Drug Information

Drug General Information
Drug ID
D0ZD2M
Former ID
DCL000576
Drug Name
MLN4924
Drug Type
Small molecular drug
Indication Advanced malignancies [ICD9: 140-229; ICD10:C00-C96] Phase 1 [537215]
Company
Takeda
Structure
Download
2D MOL

3D MOL
Formula
C21H25N5O4S
Canonical SMILES
C1CC2=CC=CC=C2C1NC3=NC=NC4=C3C=CN4C5CC(C(C5)O)COS(=O)(=<br />O)N
InChI
1S/C21H25N5O4S/c22-31(28,29)30-11-14-9-15(10-19(14)27)26-8-7-17-20(23-12-24-21(17)26)25-18-6-5-13-3-1-2-4-16(13)18/h1-4,7-8,12,14-15,18-19,27H,5-6,9-11H2,(H2,22,28,29)(H,23,24,25)/t14-,15+,18-,19-/m0/s1
InChIKey
MPUQHZXIXSTTDU-QXGSTGNESA-N
PubChem Compound ID
16720766
PubChem Substance ID
26674965, 29140237, 30578056, 87349941, 104247347, 136350021, 138250801, 139830203, 152186818, 152258892, 160647740, 162108926, 164042007, 170482619, 172232506, 177748638, 186013487, 198950004, 223704989, 224472339, 226552040, 248256090, 252160673, 252215832, 252441258, 252472523
Drug Resistance Mutation (DRM)
DRM DRM Info
Target and Pathway
Target(s) NEDD8-activating enzyme Target Info Modulator
References
Ref 537215Drug discovery: Fresh target for cancer therapy. Nature. 2009 Apr 9;458(7239):709-10.

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