Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| ADRA1A --- HRH1 | 2-Ethyl-10-piperazin-1-yl-4H-3-thia-4,9-diaza-benzo[f]azulene | Drug Info |
| CABL --- FGFR1 | PHA-739358 | Drug Info |
| CAI --- CAIX | 4-Amino-3-iodo-benzenesulfonamide | Drug Info |
| Aurora --- VEGFR | N-(1-hydroxy-2,2,6,6-tetramethylpiperidin-4-yl)-3-(7-(3-hydroxyphenylamino)pyrazolo[1,5-a]pyrimidin-2-yl)benzamide | Drug Info |
| AuroraA --- STK1 | CHEMBL381721 | Drug Info |
| AuroraA --- STK1 | (S)-(4-((5-(6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-ylamino)isothiazol-3-yl)methyl)morpholin-3-yl)methanol | Drug Info |
| AuroraA --- STK1 | 1,1-Dimethylethyl{(3R,5R)-1-[2-amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-5-methyl-3-piperidinyl}carbamate | Drug Info |
| AuroraA --- STK1 | N-(4-(4-(4-ethylpiperazin-1-yl)-6-(5-methyl-1H-pyrazol-3-ylamino)pyrimidin-2-ylthio)phenyl)propionamide | Drug Info |
| AuroraA --- STK1 | CHEMBL215495 | Drug Info |
| AuroraA --- STK1 | 2-(2,5-dimethoxyphenyl)-N-(6-methyl-3-styryl-1H-indazol-5-yl)acetamide | Drug Info |
| AuroraA --- STK1 | 2-(5-Methyl-1H-pyrazol-3-yl)-1H-indole | Drug Info |
| AuroraA --- STK1 | 2-(5-(2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl)thiazol-2-yl)-N-(3-(trifluoromethyl)phenyl)acetamide | Drug Info |
| B-Raf --- MEK | 3-benzyl-4-methyl-2-oxo-2H-chromen-7-yl cyclopropanecarboxylate | Drug Info |
| Beta PDGFR --- CABL | N-(4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl)piperidine-1-carboxamide | Drug Info |
| Beta PDGFR --- FGFR1 | (Z)-4-(4-((2-oxoindolin-3-ylidene)methyl)phenyl)piperazine-1-carbaldehyde | Drug Info |
| BNOS --- Hepatocyte NOS | 5-(4-(4-methoxypyridin-2-ylamino)piperidine-1-carbonyl)picolinonitrile | Drug Info |
| BNOS --- Hepatocyte NOS | (4'-amino-5'-fluoro-1'H-spiro[piperidine-4,2'-quinazoline]-1-yl)(4-(aminomethyl)phenyl)methanone | Drug Info |
| BNOS --- Hepatocyte NOS | 7-(3,4-dimethoxyphenyl)-6-methylquinazoline-2,4-diamine | Drug Info |
| BNOS --- Hepatocyte NOS | 6-[4-(1-Aza-bicyclo[2.2.2]oct-2-ylmethoxy)-naphthalen-1-yl]-pyridin-2-ylamine | Drug Info |
| BNOS --- Hepatocyte NOS | 4-((2-(Cyclobutylmethyl)-1H-benzo[d]imidazol-1-yl)methyl)-7,8-difluoroquinolin-2(1H)-one | Drug Info |
| BNOS --- Hepatocyte NOS | 4-(((3-chlorophenyl)(6-(dimethylamino)pyrimidin-4-yl)amino)methyl)-7,8-difluoroquinolin-2(1H)-one | Drug Info |
| BNOS --- Hepatocyte NOS | 4-((2-Cyclobutyl-1H-imidazo[4,5-b]pyrazin-1-yl)methyl)-8-fluoroquinolin-2(1H)-one | Drug Info |
| BNOS --- Hepatocyte NOS | 5-Chloro-3-morpholin-4-ylmethyl-3H-benzooxazol-2-one | Drug Info |
| BNOS --- Hepatocyte NOS | (3aR,9bS)-6-Fluoro-2,3,3a,9b-tetrahydro-1H-cyclopenta[c]quinolin-4-ylamine | Drug Info |
| CAI --- CAIX | 1-(4'-Aminophenyl)-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-sulfonamide | Drug Info |
