Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| VEGFR2 --- CSrc | N-(4-(7-amino-3-(4-(4-methylpiperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-6-yl)phenyl)-4-(trifluoromethyl)benzamide | Drug Info |
| Ftase --- FPTase | Lithium; (S)-2-{[2'-methyl-5-(5-phenyl-furan-2-ylmethoxymethyl)-biphenyl-2-carbonyl]-amino}-4-methylsulfanyl-butyrate | Drug Info |
| mTOR --- PI3K gamma | 1-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl)-3-(4-cyanophenyl)urea | Drug Info |
| VEGFR2 --- EGFR3 | (2E)-4-(dimethylamino)-N-(4-{[3,6-dioxo-4-(2-thienylmethoxy)cyclohexa-1,4-dien-1-yl]amino}-7-ethoxyquinazolin-6-yl)but-2-enamide | Drug Info |
| Ftase --- FPTase | (S)-2-[2-({(S)-3-Methyl-2-[2-(2-nitro-benzylsulfanyl)-acetylamino]-pentyl}-naphthalen-1-ylmethyl-amino)-acetylamino]-4-methylsulfanyl-butyric acid | Drug Info |
| mTOR --- PI3K gamma | N-(2-(Dimethylamino)ethyl)-4-(3-(4-(4,6-dimorpholino-1,3,5-triazin-2-yl)phenyl)ureido)-N-methylbenzamide Hydrochloride | Drug Info |
| VEGFR2 --- FGFR1 | N2-(3,5-dimorpholinophenyl)-N4-(3-methoxyphenyl)-N4-methylpyrimidine-2,4-diamine | Drug Info |
| Ftase --- FPTase | 6-(3-Chloro-phenyl)-8-[(4-chloro-phenyl)-hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]-2,3-dihydro-1-oxa-3a-aza-phenalen-4-one | Drug Info |
| mTOR --- PI3K gamma | 1-[4-(3-Ethyl-7-morpholin-4-yl-3H-[1,2,3]triazolo-[4,5-d]pyrimidin-5-yl)phenyl]-3-pyridin-3-ylurea | Drug Info |
| VEGFR2 --- TEK | N-(5-(4-((2-fluoro-5-(trifluoromethyl)phenyl)aminocarbonylamino)phenoxy)-1H-benzimidazol-2-yl)-2-(4-methylpiperazin-1-yl)acetamide | Drug Info |
| Ftase --- FPTase | 3-benzo[1,3]dioxol-5-yl-4-[(4-cyano-phenyl)-(2,3-dimethyl-3H-imidazol-4-yl)-methoxymethyl]-benzonitrile | Drug Info |
| NET --- SERT | CHEMBL1199321 | Drug Info |
| VEGFR2 --- TEK | 1-(3-methyl-4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea | Drug Info |
| Ftase --- FPTase | Lithium; (S)-2-{[2'-methyl-5-(5-pyridin-4-yl-furan-2-ylmethoxymethyl)-biphenyl-2-carbonyl]-amino}-4-methylsulfanyl-butyrate | Drug Info |
| NET --- SERT | 3N-{3-[4-(4-chlorophenyl)-1-methyl-(3R,4S)-hexahydro-3-pyridinylcarboxamido]propyl}-4-(4-chlorophenyl)-1-methyl-(3R,4S)-hexahydro-3-pyridinecarboxamide | Drug Info |
| VEGFR2 --- TEK | methyl N-(5-(4-((3-(trifluoromethyl)phenyl)aminocarbonylamino)phenoxy)-1H-benzimidazol-2-yl)carbamate | Drug Info |
| Ftase --- FPTase | N-(2,4-difluorobenzyl)-N-((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methyl)quinoline-2-carboxamide | Drug Info |
| NPKCdelta --- NPKCtheta | 3-methyl-4-(4-methyl-1H-indol-5-ylamino)-2-(3-oxo-3-(pyrrolidin-1-yl)prop-1-enyl)thieno[2,3-b]pyridine-5-carbonitrile | Drug Info |
| VEGFR2 --- TEK | N-(3-methyl-4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)phenyl)-6-(trifluoromethyl)-1H-benzo[d]imidazol-2-amine | Drug Info |
| Ftase --- FPTase | 4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1-carboxylic acid methyl-pyridin-3-yl-amide | Drug Info |
| NPKCdelta --- NPKCtheta | 3-(5-cyano-4-(4-methyl-1H-indol-5-ylamino)thieno[2,3-b]pyridin-2-yl)-N-(pyrrolidin-1-yl)acrylamide | Drug Info |
| VEGFR2 --- TEK | 1-(3-methyl-4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)phenyl)-3-phenylurea | Drug Info |
| Ftase --- FPTase | (S)-2-{[6-((R)-2-Amino-3-mercapto-propionylamino)-naphthalene-1-carbonyl]-amino}-4-methylsulfanyl-butyric acid | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(4-methyl-1H-indol-5-yloxy)-5-styrylnicotinonitrile | Drug Info |
