Drug General Information
Drug ID
D0ZT8A
Former ID
DIB016023
Drug Name
T3D-959
Indication Alzheimer disease [ICD9: 331; ICD10:G30] Phase 1/2 [525327]
Company
T3d therapeutics
Target and Pathway
Target(s) Peroxisomeproliferator activated receptor delta Target Info Modulator
Peroxisome proliferator activated receptor gamma Target Info Modulator
KEGG Pathway PPAR signaling pathway
Wnt signaling pathway
Pathways in cancer
Acute myeloid leukemiahsa03320:PPAR signaling pathway
AMPK signaling pathway
Osteoclast differentiation
Huntington's disease
Transcriptional misregulation in cancer
Thyroid cancer
NetPath Pathway IL2 Signaling PathwayNetPath_13:IL1 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
Leptin Signaling Pathway
PANTHER Pathway Wnt signaling pathwayP06959:CCKR signaling map ST
Pathway Interaction Database Presenilin action in Notch and Wnt signaling
RXR and RAR heterodimerization with other nuclear receptorwnt_noncanonical_pathway:Noncanonical Wnt signaling pathway
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
Signaling events mediated by HDAC Class I
RXR and RAR heterodimerization with other nuclear receptor
Regulation of retinoblastoma protein
Reactome Import of palmitoyl-CoA into the mitochondrial matrix
Regulation of pyruvate dehydrogenase (PDH) complex
Nuclear Receptor transcription pathwayR-HSA-1989781:PPARA activates gene expression
Transcriptional regulation of white adipocyte differentiation
Nuclear Receptor transcription pathway
WikiPathways Wnt Signaling Pathway and Pluripotency
Nuclear Receptors in Lipid Metabolism and Toxicity
NRF2 pathway
Nuclear Receptors Meta-Pathway
Vitamin D Receptor Pathway
Ectoderm Differentiation
Adipogenesis
Nuclear ReceptorsWP363:Wnt Signaling Pathway Netpath
Differentiation of white and brown adipocyte
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Transcriptional Regulation of White Adipocyte Differentiation
SREBP signalling
Nuclear Receptors
References
Ref 525327ClinicalTrials.gov (NCT02560753) Feasibility Study in Subjects With Mild to Moderate Alzheimer's Disease.

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