Drug Information

Drug General Information
Drug ID
D0ZX1P
Former ID
DNC003938
Drug Name
FADROZOLE
Drug Type
Small molecular drug
Indication Breast cancer [ICD9: 174, 175; ICD10:C50] Approved [543063], [544743], [551871]
Structure
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2D MOL

3D MOL
Formula
C14H13N3
InChI
InChI=1S/C14H13N3/c15-8-11-4-6-12(7-5-11)14-3-1-2-13-9-16-10-17(13)14/h4-7,9-10,14H,1-3H2
InChIKey
CLPFFLWZZBQMAO-UHFFFAOYSA-N
CAS Number
CAS 102676-31-3
PubChem Compound ID
59693
PubChem Substance ID
8186457, 11109352, 12013788, 15196027, 43117201, 49888726, 50398647, 53786956, 56314437, 57313957, 93307948, 96024635, 103168211, 104318833, 117514615, 125329682, 126652685, 126730661, 127643009, 134222411, 134341676, 135019085, 137029080, 142971172, 152043822, 152225225, 152344559, 160813913, 162011755, 162355266, 163373181, 164297405, 172888059, 174525827, 177748984, 179149485, 204397132, 223704884, 224404574, 226413559, 249755678, 249848613, 250207817, 251971192, 252034695, 252166523
Target and Pathway
Target(s) Cytochrome P450 19 Target Info Inhibitor [527856]
Cytochrome P450 11B1, mitochondrial Target Info Inhibitor [530679]
BioCyc Pathway Superpathway of steroid hormone biosynthesis
Estradiol biosynthesis II
Estradiol biosynthesis IPWY-7305:Superpathway of steroid hormone biosynthesis
Glucocorticoid biosynthesis
Mineralocorticoid biosynthesis
KEGG Pathway Steroid hormone biosynthesis
Metabolic pathways
Ovarian steroidogenesishsa00140:Steroid hormone biosynthesis
NetPath Pathway FSH Signaling Pathway
PANTHER Pathway Androgen/estrogene/progesterone biosynthesis
PathWhiz Pathway Androgen and Estrogen MetabolismPW000141:Steroidogenesis
Reactome Endogenous sterolsR-HSA-194002:Glucocorticoid biosynthesis
Endogenous sterols
WikiPathways Metapathway biotransformation
Tryptophan metabolism
Oxidation by Cytochrome P450
Ovarian Infertility Genes
Metabolism of steroid hormones and vitamin D
FSH signaling pathway
Integrated Breast Cancer Pathway
Phase 1 - Functionalization of compoundsWP702:Metapathway biotransformation
Corticotropin-releasing hormone
References
Ref 543063(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8311).
Ref 544743Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000824)
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 527856J Med Chem. 2005 Nov 17;48(23):7282-9.Enantioselective nonsteroidal aromatase inhibitors identified through a multidisciplinary medicinal chemistry approach.
Ref 530679J Med Chem. 2010 Feb 25;53(4):1712-25.Synthesis, biological evaluation, and molecular modeling of 1-benzyl-1H-imidazoles as selective inhibitors of aldosterone synthase (CYP11B2).

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