Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| BNOS --- Hepatocyte NOS | 4-chloro-2-((methyl(piperidin-3-yl)amino)methyl)benzonitrile | Drug Info |
| BNOS --- Hepatocyte NOS | (R)-3-Propyl-[1,4]thiazepan-(5E)-ylideneamine | Drug Info |
| BNOS --- Hepatocyte NOS | SID11111337 | Drug Info |
| BNOS --- Hepatocyte NOS | (3aS,9bR)-8-Chloro-3a-fluoro-2,3,3a,9b-tetrahydro-1H-cyclopenta[c]quinolin-4-ylamine | Drug Info |
| BNOS --- Hepatocyte NOS | 5-Pentyl-4-trifluoromethyl-pyrrolidin-(2E)-ylideneamine; hydrochloride | Drug Info |
| BNOS --- Hepatocyte NOS | 4,4-Dimethyl-piperidin-(2Z)-ylideneamine | Drug Info |
| BNOS --- Hepatocyte NOS | (3aS,9bR)-7-[3-(3-Chloro-benzylamino)-propyl]-3a-fluoro-2,3,3a,9b-tetrahydro-1H-cyclopenta[c]quinolin-4-ylamine | Drug Info |
| BNOS --- Hepatocyte NOS | 3-Butyl-[1,4]thiazepan-(5E)-ylideneamine | Drug Info |
| BNOS --- Hepatocyte NOS | 2-Ethyl-1-p-tolyl-isothiourea; hydrochloride | Drug Info |
| BNOS --- Hepatocyte NOS | N-(3-Chlorophenyl)-N-((8-fluoro-2-oxo-1,2-dihydroquinolin-4-yl)methyl)-3-methylpicolinamide | Drug Info |
| 5HT1a --- SERT | 2-{1-[(S)-2-Hydroxy-3-(1H-indol-4-yloxy)-propyl]-piperidin-4-yl}-benzo[b]thiophen-6-ol | Drug Info |
| 5HT1a --- SERT | 6-{1-[2-(3a,7a-Dihydro-1H-indol-4-yloxy)-ethyl]-piperidin-4-yloxy}-4H-benzo[1,4]oxazin-3-one | Drug Info |
| 5HT1a --- SERT | 3-(4-(2-methoxyphenyl)piperazin-1-yl)-1-(4-nitrophenyl)propan-1-ol | Drug Info |
| 5HT1b --- SERT | SID396188 | Drug Info |
| AChE --- NMDA | CHEMBL1198977 | Drug Info |
| ADRA1A --- HRH1 | 4-chloro-N-((cis)-4-(4-(dimethylamino)-6-methylpyrimidin-2-ylamino)cyclohexyl)benzamide | Drug Info |
| ADRA1A --- HRH1 | 4-[(4-Chlorophenyl)methyl]-2-{1-[(4-{[3-(hexahydro-1H-azepin-1-yl)propyl]oxy}phenyl)methyl]hexahydro-1H-azepin-4-yl}-1(2H)-phthalazinone | Drug Info |
| ADRA1A --- HRH1 | 11-(piperazin-1-yl)-5H-benzo[e]imidazo[1,2-a]azepine | Drug Info |
| CABL --- Ckit | Dasatinib | Drug Info |
| CABL --- TEK | NVP-TAE684 | Drug Info |
| Aurora --- GSK | 2-(4-(5-nitro-4-(phenylamino)pyrimidin-2-ylamino)phenoxy)acetic acid | Drug Info |
| AuroraA --- CD135 | N3-(2-chlorophenyl)-1-(pyridin-2-yl)-1H-1,2,4-triazole-3,5-diamine | Drug Info |
| AuroraA --- STK1 | N2-(4-(benzo[d]thiazol-2-yl)phenyl)-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine | Drug Info |
| AuroraA --- STK1 | N-(4-(4-(4-tert-butylpiperazin-1-yl)-6-(5-methyl-1H-pyrazol-3-ylamino)pyrimidin-2-ylthio)phenyl)propionamide | Drug Info |
| AuroraA --- STK1 | N-(6-methyl-3-(phenylethynyl)-1H-indazol-5-yl)-2-(thiophen-2-yl)acetamide | Drug Info |
| AuroraA --- STK1 | N-(4-(6-chloro-3H-imidazo[4,5-b]pyridin-2-ylamino)phenethyl)thieno[3,2-d]pyrimidin-4-amine | Drug Info |
