Drug Information

Drug General Information
Drug ID
D0ZC4S
Former ID
DNC004356
Drug Name
(1H-Imidazol-2-yl)-quinoxalin-6-yl-amine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [534315]
Structure
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2D MOL

3D MOL
Formula
C11H9N5
Canonical SMILES
C1=CC2=NC=CN=C2C=C1NC3=NC=CN3
InChI
1S/C11H9N5/c1-2-9-10(13-4-3-12-9)7-8(1)16-11-14-5-6-15-11/h1-7H,(H2,14,15,16)
InChIKey
CDFWKVORAWOKDO-UHFFFAOYSA-N
PubChem Compound ID
10632290
Target and Pathway
Target(s) Alpha-2A adrenergic receptor Target Info Inhibitor [534315]
Alpha-2C adrenergic receptor Target Info Inhibitor [534315]
KEGG Pathway cGMP-PKG signaling pathway
Neuroactive ligand-receptor interactionhsa04022:cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
PANTHER Pathway Alpha adrenergic receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Reactome Adrenoceptors
Adrenaline signalling through Alpha-2 adrenergic receptor
Adrenaline,noradrenaline inhibits insulin secretion
G alpha (i) signalling events
G alpha (z) signalling events
Surfactant metabolismR-HSA-390696:Adrenoceptors
Surfactant metabolism
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Platelet Aggregation (Plug Formation)
Integration of energy metabolism
GPCR ligand binding
GPCR downstream signalingWP58:Monoamine GPCRs
GPCR downstream signaling
References
Ref 534315J Med Chem. 1997 Jan 3;40(1):18-23.Synthesis and evaluation of 2-(arylamino)imidazoles as alpha 2-adrenergic agonists.
Ref 534315J Med Chem. 1997 Jan 3;40(1):18-23.Synthesis and evaluation of 2-(arylamino)imidazoles as alpha 2-adrenergic agonists.

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