Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| 5HT1a --- SERT | (S)-1-[(2S,4R)-4-(4,6-Dimethyl-benzo[b]thiophen-2-yl)-2-methyl-piperidin-1-yl]-3-(2-methyl-1H-indol-4-yloxy)-propan-2-ol | Drug Info |
| 5HT1b --- SERT | (2-(3,4-dichlorobenzyl)phenyl)-N,N-dimethylmethanamine | Drug Info |
| AChE --- NMDA | 1-Methyl-9-[9-(1-methyl-beta-carboline-9-yl)nonyl]-beta-carboline | Drug Info |
| ADRA1A --- HRH1 | Amitriptyline | Drug Info |
| ADRA1A --- HRH1 | CHEMBL1620822 | Drug Info |
| ADRA1A --- HRH1 | Pipamazine | Drug Info |
| CABL --- DNPK1 | PP121 | Drug Info |
| CABL --- VEGFR1 | AAL-993 | Drug Info |
| Aurora --- GSK | 1-Methyl-8-{[1-(methylsulfonyl)piperidin-4-yl]amino}-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide | Drug Info |
| AuroraA --- CDK4 | 7-3-methoxyphenyl-N-4-4-methylpiperazin-1-yl-phenyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine | Drug Info |
| AuroraA --- STK1 | N-Phenyl-N'-{4-[4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1-(tetrahydro-2-furanylmethyl)-1H-pyrazol-3-yl]phenyl}urea | Drug Info |
| AuroraA --- STK1 | N-(3-fluorophenyl)-2-(2-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinazolin-4-yl]amino}-1,3-thiazol-5-yl)acetamide | Drug Info |
| AuroraA --- STK1 | N-2,3-difluorophenyl-2-3-7-3-4-hydroxypiperidin-1-yl-propoxy-6-methoxyquinazolin-4-ylamino-1H-pyrazol-5-yl-acetamide | Drug Info |
| AuroraA --- STK1 | 8-(3-methylisothiazol-5-ylamino)-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazine-6-carbonitrile | Drug Info |
| AuroraA --- STK1 | N-(4-(1H-benzo[d]imidazol-2-ylamino)phenethyl)thieno[3,2-d]pyrimidin-4-amine | Drug Info |
| AuroraA --- STK1 | BARASERTIB | Drug Info |
| AuroraA --- STK1 | N-[3-[(3-Fluoro-1-piperidinyl)methyl]-5-isothiazolyl]-6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-amine Hydrochloride | Drug Info |
| AuroraA --- STK1 | 2,9-Dihydro-3-methylpyrazolo[4,3:4,5]cyclopenta[1,2-b]indole | Drug Info |
| CDK1 --- Cyclin E | compound 18 | Drug Info |
| BNOS --- Hepatocyte NOS | Azonan-(2Z)-ylideneamine | Drug Info |
| BNOS --- Hepatocyte NOS | 7-Allyl-azepan-(2Z)-ylideneamine; hydrochloride | Drug Info |
| BNOS --- Hepatocyte NOS | 2-Amino-3-[2-(N'-methyl-guanidino)-phenyl]-propionic acid | Drug Info |
| BNOS --- Hepatocyte NOS | CHEMBL174310 | Drug Info |
| BNOS --- Hepatocyte NOS | N-(2-(4-amino-5,8-difluoro-1,2-dihydroquinazolin-2-yl)ethyl)furan-3-carboxamide | Drug Info |
| BNOS --- Hepatocyte NOS | 4-bromo-2-((methyl(1-methylpiperidin-4-yl)amino)methyl)benzonitrile | Drug Info |
| BNOS --- Hepatocyte NOS | 2-Ethyl-1-(4-methoxy-phenyl)-isothiourea; hydriodide | Drug Info |
| BNOS --- Hepatocyte NOS | (4R,5R)-4-Ethyl-5-methyl-selenazolidin-(2Z)-ylideneamine | Drug Info |
| BNOS --- Hepatocyte NOS | (3aR,9bS)-7-(2-Methylamino-ethoxy)-2,3,3a,9b-tetrahydro-1H-cyclopenta[c]quinolin-4-ylamine | Drug Info |
| BNOS --- Hepatocyte NOS | N-(4-Dimethylaminomethyl-phenyl)-acetamidine | Drug Info |
| 5HT1a --- SERT | (S)-1-(2-Methyl-1H-indol-4-yloxy)-3-[(2S,4R)-2-methyl-4-(4-methyl-benzo[b]thiophen-2-yl)-piperidin-1-yl]-propan-2-ol | Drug Info |
| 5HT1a --- SERT | (S)-1-((2S,4R)-4-(5-fluorobenzo[b]thiophen-2-yl)-2-methylpiperidin-1-yl)-3-(2-methyl-1H-indol-4-yloxy)propan-2-ol | Drug Info |
| 5HT1a --- SERT | (S)-1-(1H-indol-4-yloxy)-3-(4-(4-methoxybenzo[b]thiophen-2-yl)piperidin-1-yl)propan-2-ol | Drug Info |
| 5HT1b --- SERT | 3-(3,4-Dimethoxy-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester | Drug Info |
| 5LOX --- HRH1 | N-hydroxycarbamate derivative | Drug Info |
| ADRA1A --- HRH1 | OLANZAPINE_N-OXIDE METABOLITE | Drug Info |
| ADRA1A --- HRH1 | Trazodone | Drug Info |
| ADRA1A --- HRH1 | PROCHLORPERAZINE | Drug Info |
| CABL --- CD135 | PHA-739358 | Drug Info |
| CABL --- FGFR1 | Sorafenib | Drug Info |
| CAI --- CAIX | 4-Benzythiopyridine-3-sulfonamide | Drug Info |
| Aurora --- VEGFR | 7-(5-hydroxy-1H-indol-2-yl)isoindolin-1-one | Drug Info |
| AuroraA --- STK1 | N-(4-(3-(2-(Methylamino)pyrimidin-4-yl)pyridin-2-yloxy)phenyl)-4-phenylphthalazin-1-amine | Drug Info |
| AuroraA --- STK1 | CHEMBL518981 | Drug Info |
| AuroraA --- STK1 | (2S,5R)-4-[6-(3-Amino-1H-indazol-6-yl)-2-(methylamino)-4-pyrimidinyl]-5-ethyl-N-phenyl-2-morpholinecarboxamide | Drug Info |
| AuroraA --- STK1 | 3-(1-((2S,6R)-2,6-dimethylmorpholino)cyclopropyl)-N-(6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl)isothiazol-5-amine | Drug Info |
| AuroraA --- STK1 | N-(4-(4-(azetidin-1-yl)-6-(5-methyl-1H-pyrazol-3-ylamino)pyrimidin-2-ylthio)phenyl)propionamide | Drug Info |
| AuroraA --- STK1 | 1,1-Dimethylethyl{(3R,6S)-1-[2-Amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-6-methyl-3-piperidinyl}carbamate | Drug Info |
| AuroraA --- STK1 | N-{4-[1-Ethyl-4-(2-{[(2-hydroxyethyl)amino]methyl}-1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-3-yl]phenyl}-N'-phenylurea | Drug Info |
| AuroraA --- STK1 | N'-[4-(1-Ethyl-4-{2-[4-(1-pyrrolidinylmethyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-1H-pyrazol-3-yl)phenyl]-N,N-dimethylurea | Drug Info |
| B1R --- B2R | [Hyp3, Thi5, D-NMF7] Bradykinin | Drug Info |
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