| VEGFR2 --- TEK | 9-butyl-6-methyl-12-(tetrahydro-2H-pyran-2-yl)-6,7,8,9-tetrahydro-1H-indazolo[5,4-a]pyrrolo[3,4-c]carbazol-3(2H)-one | Drug Info |
| Ftase --- FPTase | 5-((E)-4,8-Dimethyl-nona-3,7-dienyl)-3a,4,7,7a-tetrahydro-isobenzofuran-1,3-dione | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(4-methyl-1H-indol-5-ylamino)-2-(3-oxo-3-(pyrrolidin-1-yl)propyl)thieno[2,3-b]pyridine-5-carbonitrile | Drug Info |
| VEGFR2 --- VEGFR1 | [4-(2-Phenyl-imidazol-1-yl)-pyrimidin-2-yl]-m-tolyl-amine | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(4-methyl-1H-indol-5-ylamino)-2-(3-(pyrrolidine-1-carbonyl)phenyl)thieno[2,3-b]pyridine-5-carbonitrile | Drug Info |
| VEGFR2 --- VEGFR1 | 4-(pyridin-4-ylmethylamino)-N-(4-(trifluoromethoxy)phenyl)isothiazole-3-carboxamide | Drug Info |
| Ftase --- FPTase | (S)-2-[3-({(4-Cyano-benzyl)-[3-(4-cyano-benzyl)-3H-imidazol-4-ylmethyl]-amino}-methyl)-benzoylamino]-4-methylsulfanyl-butyric acid methyl ester | Drug Info |
| CAII --- CAI | 2-Amino-N-(2-fluoro-4-sulfamoyl-phenyl)-acetamide | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(4-methyl-1H-indol-5-ylamino)-5-(5-(piperazin-1-ylmethyl)benzofuran-2-yl)nicotinonitrile | Drug Info |
| VEGFR2 --- VEGFR1 | N-(4-isopropylphenyl)-5-(1-methyl-4-(pyridin-4-ylmethylamino)-1H-imidazol-5-yl)-1,3,4-oxadiazol-2-amine | Drug Info |
| H3 --- SERT | N,N-dimethyl-3-(4-nitrophenoxy)-3-(4-(3-(piperidin-1-yl)propoxy)phenyl)propan-1-amine | Drug Info |
| EGFR3 --- HER2 | N-(4-(3-chloro-4-fluorophenylamino)-3-cyano-7-(trifluoromethoxy)quinolin-6-yl)-4-(dimethylamino)but-2-enamide | Drug Info |
| NPKCdelta --- NPKCtheta | 3-(5-cyano-4-(4-methyl-1H-indol-5-ylamino)thieno[2,3-b]pyridin-2-yl)-N-(2-(dimethylamino)ethyl)-N-methylacrylamide | Drug Info |
| VEGFR2 --- VEGFR1 | 2-((5H-imidazo[4,5-c]pyridin-5-yl)methyl)-N-(4-chlorophenyl)benzamide | Drug Info |
| H3 --- SERT | 1-(4-ethylphenyl)-3-methyl-6-(4-(4-(1-phenylvinyl)cyclohexyl)butyl)-1,2,3,4-tetrahydronaphthalene | Drug Info |
| EGFR3 --- HER2 | 1-(5-Bromo-2-hydroxybenzyl)-1-(4-hydroxybenzyl)-3-phenylurea | Drug Info |
| PI3K gamma --- PI3K delta | 1-(2-methyl-3-(trifluoromethyl)benzyl)-7-morpholinoimidazo[1,2-a]pyrimidin-5(1H)-one | Drug Info |
| VEGFR2 --- VEGFR1 | N-(4-Chloro-phenyl)-N'-pyridin-4-ylmethyl-phthalazine-1,4-diamine | Drug Info |
| H3 --- SERT | 4-(4-methoxyphenyl)-2-methyl-7-(3-(piperidin-1-yl)propoxy)-1,2,3,4-tetrahydroisoquinoline | Drug Info |
| EGFR3 --- HER2 | 4-Dimethylamino-but-2-enoic acid [4-(1-benzenesulfonyl-1H-indol-5-ylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-amide | Drug Info |
| PI3K gamma --- PI3K delta | 6,6-dimethyl-2-(6-(6-(4-methylpiperazin-1-yl)pyridazin-3-yl)-2H-benzo[b][1,4]oxazin-4(3H)-yl)-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| VEGFR2 --- VEGFR1 | N-(2,4-Dichloro-benzoyl)-3-nitro-benzenesulfonamide | Drug Info |
| H3 --- SERT | (5-bromo-2-(4-(methylthio)phenoxy)phenyl)-N-methylmethanamine | Drug Info |
| EGFR3 --- HER2 | 4-Dimethylamino-but-2-enoic acid [4-(4-benzylamino-3-chloro-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-amide | Drug Info |
| PI3K gamma --- PI3K delta | 6,6-dimethyl-2-(6-(6-methylpyridin-3-yl)-2,3-dihydrobenzo[b][1,4]oxazin-4-yl)-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| VEGFR2 --- VEGFR1 | Dimethyl-{2-methyl-3-[3-(5-thiophen-3-yl-pyridin-3-yl)-indol-1-yl]-propyl}-amine | Drug Info |
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