Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Ftase --- FPTase | 6-[3-(4-cyano-phenyl)-3-hydroxy-3-(3-methyl-3H-imidazol-4-yl)-prop-1-ynyl]-3'-ethoxy-biphenyl-3-carbonitrile | Drug Info |
| mTOR --- DNPK1 | 2-(2-Methyl-morpholin-4-yl)-benzo[h]chromen-4-one | Drug Info |
| VEGFR2 --- CSrc | Benzofuran-7-yl-[6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinazolin-4-yl]-amine | Drug Info |
| Ftase --- FPTase | 4-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-piperazine-1-carboxylic acid benzyl ester | Drug Info |
| mTOR --- PI3K gamma | 2-(N-Methylindol-3-ylmethylene)-4,6-dihydroxybenzofuran-3(2H)-one | Drug Info |
| VEGFR2 --- CSrc | 6-(2,6-dimethylphenyl)-2-((3,4,5-trimethoxyphenyl)amino)pyrimido-[5',4':5,6]pyrimido[1,2-a]benzimidazol-5(6H)-one | Drug Info |
| Ftase --- FPTase | 5-[(4-Cyano-phenyl)-hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]-2'-methyl-biphenyl-2-carbonitrile | Drug Info |
| mTOR --- PI3K gamma | 1-[4-(3-Isopropyl-7-morpholin-4-yl-3H-[1,2,3]-triazolo[4,5-d]pyrimidin-5-yl)phenyl]-3-(4-morpholin-4-ylphenyl)urea | Drug Info |
| VEGFR2 --- EGFR3 | (2E)-4-(dimethylamino)-N-(4-{[3,6-dioxo-4-(pyridin-2-ylmethoxy)cyclohexa-1,4-dien-1-yl]amino}-7-ethoxyquinazolin-6-yl)but-2-enamide | Drug Info |
| Ftase --- FPTase | 2-(1-Benzenesulfonyl-piperidin-4-yl)-1-[4-((R)-3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidin-1-yl]-ethanone | Drug Info |
| mTOR --- PI3K gamma | 1-(4-(3,3-dimethylpiperazine-1-carbonyl)phenyl)-3-(4-(4-methoxy-6-morpholino-1,3,5-triazin-2-yl)phenyl)urea | Drug Info |
| VEGFR2 --- FGFR1 | 1-tert-Butyl-3-[3-(3,5-dimethoxy-phenyl)-7-(3-phenoxy-propylamino)-[1,6]naphthyridin-2-yl]-urea | Drug Info |
| Ftase --- FPTase | 15,16,18-trimethyl-17-oxo-(16R)-2-oxa-9,11,15,18-tetraazapentacyclo[17.6.2.13,7.09,13.023,27]octacosa-1(26),3,5,7(28),10,12,19(27),20,22,24-decaen-4-yl cyanide | Drug Info |
| mTOR --- PI3K gamma | 3-(6-morpholino-9-(piperidin-4-yl)-9H-purin-2-yl)phenol | Drug Info |
| VEGFR2 --- TEK | 4-methyl-3-(3-(pyrimidin-4-yl)pyridin-2-yloxy)-N-(4-(trifluoromethyl)phenyl)benzamide | Drug Info |
| Ftase --- FPTase | 19-methyl-15,18-dioxo-2-oxa-9,11,16,19-tetraazapentacyclo[18.6.2.13,7.09,13.024,28]nonacosa-1(27),3,5,7(29),10,12,20(28),21,23,25-decaen-4-yl cyanide | Drug Info |
| NET --- SERT | 3-methoxy-5,6-dihydrobenzo[c]acridin-7-amine | Drug Info |
| VEGFR2 --- TEK | 7-Cyclopentyl-5-(3-phenoxy-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine | Drug Info |
| Ftase --- FPTase | 2-(2-{(S)-1-[(S)-1-((S)-1-Carboxy-2-hydroxy-ethylcarbamoyl)-3-methyl-butylcarbamoyl]-2-methyl-propylcarbamoyl}-ethyl)-tetradecanoic acid | Drug Info |
| NET --- SERT | 3-Piperidin-4-ylmethyl-1H-indole | Drug Info |
| VEGFR2 --- TEK | 4-methyl-3-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)-N-(2-(piperidin-1-yl)-5-(trifluoromethyl)phenyl)benzamide | Drug Info |
| Ftase --- FPTase | (2S)-methyl 2-(2-(3-(3-(1H-imidazol-5-yl)propyl)-5-methyl-5-(naphthalen-1-yl)-2,4-dioxoimidazolidin-1-yl)acetamido)-4-(methylthio)butanoate | Drug Info |
| NPKCdelta --- NPKCtheta | 2-(4-((dimethylamino)methyl)phenyl)-4-(4-methyl-1H-indol-5-ylamino)thieno[2,3-b]pyridine-5-carbonitrile | Drug Info |
| VEGFR2 --- TEK | 19-methyl-3-(2-methylpropyl)-3,13,19,20-tetraazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,21}]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-14-one | Drug Info |
