Drug General Information
Drug ID	D0Z2UW
Former ID	DIB012160
Drug Name	Nicaraven
Synonyms	AVS; Antevan; Antevas
Drug Type	Small molecular drug
Indication	Cerebrovascular disorders [ICD10:I60-I69]		Phase 3	[528516]
Company	Chugai Pharmaceutical
Structure		Download 2D MOL 3D MOL
Formula	C15H16N4O2
Canonical SMILES	C(=O)(c1cnccc1)NC(CNC(=O)c1cnccc1)C
CAS Number	CAS 79455-30-4
PubChem Compound ID	71234
Target and Pathway
Target(s)	Poly [ADP-ribose] polymerase-1	Target Info	Modulator	[528516]
KEGG Pathway	Base excision repair
	NF-kappa B signaling pathway
PANTHER Pathway	FAS signaling pathway
Pathway Interaction Database	Integrin-linked kinase signaling
	Caspase Cascade in Apoptosis
	Notch-mediated HES/HEY network
Reactome	Dual Incision in GG-NER
WikiPathways	FAS pathway and Stress induction of HSP regulation
	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
	Nanoparticle triggered regulated necrosis
	Corticotropin-releasing hormone
References
Ref 528516	Inhibition of poly (ADP-ribose) polymerase as a protective effect of nicaraven in ionizing radiation- and ara-C-induced cell death. Anticancer Res. 2006 Sep-Oct;26(5A):3421-7.
Ref 528516	Inhibition of poly (ADP-ribose) polymerase as a protective effect of nicaraven in ionizing radiation- and ara-C-induced cell death. Anticancer Res. 2006 Sep-Oct;26(5A):3421-7.

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