Drug Information

Drug General Information
Drug ID
D0Z4EI
Former ID
DIB010980
Drug Name
Mifepristone
Synonyms
Mifedren; HRA-052015; Mifepristone (Cushing's disease); ACTH modulator (Cushing's disease), HRA; Adrenocorticotropic hormone modulator (Cushing's disease), HRA Pharma; Mifepristone (Cushing's disease), HRA pharma
Drug Type
Small molecular drug
Indication Cushing's disease [ICD9: 255; ICD10:E24.0] Approved [525064], [539846], [551871]
Company
HRA Pharma
Structure
Download
2D MOL

3D MOL
Formula
C29H35NO2
InChI
InChI=1S/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h6-7,9-10,17,24-26,32H,8,11-14,16,18H2,1-4H3/t24-,25+,26-,28-,29-/m0/s1
InChIKey
VKHAHZOOUSRJNA-GCNJZUOMSA-N
PubChem Compound ID
55245
PubChem Substance ID
9854, 610895, 827617, 7847651, 7885329, 7979988, 8184037, 10321543, 11466327, 11467447, 11486193, 11533034, 12013919, 12146248, 14758749, 14905326, 17405362, 24278572, 26752199, 26759172, 34719152, 46386955, 46505795, 46518693, 47573358, 47720589, 47795017, 47795018, 48018884, 48318385, 48393908, 48416281, 49698423, 49835339, 49965772, 50124354, 50576278, 53777907, 53788556, 56312231, 56313355, 56313657, 56313765, 56352854, 56424093, 57313727, 85752924, 85789352, 90341299, 92125204
Target and Pathway
Target(s) Glucocorticoid receptor Target Info Modulator [528847]
KEGG Pathway Neuroactive ligand-receptor interaction
NetPath Pathway IL2 Signaling Pathway
TCR Signaling Pathway
Pathway Interaction Database Regulation of nuclear SMAD2/3 signaling
Signaling events mediated by HDAC Class II
FOXA2 and FOXA3 transcription factor networks
Glucocorticoid receptor regulatory network
Regulation of Androgen receptor activity
AP-1 transcription factor network
Reactome BMAL1:CLOCK,NPAS2 activates circadian gene expression
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
SIDS Susceptibility Pathways
Nuclear Receptors Meta-Pathway
Endoderm Differentiation
Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
Adipogenesis
Circadian Clock
Nuclear Receptors
References
Ref 525064ClinicalTrials.gov (NCT02342002) Mifepristone and Misoprostol Versus Misoprostol Alone for Missed Abortion: A Randomized-controlled Trial. U.S. National Institutes of Health.
Ref 539846(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2805).
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 528847The glucocorticoid agonist activities of mifepristone (RU486) and progesterone are dependent on glucocorticoid receptor levels but not on EC50 values. Steroids. 2007 Jun;72(6-7):600-8. Epub 2007 Apr7.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.