Drug Information

Drug General Information
Drug ID
D0Z1WA
Former ID
DAP000944
Drug Name
Procaterol
Synonyms
Meptin; Procaterolo; Procaterolum; Procaterol Monohydrochloride; Procaterolo [DCIT]; Procaterolum [Latin]; Meptin (TN); OPC-2009; Pro-Air; Procaterol (INN); Procaterol [INN:BAN]; Procaterolum [INN-Latin]; (R*,S*)-(+-)-8-Hydroxy-5-(1-hydroxy-2-((1-methylethyl)amino)butyl)-2(1H)-quinolinone; 5-[1-hydroxy-2-(propan-2-ylamino)butyl]quinoline-2,8-diol; 8-Hydroxy-5-(1-hydroxy-2-((1-methylethyl)amino)butyl)-2(1H)-quinolinone; 8-hydroxy-5-[1-hydroxy-2-(propan-2-ylamino)butyl]-1H-quinolin-2-one
Drug Type
Small molecular drug
Indication Asthma [ICD10:J45] Approved [540402], [550747]
Therapeutic Class
Bronchodilator Agents
Structure
Download
2D MOL

3D MOL
Formula
C16H22N2O3
InChI
InChI=1S/C16H22N2O3/c1-4-12(17-9(2)3)16(21)11-5-7-13(19)15-10(11)6-8-14(20)18-15/h5-9,12,16-17,19,21H,4H2,1-3H3,(H,18,20)
InChIKey
FKNXQNWAXFXVNW-UHFFFAOYSA-N
CAS Number
CAS 72332-33-3
PubChem Compound ID
4916
PubChem Substance ID
454662, 5236618, 5924829, 8153027, 11372838, 11485136, 11489366, 11491585, 29223994, 47656602, 50043736, 50970264, 53801069, 57322523, 81065493, 85229774, 85789425, 92712757, 94569084, 96025110, 103407759, 103828139, 104307789, 117595886, 117876433, 124883616, 124886884, 125750777, 126625247, 126645806, 126656534, 126684770, 127860626, 131847254, 134932224, 135010390, 135056338, 137162755, 137619468, 152100879, 162633404, 164814604, 166233164, 179150745, 179419093, 223679895, 226396591, 251916806, 251918045, 252356196
SuperDrug ATC ID
R03AC16; R03CC08
SuperDrug CAS ID
cas=072332333
Target and Pathway
Target(s) Beta-2 adrenergic receptor Target Info Agonist [535606], [536454]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Adrenergic signaling in cardiomyocytes
Salivary secretion
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta2 adrenergic receptor signaling pathway
Pathway Interaction Database Arf6 trafficking events
Arf6 signaling events
Reactome Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Vitamin D Receptor Pathway
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 540402(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3464).
Ref 550747Drug information of Procaterol, 2008. eduDrugs.
Ref 535606beta 2-adrenoceptor polymorphism and effect of inhaled beta 2-stimulant (procaterol) on airway resistance measured by body plethysmography in healthy volunteers. Nihon Kokyuki Gakkai Zasshi. 2002 Aug;40(8):637-43.
Ref 536454Inhalation and incubation with procaterol increases diaphragm muscle contractility in mice. Allergol Int. 2007 Sep;56(3):285-91. Epub 2007 Aug 1.

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