Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| BNOS --- Hepatocyte NOS | 4-((2-(Cyclopropylmethyl)-1H-benzo[d]imidazol-1-yl)methyl)-7,8-difluoroquinolin-2(1H)-one | Drug Info |
| BNOS --- Hepatocyte NOS | N-(3-Aminomethyl-phenyl)-acetamidine | Drug Info |
| BNOS --- Hepatocyte NOS | AR-C133057XX | Drug Info |
| CAI --- CAIX | 2H-Pyran-2-thione | Drug Info |
| 5HT1a --- SERT | (S)-1-(2-Methyl-1H-indol-4-yloxy)-3-[(2S,4R)-2-methyl-4-(4-methyl-benzo[b]thiophen-2-yl)-piperidin-1-yl]-propan-2-ol | Drug Info |
| 5HT1a --- SERT | (S)-1-((2S,4R)-4-(5-fluorobenzo[b]thiophen-2-yl)-2-methylpiperidin-1-yl)-3-(2-methyl-1H-indol-4-yloxy)propan-2-ol | Drug Info |
| 5HT1a --- SERT | (S)-1-(1H-indol-4-yloxy)-3-(4-(4-methoxybenzo[b]thiophen-2-yl)piperidin-1-yl)propan-2-ol | Drug Info |
| 5HT1b --- SERT | 3-(3,4-Dimethoxy-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester | Drug Info |
| 5LOX --- HRH1 | N-hydroxycarbamate derivative | Drug Info |
| ADRA1A --- HRH1 | OLANZAPINE_N-OXIDE METABOLITE | Drug Info |
| ADRA1A --- HRH1 | Trazodone | Drug Info |
| ADRA1A --- HRH1 | PROCHLORPERAZINE | Drug Info |
| CABL --- CD135 | PHA-739358 | Drug Info |
| CABL --- FGFR1 | Sorafenib | Drug Info |
| CAI --- CAIX | 4-Benzythiopyridine-3-sulfonamide | Drug Info |
| Aurora --- VEGFR | 7-(5-hydroxy-1H-indol-2-yl)isoindolin-1-one | Drug Info |
| AuroraA --- STK1 | N-(4-(3-(2-(Methylamino)pyrimidin-4-yl)pyridin-2-yloxy)phenyl)-4-phenylphthalazin-1-amine | Drug Info |
| AuroraA --- STK1 | CHEMBL518981 | Drug Info |
| AuroraA --- STK1 | (2S,5R)-4-[6-(3-Amino-1H-indazol-6-yl)-2-(methylamino)-4-pyrimidinyl]-5-ethyl-N-phenyl-2-morpholinecarboxamide | Drug Info |
| AuroraA --- STK1 | 3-(1-((2S,6R)-2,6-dimethylmorpholino)cyclopropyl)-N-(6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl)isothiazol-5-amine | Drug Info |
| AuroraA --- STK1 | N-(4-(4-(azetidin-1-yl)-6-(5-methyl-1H-pyrazol-3-ylamino)pyrimidin-2-ylthio)phenyl)propionamide | Drug Info |
| AuroraA --- STK1 | 1,1-Dimethylethyl{(3R,6S)-1-[2-Amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-6-methyl-3-piperidinyl}carbamate | Drug Info |
| AuroraA --- STK1 | N-{4-[1-Ethyl-4-(2-{[(2-hydroxyethyl)amino]methyl}-1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-3-yl]phenyl}-N'-phenylurea | Drug Info |
| AuroraA --- STK1 | N'-[4-(1-Ethyl-4-{2-[4-(1-pyrrolidinylmethyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-1H-pyrazol-3-yl)phenyl]-N,N-dimethylurea | Drug Info |
| B1R --- B2R | [Hyp3, Thi5, D-NMF7] Bradykinin | Drug Info |
| Beta PDGFR --- CABL | 2-methoxy-N-(4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)benzamide | Drug Info |