| 5HT1a --- SERT | [3-(5-Fluoro-1H-indol-3-yl)-propyl]-[2-(quinoxalin-5-yloxy)-ethyl]-amine | Drug Info |
| 5HT1a --- SERT | 1-(biphenyl-4-yl)-3-(4-(2-methoxyphenyl)piperazin-1-yl)propan-1-one | Drug Info |
| 5HT1a --- SERT | 3-(4-(4-fluorophenyl)piperazin-1-yl)-1-phenylpropan-1-one | Drug Info |
| 5HT1b --- SERT | (3-(2-Fluoroethoxy)-2-methoxyphenyl)-(1-(2-p-toluylphenylethyl)-piperidine-4-yl)-methanol | Drug Info |
| 5LOX --- HRH1 | N-hydroxycarbamate derivative | Drug Info |
| ADRA1A --- HRH1 | Dimethyl-(11-methyl-2,3,3a,8-tetrahydro-1-oxa-12b-aza-dibenzo[e,h]azulen-2-ylmethyl)-amine | Drug Info |
| ADRA1A --- HRH1 | Revospirone | Drug Info |
| ADRA1A --- HRH1 | (9-Fluoro-2,3,3a,8-tetrahydro-1-oxa-12b-aza-dibenzo[e,h]azulen-2-ylmethyl)-dimethyl-amine | Drug Info |
| CABL --- CD135 | CUDC-101 | Drug Info |
| CABL --- MCSF | MCL-1-specific antisense oligonucleotide + nilotinib (AMN107) | Drug Info |
| CAI --- CAIX | 1-valproylamido-5-sulfonamidoindane | Drug Info |
| Aurora --- VEGFR | 4-(2-(3-(6-methoxy-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)vinyl)isoquinoline | Drug Info |
| AuroraA --- STK1 | 2,5,6,8,12-Pentahydro-3,10,10-trimethyl-9-oxopyrazolo[4,3:6,7]cyclohepta[1,2-b]pyrrolo[2,3-f]indole | Drug Info |
| AuroraA --- STK1 | 4-[3-(4-N,N-Dimethylcarbamylaminophenyl)-1-ethyl-1H-pyrazol-4-yl]-2-[3-(N-pyrrolidinylmethyl)phenyl]-1H-pyrrolo[2,3-b]-pyridine | Drug Info |
| AuroraA --- STK1 | 2-3-7-3-4-hydroxymethyl-piperidin-1-yl-propoxy-6-methoxyquinazolin-4-ylamino-1H-pyrazol-5-yl-N-3-trifluoromethyl-phenyl-acetamide | Drug Info |
| AuroraA --- STK1 | N-(4-fluorophenyl)-2-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinazolin-4-yl]amino}-1,3-thiazole-5-carboxamide | Drug Info |
| AuroraA --- STK1 | N-(4-(4-(4-cyclopropylpiperazin-1-yl)-6-(5-methyl-1H-pyrazol-3-ylamino)pyrimidin-2-ylthio)phenyl)propionamide | Drug Info |
| AuroraA --- STK1 | 4-methyl-1-((5-(6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-ylamino)isothiazol-3-yl)methyl)piperazin-2-one | Drug Info |
| AuroraA --- STK1 | N-(6-(pyrrolidin-1-yl)-3-styryl-1H-indazol-5-yl)-2-(thiophen-2-yl)acetamide | Drug Info |
| AuroraA --- STK1 | 6-Methyl-3-(1H-pyrazol-4-yl)-N-[3-[[4-(trifluoromethyl)-1-piperidinyl]methyl]-5-isothiazolyl]imidazo[1,2-a]pyrazin-8-amine Hydrochloride | Drug Info |
| B1R --- B2R | D-Arg-[L-NMF7] Bradykinin | Drug Info |
| Beta PDGFR --- CD135 | (6-Chloro-1H-indol-2-yl)-(5-methoxy-1H-indol-2-yl)-methanone | Drug Info |
| BNOS --- Hepatocyte NOS | 2-Ethyl-1-(2-methoxy-phenyl)-isothiourea; hydrochloride | Drug Info |
| BNOS --- Hepatocyte NOS | N-(5-chloro-2-(trifluoromethyl)benzyl)-N,1-dimethylpiperidin-4-amine | Drug Info |
| BNOS --- Hepatocyte NOS | (3aR,9bS)-7-[3-(3-Chloro-benzylamino)-propyl]-2,3,3a,9b-tetrahydro-1H-cyclopenta[c]quinolin-4-ylamine | Drug Info |
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