Drug Information

Drug General Information
Drug ID
D0Z9QR
Former ID
DAP000703
Drug Name
Zalcitabine
Synonyms
DdC; DdCyd; Dideoxycytidine; HIVID; Zalcitibine; D 5782; DDC (DDC); DdC & Interferon alpha; DdC & sCD4; DdC (Antiviral); Hivid (TN); Hivid(TM); Interferon AD + ddC; KS-1130; SRI-7707; Beta-D-DDC; DS-4152 & ddC; DdC & GM-CSF; DdC & IFN-alpha; DdC & NP (from PHCA or HSA); PC-SOD & ddC; Ro 24-2027/000; Zalcitabine [USAN:INN:BAN]; Hivid, Dideoxycytidine, NSC 606170, Zalcitabine; Ro-24-2027/000; Zalcitabine (JAN/USP/INN); Beta-D-2',3'-Dideoxycytidine; Cytidine, 2',3'-dideoxy & Interferon alpha; Sulfated polysaccharide-peptidoglycan DS-4152 & 2',3'-Dideoxycytidine; Cytidine, 2',3'-dideoxy-& Colony-stimulating factor; Beta-D-2',3'-Dideoxycytidine & Granulocyte-macrophage colony-stimulating factor; Lecithinized superoxide dismutase & .beta.-D-2',3'-Dideoxycytidine; 1-(2,3-Dideoxy-beta-D-ribofuranosyl)cytosine; 2',3'-DIDEOXYCYTIDINE; 2',3'-Dideoxycytidine & Interferon-alpha; 2',3'-Dideoxycytidine & Nanoparticles (from human serum albumin or polyhexylcyanoacrylate); 2',3'-Dideoxycytidine & sCD4(soluble recombinant protein); 2,3-dideoxycytidine; 3'-Azido-3'-deoxythymidine/2',3'-Dideoxycytidine; 4-amino-1-[(2R,5S)-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one; 4-amino-1-[(2R,5S)-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2(1H)-one
Drug Type
Small molecular drug
Indication Human immunodeficiency virus infection [ICD9: 279.3; ICD10:B20-B26] Approved [468060], [536361]
Therapeutic Class
Anti-HIV Agents
Company
Hoffmann-La Roche pharmaceutical company
Structure
Download
2D MOL

3D MOL
Formula
C9H13N3O3
InChI
InChI=1S/C9H13N3O3/c10-7-3-4-12(9(14)11-7)8-2-1-6(5-13)15-8/h3-4,6,8,13H,1-2,5H2,(H2,10,11,14)/t6-,8+/m0/s1
InChIKey
WREGKURFCTUGRC-POYBYMJQSA-N
CAS Number
CAS 7481-89-2
PubChem Compound ID
24066
PubChem Substance ID
9416, 595891, 596441, 596607, 596679, 601537, 602107, 878108, 3259589, 7847478, 7980904, 8167576, 11467065, 11468185, 11486840, 11504751, 11528334, 11532889, 14797711, 15171927, 17389522, 17404923, 22391526, 22431601, 24278377, 24862834, 25819962, 26719633, 26752752, 26752753, 29291163, 46386814, 46488030, 46507879, 47216920, 47216921, 47589142, 48185139, 48334652, 48416706, 48422195, 48422429, 48423540, 48424478, 49681781, 49693297, 49699414, 49734166, 50105404, 50105405
SuperDrug ATC ID
J05AF03
SuperDrug CAS ID
cas=007481892
Target and Pathway
Target(s) HIV reverse transcriptase Target Info Inhibitor [535977]
References
Ref 468060(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4828).
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 535977Primer unblocking by HIV-1 reverse transcriptase and resistance to nucleoside RT inhibitors (NRTIs). Int J Biochem Cell Biol. 2004 Sep;36(9):1687-705.

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