| BNOS --- Hepatocyte NOS | Azonan-(2Z)-ylideneamine | Drug Info |
| BNOS --- Hepatocyte NOS | 7-Allyl-azepan-(2Z)-ylideneamine; hydrochloride | Drug Info |
| BNOS --- Hepatocyte NOS | 2-Amino-3-[2-(N'-methyl-guanidino)-phenyl]-propionic acid | Drug Info |
| BNOS --- Hepatocyte NOS | CHEMBL174310 | Drug Info |
| BNOS --- Hepatocyte NOS | N-(2-(4-amino-5,8-difluoro-1,2-dihydroquinazolin-2-yl)ethyl)furan-3-carboxamide | Drug Info |
| BNOS --- Hepatocyte NOS | 4-bromo-2-((methyl(1-methylpiperidin-4-yl)amino)methyl)benzonitrile | Drug Info |
| BNOS --- Hepatocyte NOS | 2-Ethyl-1-(4-methoxy-phenyl)-isothiourea; hydriodide | Drug Info |
| BNOS --- Hepatocyte NOS | (4R,5R)-4-Ethyl-5-methyl-selenazolidin-(2Z)-ylideneamine | Drug Info |
| BNOS --- Hepatocyte NOS | (3aR,9bS)-7-(2-Methylamino-ethoxy)-2,3,3a,9b-tetrahydro-1H-cyclopenta[c]quinolin-4-ylamine | Drug Info |
| BNOS --- Hepatocyte NOS | N-(4-Dimethylaminomethyl-phenyl)-acetamidine | Drug Info |
| 5HT1a --- SERT | 6-{1-[2-(2-Methyl-quinolin-5-yloxy)-ethyl]-piperidin-4-ylmethyl}-4H-benzo[1,4]oxazin-3-one | Drug Info |
| 5HT1a --- SERT | 2-((4-(1H-indol-3-yl)-5,6-dihydropyridin-1(2H)-yl)methyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine | Drug Info |
| 5HT1a --- SERT | (S)-1-[(1R,3S,5S)-3-(4-Methoxy-benzo[b]thiophen-2-yl)-8-aza-bicyclo[3.2.1]oct-8-yl]-3-(2-methyl-1H-indol-4-yloxy)-propan-2-ol | Drug Info |
| 5HT1b --- SERT | 2'-Methyl-4'-(5-methyl-[1,2,4]oxadiazol-3-yl)-biphenyl-4-carboxylic acid [4-(2-fluoro-ethoxy)-3-(4-methyl-piperazin-1-yl)-phenyl]-amide | Drug Info |
| A3AR --- ADRA1A | 4-(2-Oxo-2,3-dihydro-benzoimidazol-1-yl)-piperidine-1-carboxylic acid 6-chloro-benzo[1,3]dioxol-5-ylmethyl ester | Drug Info |
| ADRA1A --- HRH1 | (5,11-Difluoro-2,3,3a,8-tetrahydro-1-oxa-12b-aza-dibenzo[e,h]azulen-2-ylmethyl)-dimethyl-amine | Drug Info |
| ADRA1A --- HRH1 | Amoxapine | Drug Info |
| ADRA1A --- HRH1 | 4-[(3-Chlorophenyl)methyl]-2-{[(2R)-1-methyl-2-pyrrolidinyl]methyl}-1(2H)-phthalazinone | Drug Info |
| CABL --- Ckit | (5-hydroxy-1H-indol-2-yl)(1H-indol-2-yl)methanone | Drug Info |
| CABL --- STK1 | PHA848125 | Drug Info |
| Aurora --- GSK | 2-(2,4-dichlorophenylthio)-N-(5-methyl-1H-pyrazol-3-yl)quinazolin-4-amine | Drug Info |
| AuroraA --- ALK5 | 6-(3-Amino-1H-indazol-6-yl)-N4-(1-methylethyl)-2,4-pyrimidinediamine | Drug Info |
| AuroraA --- STK1 | 4-[3-(4-N-Phenylcarbamylaminophenyl)-1-ethyl-1H-pyrazol-4-yl]-2-[3-(dimethylaminomethyl)phenyl]-1H-pyrrolo[2,3-b]pyridine | Drug Info |
| AuroraA --- STK1 | (4-[3-(4-N-Ethylcarbamylaminophenyl)-1-ethyl-1H-pyrazol-4-yl]-2-[4-(N-morpholinylmethyl)phenyl]-1H-pyrrolo[2,3-b]pyridine | Drug Info |
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