Drug Information

Drug General Information
Drug ID
D0Z3IZ
Former ID
DNC005309
Drug Name
N*6*-Cyclohexyl-N*2*-ethyl-9H-purine-2,6-diamine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527647]
Structure
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2D MOL

3D MOL
Formula
C13H20N6
Canonical SMILES
CCNC1=NC2=C(C(=N1)NC3CCCCC3)NC=N2
InChI
1S/C13H20N6/c1-2-14-13-18-11-10(15-8-16-11)12(19-13)17-9-6-4-3-5-7-9/h8-9H,2-7H2,1H3,(H3,14,15,16,17,18,19)
InChIKey
XHOVJLBZYXEITR-UHFFFAOYSA-N
PubChem Compound ID
11334464
Target and Pathway
Target(s) Adenosine A1 receptor Target Info Inhibitor [527647]
Adenosine A3 receptor Target Info Inhibitor [527647]
KEGG Pathway cGMP-PKG signaling pathway
cAMP signaling pathway
Sphingolipid signaling pathway
Neuroactive ligand-receptor interaction
Morphine addiction
NetPath Pathway TCR Signaling Pathway
RANKL Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome Adenosine P1 receptors
G alpha (i) signalling eventsR-HSA-417973:Adenosine P1 receptors
G alpha (i) signalling events
WikiPathways Nucleotide GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP80:Nucleotide GPCRs
GPCRs, Other
References
Ref 527647J Med Chem. 2005 Jul 28;48(15):4910-8."Reversine" and its 2-substituted adenine derivatives as potent and selective A3 adenosine receptor antagonists.
Ref 527647J Med Chem. 2005 Jul 28;48(15):4910-8."Reversine" and its 2-substituted adenine derivatives as potent and selective A3 adenosine receptor antagonists.

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