Drug Information

Drug General Information
Drug ID
D0Z2FF
Former ID
DIB018870
Drug Name
AR244555
Synonyms
AR 244555; AR-244555
Drug Type
Small molecular drug
Indication Discovery agent Investigative [542054]
Structure
Download
2D MOL
Formula
C23H23ClF2N2O
InChI
InChI=1S/C23H23ClF2N2O/c1-2-3-11-27-12-9-23(10-13-27)15-28(20-8-7-16(24)14-17(20)23)22(29)21-18(25)5-4-6-19(21)26/h2,4-8,14H,1,3,9-13,15H2
InChIKey
QKPSTNGNDWHYCH-UHFFFAOYSA-N
PubChem Compound ID
59004159
PubChem Substance ID
139954012, 178103621, 231391908, 245674735, 252160810
Target and Pathway
Target(s) Proto-oncogene Mas Target Info Antagonist [531662]
KEGG Pathway Neuroactive ligand-receptor interaction
Renin-angiotensin system
WikiPathways ACE Inhibitor Pathway
GPCRs, Class A Rhodopsin-like
References
Ref 542054(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7042).
Ref 531662Inhibition of Mas G-protein signaling improves coronary blood flow, reduces myocardial infarct size, and provides long-term cardioprotection. Am J Physiol Heart Circ Physiol. 2012 Jan 1;302(1):H299-311.

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