Drug Information

Drug General Information
Drug ID
D0Z1RJ
Former ID
DIB001406
Drug Name
Adaphostin
Synonyms
NSC-680410; NSC-726814; 241127-58-2
Drug Type
Small molecular drug
Indication Chronic myelogenous leukaemia [ICD9: 205.1; ICD10:C92.1] Phase 1 [528231]
Company
Mayo Foundation
Structure
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2D MOL

3D MOL
Formula
C24H27NO4
Canonical SMILES
C12(OC(=O)c3ccc(NCc4c(ccc(c4)O)O)cc3)CC3CC(C1)CC(C2)C3
CAS Number
CAS 241127-58-2
PubChem Compound ID
387042
Target and Pathway
Target(s) Proto-oncogene c-Abl Target Info Inhibitor [526238]
KEGG Pathway ErbB signaling pathway
Ras signaling pathway
Cell cycle
Axon guidance
Neurotrophin signaling pathway
Pathogenic Escherichia coli infection
Shigellosis
Pathways in cancer
MicroRNAs in cancer
Chronic myeloid leukemia
Viral myocarditis
PANTHER Pathway Axon guidance mediated by Slit/Robo
Pathway Interaction Database p73 transcription factor network
ATM pathway
Regulation of Telomerase
Posttranslational regulation of adherens junction stability and dissassembly
Lissencephaly gene (LIS1) in neuronal migration and development
PDGFR-beta signaling pathway
Neurotrophic factor-mediated Trk receptor signaling
Validated transcriptional targets of TAp63 isoforms
p53 pathway
Regulation of retinoblastoma protein
Reactome Regulation of actin dynamics for phagocytic cup formation
CDO in myogenesis
RHO GTPases Activate WASPs and WAVEs
HDR through Single Strand Annealing (SSA)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Factors involved in megakaryocyte development and platelet production
WikiPathways Apoptosis-related network due to altered Notch3 in ovarian cancer
Fcgamma receptor (FCGR) dependent phagocytosis
ATM Signaling Pathway
Retinoblastoma (RB) in Cancer
Integrated Pancreatic Cancer Pathway
Pathogenic Escherichia coli infection
Regulation of Microtubule Cytoskeleton
Integrated Breast Cancer Pathway
Signaling by Robo receptor
Myogenesis
Factors involved in megakaryocyte development and platelet production
References
Ref 528231New strategies in chronic myeloid leukemia. Int J Hematol. 2006 May;83(4):289-93.
Ref 526238Effects of the Bcr/abl kinase inhibitors STI571 and adaphostin (NSC 680410) on chronic myelogenous leukemia cells in vitro. Blood. 2002 Jan 15;99(2):664-71.

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