Drug Information

Drug General Information
Drug ID
D0ZX7I
Former ID
DIB014632
Drug Name
SR-57227
Synonyms
SR-57227A
Drug Type
Small molecular drug
Indication Major depressive disorder [ICD9: 296.2, 296.3, 710.0; ICD10:F32, F33, M32] Discontinued in Phase 2 [467653], [544942]
Company
Sanofi
Structure
Download
2D MOL

3D MOL
Formula
C10H14ClN3
InChI
InChI=1S/C10H14ClN3/c11-9-2-1-3-10(13-9)14-6-4-8(12)5-7-14/h1-3,8H,4-7,12H2
InChIKey
WPVVMKYQOMJPIN-UHFFFAOYSA-N
PubChem Compound ID
131747
PubChem Substance ID
7481999, 7980663, 10242949, 11111781, 11113955, 15195750, 26752102, 29310041, 47500606, 47721698, 48170518, 50104756, 57343891, 80006403, 85787816, 90340574, 103303610, 104011943, 104171236, 104375818, 124750211, 124881405, 124881406, 124881407, 129616753, 143286332, 162637546, 163583375, 178101133, 179235770, 218905729, 224847731, 230183040, 245703635, 249983985
Target and Pathway
Target(s) 5-Hydroxytryptamine 3 receptor Target Info Modulator [534182]
References
Ref 467653(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4316).
Ref 544942Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001602)
Ref 534182Antidepressant-like effects of SR 57227A, a 5-HT3 receptor agonist, in rodents. J Neural Transm Gen Sect. 1995;102(2):83-90.

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