| Ftase --- FPTase | 1-[(2R,3R)-6-Chloro-3-(5-chloro-thiophen-2-ylmethoxy)-2,3-dihydro-benzo[b]thiophen-2-ylmethyl]-1H-imidazole | Drug Info |
| NPKCdelta --- NPKCtheta | 5-(5-((4-cyclopentylpiperazin-1-yl)methyl)furan-3-yl)-4-(4-methyl-1H-indol-5-ylamino)nicotinonitrile | Drug Info |
| VEGFR2 --- TEK | 1-(2-methoxy-5-(trifluoromethyl)phenyl)-3-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyrazin-6-yl)phenyl)urea | Drug Info |
| Ftase --- FPTase | ethyl 2-(5-methyl-3-(3-(1-methyl-1H-imidazol-5-yl)propyl)-5-(naphthalen-1-yl)-2,4-dioxoimidazolidin-1-yl)acetate | Drug Info |
| NPKCdelta --- NPKCtheta | (R)-2-(3-(3-(dimethylamino)pyrrolidin-1-yl)-3-oxoprop-1-enyl)-4-(4-methyl-1H-indol-5-ylamino)thieno[2,3-b]pyridine-5-carbonitrile | Drug Info |
| VEGFR2 --- TEK | SID124350139 | Drug Info |
| Ftase --- FPTase | 4-[1-Amino-1-(3-methyl-3H-imidazol-4-yl)-ethyl]-2-{3-[1-methyl-2-oxo-3-(3,3,3-trifluoro-propyl)-azepan-3-yl]-phenoxy}-benzonitrile | Drug Info |
| NPKCdelta --- NPKCtheta | 5-(5-((2,3-dihydroxypropylamino)methyl)benzofuran-2-yl)-4-(4-methyl-1H-indol-5-ylamino)nicotinonitrile | Drug Info |
| VEGFR2 --- VEGFR1 | 6-(4-Methoxy-phenyl)-3-pyridin-3-yl-pyrazolo[1,5-a]pyrimidine | Drug Info |
| Ftase --- FPTase | [1-(3H-Imidazol-4-ylmethyl)-4-naphthalen-1-yl-1H-pyrrol-3-yl]-piperidin-1-yl-methanone | Drug Info |
| NPKCdelta --- NPKCtheta | 5-(5-((4-isopropylpiperazin-1-yl)methyl)furan-3-yl)-4-(4-methyl-1H-indol-5-ylamino)nicotinonitrile | Drug Info |
| VEGFR2 --- VEGFR1 | 2-(pyridin-4-ylmethylamino)-N-(quinolin-3-yl)benzamide | Drug Info |
| GSK --- VEGFR | 4-amino-5-(4-(benzenesulfonylamino)-phenyl)-6-(3-pyridyl)-furo[2,3-d]pyrimidine | Drug Info |
| EGFR3 --- HER2 | N-[4-(3-Bromo-phenylamino)-pyrido[3,4-d]pyrimidin-6-yl]-acrylamide | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(1H-indol-4-ylamino)-5-(4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)nicotinonitrile | Drug Info |
| VEGFR2 --- VEGFR1 | N-(3,5-bis(trifluoromethyl)phenyl)-1-methyl-4-(pyridin-4-ylmethylamino)-1H-pyrazole-5-carboxamide | Drug Info |
| H3 --- SERT | 3-(3-bromophenoxy)-N,N-dimethyl-3-(4-(3-(piperidin-1-yl)propoxy)phenyl)propan-1-amine | Drug Info |
| EGFR3 --- HER2 | {4-(1-Benzyl-1H-indazol-5-ylamino)-5-ethyl-pyrrolo[2,1-f][1,2,4]triazin-6-yl}-carbamic acid,(3S)-3-morpholinylmethyl ester | Drug Info |
| PI3K gamma --- PI3K delta | (3-(6-((4-(Methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinothieno[3,2-d]pyrimidin-2-yl)phenyl)methanol | Drug Info |
| VEGFR2 --- VEGFR1 | 4-(2,4-Dichloro-benzoylsulfamoyl)-benzoic acid methyl ester | Drug Info |
| H3 --- SERT | 3-(4-fluorophenoxy)-N,N-dimethyl-3-(4-(3-(piperidin-1-yl)propoxy)phenyl)propan-1-amine | Drug Info |
| EGFR3 --- HER2 | 7-(4-(3-Ethynyl-4-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide | Drug Info |
| PI3K gamma --- PI3K delta | 2-(6-(1H-pyrazol-4-yl)-2H-benzo[b][1,4]oxazin-4(3H)-yl)-6,6-dimethyl-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| VEGFR2 --- VEGFR1 | 1-methyl-4-(pyridin-3-ylmethylamino)-N-(4-(trifluoromethyl)phenyl)-1H-imidazole-5-carboxamide | Drug Info |
| H3 --- SERT | 4-(4-chloro-3-fluorophenyl)-2-methyl-7-(3-(piperidin-1-yl)propoxy)-1,2,3,4-tetrahydro-2,6-naphthyridine | Drug Info |
| EGFR3 --- HER2 | (E)-2-(2-Methyl-5-nitro-1H-imidazol-1-yl)ethyl 3-(naphthalen-1-yl)acrylate | Drug Info |
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