Drug General Information
Drug ID
DXB99Y
Drug Name
(R)-6-Hydroxycarbamoyl-5-((S)-1-methylcarbamoyl-2-phenyl-ethylcarbamoyl)-hexanoic acid
Synonyms
CHEMBL85933
Indication Discovery agent Investigative [1587926]
Formula
C18H25N3O6
Canonical SMILES
CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCC(=O)O)CC(=O)NO
InChI
InChI=1S/C18H25N3O6/c1-19-18(26)14(10-12-6-3-2-4-7-12)20-17(25)13(11-15(22)21-27)8-5-9-16(23)24/h2-4,6-7,13-14,27H,5,8-11H2,1H3,(H,19,26)(H,20,25)(H,21,22)(H,23,24)/t13-,14+/m1/s1
InChIKey
NBDGYUOAVSOSOD-KGLIPLIRSA-N
Target and Pathway
Target(s) Interstitial collagenase Target Info [1587926]
Neutrophil collagenase Target Info [1587926]
KEGG Pathway PPAR signaling pathway
Pathways in cancer
Bladder cancer
Rheumatoid arthritis
NetPath Pathway IL1 Signaling Pathway
EGFR1 Signaling Pathway
TWEAK Signaling Pathway
Wnt Signaling Pathway
PANTHER Pathway Alzheimer disease-presenilin pathway
Plasminogen activating cascadeP00004:Alzheimer disease-presenilin pathway
Pathway Interaction Database Endothelins
Validated transcriptional targets of AP1 family members Fra1 and Fra2
Glucocorticoid receptor regulatory network
AP-1 transcription factor network
Syndecan-1-mediated signaling events
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Basigin interactions
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)R-HSA-1442490:Collagen degradation
WikiPathways TGF beta Signaling Pathway
Bladder Cancer
Activation of Matrix Metalloproteinases
Degradation of collagen
Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis
Oncostatin M Signaling Pathway
Prostate Cancer
Integrated Breast Cancer Pathway
Integrated Cancer pathway
Cell surface interactions at the vascular wall
Matrix MetalloproteinasesWP2769:Activation of Matrix Metalloproteinases
Matrix Metalloproteinases
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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