Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| BNOS --- Hepatocyte NOS | N-(4-Morpholin-4-ylmethyl-phenyl)-acetamidine | Drug Info |
| BNOS --- Hepatocyte NOS | 7-Propyl-azepan-(2Z)-ylideneamine; hydrochloride | Drug Info |
| BNOS --- Hepatocyte NOS | N-(4-(2-(3-chlorophenethylamino)ethyl)phenyl)thiophene-2-carboximidamide | Drug Info |
| BNOS --- Hepatocyte NOS | 4-((2-Cyclobutyl-7-(dimethylamino)-3H-imidazo[4,5-b]pyridin-3-yl)methyl)-7,8-difluoroquinolin-2(1H)-one | Drug Info |
| BNOS --- Hepatocyte NOS | N-(1-(Piperidin-4-yl)indolin-6-yl)thiophene-2-carboximidamide | Drug Info |
| BNOS --- Hepatocyte NOS | 6-[4-(2-Pyrrolidin-1-yl-ethoxy)-5,6,7,8-tetrahydro-naphthalen-1-yl]-pyridin-2-ylamine | Drug Info |
| BNOS --- Hepatocyte NOS | SID124879390 | Drug Info |
| 5HT1a --- SERT | 1-phenyl-3-(4-(pyridin-2-yl)piperazin-1-yl)propan-1-ol | Drug Info |
| 5HT1a --- SERT | 6-{4-[2-(Quinolin-5-yloxy)-ethyl]-piperazin-1-ylmethyl}-4H-benzo[1,4]oxazin-3-one | Drug Info |
| 5HT1a --- SERT | [2-(Benzofuran-7-yloxy)-ethyl]-[3-(5-fluoro-1H-indol-3-yl)-propyl]-amine | Drug Info |
| 5HT1b --- SERT | SID124881379 | Drug Info |
| AChE --- NMDA | CHEMBL1198988 | Drug Info |
| ADRA1A --- HRH1 | CHEMBL2079357 | Drug Info |
| ADRA1A --- HRH1 | Dimethyl-[2-(2,3,3a,8-tetrahydro-1-oxa-12b-aza-dibenzo[e,h]azulen-2-yl)-ethyl]-amine | Drug Info |
| ADRA1A --- HRH1 | CHEMBL1623195 | Drug Info |
| CABL --- Ckit | MCL-1-specific antisense oligonucleotide + nilotinib (AMN107) | Drug Info |
| CABL --- TEK | compound 8h | Drug Info |
| Aurora --- GSK | N-1-Dimethyl-8-{[1-(phenylcarbonyl)piperidin-4-yl]amino}-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide | Drug Info |
| AuroraA --- CD221 | K00603a | Drug Info |
| AuroraA --- STK1 | 4-methyl-N-(3-(2-(6-methyl-5-(2-(thiophen-2-yl)acetamido)-1H-indazol-3-yl)vinyl)phenyl)piperazine-1-carboxamide | Drug Info |
| AuroraA --- STK1 | 4-[3-(4-N-Ethylcarbamylaminophenyl)-1-ethyl-1H-pyrazol-4-yl]-2-[4-(dimethylaminomethyl)phenyl]-1H-pyrrolo[2,3-b]pyridine | Drug Info |
| AuroraA --- STK1 | N-(4-(4-methyl-6-(5-methyl-1H-pyrazol-3-ylamino)pyrimidin-2-ylthio)phenyl)acetamide | Drug Info |
| AuroraA --- STK1 | (Z)-N-[2-Oxo-3-({4-oxo-3-[3-oxo-3-(pyrrolidin-1-yl)propyl]-4,5,6,7-tetrahydro-1H-indol-2-yl}methylene)indolin-5-yl]benzenesulfonamide | Drug Info |
| AuroraA --- STK1 | 1-(3,4-dichlorophenyl)-3-(5-(2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl)thiazol-2-yl)urea | Drug Info |
| AuroraA --- STK1 | 4-[3-(4-N-Ethylcarbamylaminophenyl)-1-ethyl-1H-pyrazol-4-yl]-2-[3-(dimethylaminomethyl)phenyl]-1H-pyrrolo[2,3-b]pyridine | Drug Info |
| AuroraA --- STK1 | N-(4-methyl-3-(3-((4-methylpiperazin-1-yl)methyl)styryl)-1H-indazol-5-yl)-2-(thiophen-2-yl)acetamide | Drug Info |
