Drug Information

Drug General Information
Drug ID
D0Z3DY
Former ID
DCL000306
Drug Name
Benzbromarone
Synonyms
Acifugan; Azubromaron; Benzbromaron; Benzbromaronratiopharm; Benzbromaronum; Benzobromarona; Besuric; Desuric; Exurate; Harolan; Hipurik; Minuric; Narcaricin; Normurat; Uricovac; Urinorm; Uroleap; Aliud Brand of Benzbromarone; Benzbromaron AL; Benzbromaron ratiopharm; Benzbromarone Aliud Brand; Benzbromarone Heumann Brand; Benzbromarone Sanfer Brand; Benzbromarone ratiopharm Brand; Heumann Brand of Benzbromarone; Ratiopharm Brand of Benzbromarone; Sanfer Brand of Benzbromarone; Sanofi Winthrop Brand of Benzbromarone; L 2214; L2214; MJ 10061; NCI85433; AL, Benzbromaron; Benzbromaron-ratiopharm; Benzbromaronum [INN-Latin]; Benzobromarona [INN-Spanish]; L 2214-Labaz; L-2214; Uroleap (TN); Benzbromarone [USAN:INN:BAN]; Methanone, (3; Benzbromarone (JP15/USAN/INN); KETONE, 3,5-DIBROMO-4-HYDROXYPHENYL 2-ETHYL-3-BENZOFURANYL; Ketone, 3,5-dibromo-4-hydroxyphenyl 2-ethyl-3-benzofuranyl; (2-Ethyl-3-benzofuranyl)-(3,5-dibrom-4-hydroxyphenyl)keton; (3,5-Dibromo-4-hydroxyphenyl)(2-ethyl-1-benzofuran-3-yl)methanone; (3,5-dibromo-4-hydroxyphenyl)-(2-ethyl-1-benzofuran-3-yl)methanone; 2-Ethyl-3-(3,5-dibrom-4-hydroxybenzoyl)benzofuran; 3, 5-Dibromo-4-hydroxyphenyl-2-ethyl-3-benzofuranyl ketone; 3,5-Dibromo-4-hydroxyphenyl-2-ethyl-3-benzofuranyl ketone; 3-(3,5-Dibromo-4-hydroxybenzoyl)-2-ethylbenzofuran; 3-[3,5-DIBROMO-4-HYDROXYBENZOYL]-2-ETHYLBENZOFURAN
Drug Type
Small molecular drug
Indication Gout [ICD9: 274.00274.1274.8274.9; ICD10:M10] Approved [551871]
Company
Labaz Laboratories
Structure
Download
2D MOL

3D MOL
Formula
C17H12Br2O3
Canonical SMILES
CCC1=C(C2=CC=CC=C2O1)C(=O)C3=CC(=C(C(=C3)Br)O)Br
InChI
1S/C17H12Br2O3/c1-2-13-15(10-5-3-4-6-14(10)22-13)16(20)9-7-11(18)17(21)12(19)8-9/h3-8,21H,2H2,1H3
InChIKey
WHQCHUCQKNIQEC-UHFFFAOYSA-N
CAS Number
CAS 3562-84-3
PubChem Compound ID
2333
PubChem Substance ID
122758, 221763, 855676, 4253342, 4572619, 7848119, 8139271, 8151561, 10320943, 10321664, 11110651, 11446236, 11458917, 11461081, 11466398, 11467518, 11486156, 11533498, 15329540, 24424558, 24891861, 26653345, 26664708, 29221503, 46386951, 47291274, 47810917, 47959937, 48185143, 48259414, 48415612, 49681786, 49698460, 49988150, 50100155, 50103990, 50804618, 56422114, 57321259, 57653945, 76715662, 85787503, 89471954, 92125465, 92308014, 92308634, 92722452, 99450936, 103513016, 103914152
ChEBI ID
ChEBI:3023
SuperDrug ATC ID
M04AB03
Target and Pathway
Target(s) Multidrug resistance-associated protein 1 Target Info Stimulator [536875]
KEGG Pathway ABC transporters
Sphingolipid signaling pathway
Vitamin digestion and absorption
MicroRNAs in cancer
NetPath Pathway IL6 Signaling Pathway
Pathway Interaction Database S1P1 pathway
Sphingosine 1-phosphate (S1P) pathway
Reactome Cobalamin (Cbl, vitamin B12) transport and metabolism
ABC-family proteins mediated transport
WikiPathways Arachidonic acid metabolism
Irinotecan Pathway
Metabolism of water-soluble vitamins and cofactors
References
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 536875Transport of diclofenac by breast cancer resistance protein (ABCG2) and stimulation of multidrug resistance protein 2 (ABCC2)-mediated drug transport by diclofenac and benzbromarone. Drug Metab Dispos. 2009 Jan;37(1):129-36. Epub 2008 Oct 9.

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