Drug General Information
Drug ID	D0ZX2D
Former ID	DIB006154
Drug Name	11C-6-Me-BTA-1
Synonyms	Carbon-11-6-Me-BTA-1; 11C-BTA-1
Indication	Alzheimer disease [ICD9: 331; ICD10:G30]		Phase 1	[525385]
Company	University of Pittsburgh
Structure		Download 2D MOL 3D MOL
Canonical SMILES	c1(nc2c(s1)cc(cc2)C)c1ccc(N[11CH3])cc1
CAS Number	CAS 370099-48-2
Target and Pathway
Target(s)	Amyloid beta A4 protein	Target Info	Modulator	[529223]
KEGG Pathway	Notch signaling pathway
	Alzheimer's disease
Reactome	Nuclear signaling by ERBB4
	Degradation of the extracellular matrix
	Regulated proteolysis of p75NTR
	NRIF signals cell death from the nucleus
	Activated NOTCH1 Transmits Signal to the Nucleus
	Constitutive Signaling by NOTCH1 PEST Domain Mutants
	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
	EPH-ephrin mediated repulsion of cells
WikiPathways	Notch Signaling Pathway
	Signaling by ERBB4
	Signaling by NOTCH3
	Signaling by NOTCH4
	Signaling by NOTCH1
	Signaling by NOTCH2
	Notch Signaling Pathway
	Alzheimers Disease
	Signalling by NGF
References
Ref 525385	List of drugs in development for neurodegenerative diseases: update October 2011. Neurodegener Dis. 2012;9(4):210-83.
Ref 529223	Radiosynthesis and evaluation of [11C]BTA-1 and [11C]3'-Me-BTA-1 as potential radiotracers for in vivo imaging of beta-amyloid plaques. Nuklearmedizin. 2007;46(6):271-80.

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