Drug General Information
Drug ID	D0Z8EI
Former ID	DNC004022
Drug Name	6-Allyloxy-9H-purin-2-ylamine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[525899]
Structure		Download 2D MOL 3D MOL
Formula	C8H9N5O
Canonical SMILES	C=CCOC1=NC(=NC2=C1NC=N2)N
InChI	1S/C8H9N5O/c1-2-3-14-7-5-6(11-4-10-5)12-8(9)13-7/h2,4H,1,3H2,(H3,9,10,11,12,13)
InChIKey	HJMGFQNIHIHSCQ-UHFFFAOYSA-N
PubChem Compound ID	179571
Target and Pathway
Target(s)	Methylated-DNA--protein-cysteine methyltransferase	Target Info	Inhibitor	[525899]
WikiPathways	DNA Damage Reversal
References
Ref 525899	J Med Chem. 2000 Nov 2;43(22):4071-83.Resistance-modifying agents. 8. Inhibition of O(6)-alkylguanine-DNA alkyltransferase by O(6)-alkenyl-, O(6)-cycloalkenyl-, and O(6)-(2-oxoalkyl)guanines and potentiation of temozolomide cytotoxicity in vitro by O(6)-(1-cyclopentenylmethyl)guanine.
Ref 525899	J Med Chem. 2000 Nov 2;43(22):4071-83.Resistance-modifying agents. 8. Inhibition of O(6)-alkylguanine-DNA alkyltransferase by O(6)-alkenyl-, O(6)-cycloalkenyl-, and O(6)-(2-oxoalkyl)guanines and potentiation of temozolomide cytotoxicity in vitro by O(6)-(1-cyclopentenylmethyl)guanine.

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