| AuroraA --- STK1 | N-(4-(4-tert-butyl-6-(5-methyl-1H-pyrazol-3-ylamino)pyrimidin-2-ylthio)phenyl)propionamide | Drug Info |
| CDK1 --- Cyclin E | Flavopiridol | Drug Info |
| Beta PDGFR --- Ckit | 4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-carbothioic acid benzylamide | Drug Info |
| BNOS --- Hepatocyte NOS | 6-[8-(2-Dimethylamino-ethoxy)-1,2,3,4-tetrahydro-1,4-methano-naphthalen-5-yl]-pyridin-2-ylamine | Drug Info |
| BNOS --- Hepatocyte NOS | 4,6-Dimethyl-piperidin-(2Z)-ylideneamine | Drug Info |
| BNOS --- Hepatocyte NOS | (4R,5S)-5-Ethyl-4-methyl-selenazolidin-(2Z)-ylideneamine | Drug Info |
| BNOS --- Hepatocyte NOS | 6-{4-[2-(4-Methyl-piperazin-1-yl)-ethoxy]-5,6,7,8-tetrahydro-naphthalen-1-yl}-pyridin-2-ylamine | Drug Info |
| BNOS --- Hepatocyte NOS | 2-Ethyl-1-(2-isopropyl-phenyl)-isothiourea; hydrochloride | Drug Info |
| BNOS --- Hepatocyte NOS | 1-(4-Benzyloxy-phenyl)-2-ethyl-isothiourea; hydriodide | Drug Info |
| BNOS --- Hepatocyte NOS | Azepan-(2Z)-ylideneamine; hydrochloride | Drug Info |
| BNOS --- Hepatocyte NOS | 4-(((3-chlorophenyl)(pyrimidin-2-yl)amino)methyl)-7,8-difluoroquinolin-2(1H)-one | Drug Info |
| BNOS --- Hepatocyte NOS | (S)-methyl 2-amino-5-(3-methylguanidino)pentanoate | Drug Info |
| CAI --- CAIX | 4-[4-phenethylamino(thioxo)methylaminophenylsulfonamidomethyl]-1-benzenesulfonamide | Drug Info |
| 5HT1a --- SERT | [2-(1H-Indol-4-yloxy)-ethyl]-[3-(1H-indol-3-yl)-propyl]-amine | Drug Info |
| 5HT1a --- SERT | 3-(1H-indol-3-yl)-N-((4-isopropyl-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)methyl)propan-1-amine | Drug Info |
| 5HT1a --- SERT | (S)-1-((2S,4R)-4-(benzo[b]thiophen-2-yl)-2-methylpiperidin-1-yl)-3-(2-methyl-1H-indol-4-yloxy)propan-2-ol | Drug Info |
| 5HT1a --- SERT | 3-(4-(4-methoxyphenyl)piperazin-1-yl)-1-phenylpropan-1-one | Drug Info |
| 5LOX --- HRH1 | 1-{4-[4-(4-{4-[(R)-(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}butoxy)phenyl]but-3-yn-1-yl}-1-hydroxyurea | Drug Info |
| ADRA1A --- HRH1 | N-[4-(4-Dimethylamino-quinazolin-2-ylamino)-cyclohexyl]-2,3,4-trifluoro-benzamide | Drug Info |
| ADRA1A --- HRH1 | (R)-2-((1-(4-(4-(3-(azepan-1-yl)propoxy)phenyl)butyl)pyrrolidin-2-yl)methyl)-4-(4-chlorobenzyl)phthalazin-1(2H)-one | Drug Info |
| ADRA1A --- HRH1 | 1-(3-chlorophenyl)-3-(piperidin-2-ylmethyl)imidazolidin-2-one | Drug Info |
| ADRA1A --- HRH1 | 2,8-Dimethyl-5-((Z)-styryl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole | Drug Info |
| CABL --- FGFR1 | NVP-TAE684 | Drug Info |
| CAI --- CAIX | Decane-1,10-diyl disulfamate | Drug Info |
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