pyrimidine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[526462]
Structure		Download 2D MOL 3D MOL
Formula	C16H11N5
Canonical SMILES	C1=CN=CC=C1C2=CN3C(=C(C=N3)C4=CC=NC=C4)N=C2
InChI	1S/C16H11N5/c1-5-17-6-2-12(1)14-9-19-16-15(10-20-21(16)11-14)13-3-7-18-8-4-13/h1-11H
InChIKey	ZLISHOMLHVNDJG-UHFFFAOYSA-N
PubChem Compound ID	5329454
Target and Pathway
Target(s)	Vascular endothelial growth factor receptor 2	Target Info	Inhibitor	[526462]
	mRNA of VEGFR1	Target Info	Inhibitor	[526421]
	Vascular endothelial growth factor receptor 3	Target Info	Inhibitor	[526421]
KEGG Pathway	Ras signaling pathway
	Rap1 signaling pathway
	Cytokine-cytokine receptor interaction
	Endocytosis
	PI3K-Akt signaling pathway
	VEGF signaling pathway
	Focal adhesion
	Proteoglycans in cancerhsa04014:Ras signaling pathway
	HIF-1 signaling pathway
	Transcriptional misregulation in cancer
	Rheumatoid arthritishsa04014:Ras signaling pathway
NetPath Pathway	IL2 Signaling PathwayNetPath_9:TNFalpha Signaling Pathway
PANTHER Pathway	Angiogenesis
	VEGF signaling pathway
Pathway Interaction Database	HIF-2-alpha transcription factor network
	Beta3 integrin cell surface interactions
	Signaling events mediated by TCPTP
	SHP2 signaling
	S1P1 pathway
	VEGF and VEGFR signaling network
	Integrins in angiogenesis
	Signaling events mediated by VEGFR1 and VEGFR2
	Notch-mediated HES/HEY networkglypican_1pathway:Glypican 1 network
	S1P3 pathway
	VEGFR1 specific signals
	Signaling events mediated by VEGFR1 and VEGFR2vegf_vegfr_pathway:VEGF and VEGFR signaling network
	VEGFR3 signaling in lymphatic endothelium
Reactome	Neurophilin interactions with VEGF and VEGFR
	VEGF binds to VEGFR leading to receptor dimerization
	Integrin cell surface interactions
	EPHA-mediated growth cone collapse
	VEGFA-VEGFR2 Pathway
	VEGFR2 mediated cell proliferationR-HSA-194306:Neurophilin interactions with VEGF and VEGFR
	VEGF binds to VEGFR leading to receptor dimerizationR-HSA-195399:VEGF binds to VEGFR leading to receptor dimerization
WikiPathways	Focal Adhesion
	Nifedipine Activity
	Cardiac Progenitor Differentiation
	Signaling by VEGF
	AngiogenesisWP306:Focal Adhesion
	AngiogenesisWP1919:Signaling by VEGF
References
Ref 526462	Bioorg Med Chem Lett. 2002 Dec 16;12(24):3537-41.Optimization of a pyrazolo[1,5-a]pyrimidine class of KDR kinase inhibitors: improvements in physical properties enhance cellular activity and pharmacokinetics.
Ref 526421	Bioorg Med Chem Lett. 2002 Oct 7;12(19):2767-70.Synthesis and initial SAR studies of 3,6-disubstituted pyrazolo[1,5-a]pyrimidines: a new class of KDR kinase inhibitors.
Ref 526462	Bioorg Med Chem Lett. 2002 Dec 16;12(24):3537-41.Optimization of a pyrazolo[1,5-a]pyrimidine class of KDR kinase inhibitors: improvements in physical properties enhance cellular activity and pharmacokinetics.

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