Drug Information

Drug General Information
Drug ID
D0Z7AW
Former ID
DNC012679
Drug Name
CP-293019
Drug Type
Small molecular drug
Indication Discovery agent Terminated [543340], [546533]
Structure
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2D MOL

3D MOL
Formula
C19H22F2N4O
InChI
InChI=1S/C19H22F2N4O/c20-15-2-5-18(6-3-15)26-13-14-1-4-17-12-25(8-7-24(17)11-14)19-22-9-16(21)10-23-19/h2-3,5-6,9-10,14,17H,1,4,7-8,11-13H2/t14-,17+/m1/s1
InChIKey
QXWNESOGWFJDFR-PBHICJAKSA-N
PubChem Compound ID
9820261
PubChem Substance ID
14779023, 14876778, 24123943, 44856221, 80342221, 103259867, 103963187, 129090729, 134349884, 135650126, 137053975, 232527818
Target and Pathway
Target(s) 5-hydroxytryptamine 1A receptor Target Info Inhibitor [534783]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 543340(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 977).
Ref 546533Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008823)
Ref 534783Bioorg Med Chem Lett. 1998 Apr 7;8(7):725-30.Synthesis, SAR and pharmacology of CP-293,019: a potent, selective dopamine D4 receptor antagonist.

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