Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0ZJ1C
|
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| Former ID |
DAP001340
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| Drug Name |
(S)-(+)-Dimethindene maleate
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| Drug Type |
Small molecular drug
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| Indication | Pruritus [ICD9: 698; ICD10:L29] | Approved | [535933] | ||
| Therapeutic Class |
Antiinflammatory Agents
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| Structure |
|
Download2D MOL |
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| Formula |
C24H28N2O4
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| Canonical SMILES |
CC(C1=CC=CC=N1)C2=C(CC3=CC=CC=C32)CCN(C)C.C(=CC(=O)O)C(<br />=O)O
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| InChI |
1S/C20H24N2.C4H4O4/c1-15(19-10-6-7-12-21-19)20-17(11-13-22(2)3)14-16-8-4-5-9-18(16)20;5-3(6)1-2-4(7)8/h4-10,12,15H,11,13-14H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t15-;/m1./s1
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| InChIKey |
SWECWXGUJQLXJF-HFNHQGOYSA-N
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| CAS Number |
CAS 121367-05-3
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Histamine H1 receptor | Target Info | Antagonist | [535859], [535933], [537168], [537884] | |
| PANTHER Pathway | Histamine H1 receptor mediated signaling pathway | ||||
| References | |||||
| Ref 535859 | Effects of dimethindene maleate nasal spray on the quality of life in seasonal allergic rhinitis. Rhinology. 2003 Sep;41(3):159-66. | ||||
| Ref 535933 | Prescription and safety of dimethindene maleate micropellet capsules in Hungary. Orv Hetil. 2004 Feb 15;145(7):327-9. | ||||
| Ref 537168 | Analytical method for simultaneously measuring ex vivo drug receptor occupancy and dissociation rate: application to (R)-dimethindene occupancy of central histamine H1 receptors. J Recept Signal Transduct Res. 2009;29(2):84-93. | ||||
| Ref 537884 | Inhibition by histamine H1 receptor antagonists of endogenous glibenclamide-sensitive K+ channels in follicle-enclosed Xenopus oocytes. Eur J Pharmacol. 1994 Jan 1;266(1):99-102. | ||||
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