Drug Information

Drug General Information
Drug ID
D0YR1V
Former ID
DNC004212
Drug Name
5-Butyl-8-phenyl-3H-[1,2,4]triazolo[5,1-i]purine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527055]
Structure
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2D MOL

3D MOL
Formula
C16H16N6
Canonical SMILES
CCCCC1=NC2=NC=NC2=C3N1NC(=N3)C4=CC=CC=C4
InChI
1S/C16H16N6/c1-2-3-9-12-19-15-13(17-10-18-15)16-20-14(21-22(12)16)11-7-5-4-6-8-11/h4-8,10H,2-3,9H2,1H3,(H,20,21)
InChIKey
VAZLEKNDVCJXNR-UHFFFAOYSA-N
PubChem Compound ID
11779096
Target and Pathway
Target(s) Adenosine A3 receptor Target Info Inhibitor [527055]
Adenosine A2a receptor Target Info Inhibitor [527055]
KEGG Pathway Rap1 signaling pathway
Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Parkinson's disease
Alcoholism
Pathway Interaction Database HIF-2-alpha transcription factor network
PathWhiz Pathway Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
Reactome Adenosine P1 receptors
G alpha (i) signalling eventsR-HSA-187024:NGF-independant TRKA activation
G alpha (s) signalling events
Surfactant metabolism
WikiPathways Nucleotide GPCRs
GPCRs, Class A Rhodopsin-like
GPCRs, OtherWP80:Nucleotide GPCRs
Monoamine Transport
NGF signalling via TRKA from the plasma membrane
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 527055Bioorg Med Chem Lett. 2004 May 17;14(10):2443-6.Facile synthesis of fused 1,2,4-triazolo[1,5-c]pyrimidine derivatives as human adenosine A3 receptor ligands.
Ref 527055Bioorg Med Chem Lett. 2004 May 17;14(10):2443-6.Facile synthesis of fused 1,2,4-triazolo[1,5-c]pyrimidine derivatives as human adenosine A3 receptor ligands.

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