| AuroraA --- STK1 | N-(6-(2-aminoethyl)-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl)-3-methylisothiazol-5-amine | Drug Info |
| AuroraA --- STK1 | N-Phenyl-N'-{4-[4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-3-yl]phenyl}urea | Drug Info |
| AuroraA --- STK1 | 6-methoxy-N-(5-methyl-1,3-thiazol-2-yl)-7-(3-morpholin-4-ylpropoxy)quinazolin-4-amine | Drug Info |
| AuroraA --- STK1 | 4-[3-(4-N-Phenylcarbamylaminophenyl)-1-ethyl-1H-pyrazol-4-yl]-2-[3-(N-morpholinylmethyl)phenyl]-1H-pyrrolo[2,3-b]pyridine | Drug Info |
| CDK1 --- Cyclin E | AZD-5438 | Drug Info |
| Beta PDGFR --- Ckit | 4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-carboxylic acid (4-cyano-phenyl)-amide | Drug Info |
| BNOS --- Hepatocyte NOS | N1-(3-(1H-imidazol-1-yl)-1,2,4-thiadiazol-5-yl)-N3-(benzo[d][1,3]dioxol-5-ylmethyl)-N1-(furan-2-ylmethyl)propane-1,3-diamine | Drug Info |
| BNOS --- Hepatocyte NOS | 4-chloro-2-((methyl(pyrrolidin-3-yl)amino)methyl)benzonitrile | Drug Info |
| BNOS --- Hepatocyte NOS | 4-(((4-chlorobenzyl)(pyrazin-2-yl)amino)methyl)-7,8-difluoroquinolin-2(1H)-one | Drug Info |
| BNOS --- Hepatocyte NOS | 1-(2-Chloro-phenyl)-2-ethyl-isothiourea; hydrochloride | Drug Info |
| BNOS --- Hepatocyte NOS | ethyl 2-((3-(1H-imidazol-1-yl)-1,2,4-thiadiazol-5-yl)(3-(benzo[d][1,3]dioxol-5-ylmethylamino)propyl)amino)acetate | Drug Info |
| BNOS --- Hepatocyte NOS | 4-chloro-2-(((cyclopropylmethyl)(piperidin-4-yl)amino)methyl)benzonitrile | Drug Info |
| BNOS --- Hepatocyte NOS | N-{2-[1-(4-methoxy-benzyl)-piperidin-4-ylamino]-benzothiazol-6-yl}-thiophene-2-carboxamidine | Drug Info |
| BNOS --- Hepatocyte NOS | 4-ethyl-pyrrolidin-2-ylideneamine | Drug Info |
| BNOS --- Hepatocyte NOS | N-(3-Aminomethyl-phenyl)-2-methylsulfanyl-acetamidine | Drug Info |
| CAI --- CAIX | 5,6-dihydro-2H-pyran-2-one | Drug Info |
| 5HT1a --- SERT | 1-phenyl-3-(4-(pyridin-2-yl)piperazin-1-yl)propan-1-one | Drug Info |
| 5HT1a --- SERT | (S)-1-(1H-Indol-4-yloxy)-3-[(4S,6R)-2-methyl-4-(4-trifluoromethyl-benzo[b]thiophen-2-yl)-piperidin-1-yl]-propan-2-ol | Drug Info |
| 5HT1a --- SERT | 3-(4-(4-nitrophenyl)piperazin-1-yl)-1-phenylpropan-1-ol | Drug Info |
| 5HT1a --- SERT | 3-(4-(4-chlorophenyl)piperazin-1-yl)-1-phenylpropan-1-one | Drug Info |
| 5LOX --- HRH1 | [3-(5-{4-[(R)-(4-Chloro-phenyl)-phenyl-methyl]-piperazin-1-ylmethyl}-furan-2-yl)-1-methyl-prop-2-ynyl]-N-hydroxyurea | Drug Info |
| ADRA1A --- HRH1 | 4-[(4-Fluorophenyl)methyl]-2-{[(2R)-1-methyl-2-pyrrolidinyl]methyl}-1(2H)-phthalazinone | Drug Info |
| ADRA1A --- HRH1 | SID56463056 | Drug Info |
| ADRA1A --- HRH1 | 4-[(4-Chlorophenyl)methyl]-2-{1-[2-(4-{[3-(hexahydro-1H-azepin-1-yl)propyl]oxy}phenyl)ethyl]hexahydro-1H-azepin-4-yl}-1(2H)-phthalazinone | Drug Info |
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