Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| PPAR gamma --- PPAR delta | 5-chloro-2-(3-(6-methoxy-1H-indol-1-ylsulfonyl)benzamido)benzoic acid | Drug Info |
| HDAC1 --- HDAC2 | N9-(4-(4-methoxyphenyl)thiazol-2-yl)-N1-methyl-2-oxononanediamide | Drug Info |
| EGFR3 --- VEGFR1 | 2-(2-{4-[7-(2-Methyl-1H-indol-5-ylamino)-thieno[3,2-b]pyridin-2-yl]-benzylamino}-ethoxy)-ethanol | Drug Info |
| PPAR gamma --- PPAR delta | 2-(3-(2-carboxy-4-chlorophenylcarbamoyl)phenylsulfonyl)-1,2,3,4-tetrahydroisoquinoline-5-carboxylic acid | Drug Info |
| HDAC1 --- HDAC2 | 4-((4-(1H-pyrazol-5-yl)pyrimidin-2-ylamino)methyl)-N-(2-aminophenyl)benzamide | Drug Info |
| Erbeta --- ER | 1-{3-[4-((S)-2,8-Dihydroxy-11,12-dihydro-5H-6,13-dioxa-benzo[3,4]cyclohepta[1,2-a]naphthalen-5-yl)-phenoxy]-propyl}-pyrrolidine-2,5-dione | Drug Info |
| PPAR gamma --- PPAR delta | 5-methyl-2-(3-(4-methyl-1H-indol-1-ylsulfonyl)benzamido)benzoic acid | Drug Info |
| HDAC1 --- HDAC2 | 4-(3-(4-(2-Chlorobenzyloxy)-3-methoxyphenyl)propanamido)-N-hydroxybenzamide | Drug Info |
| Erbeta --- ER | 4-[2-(4-hydroxyphenyl)-1-(10-pentylsulfonyldecyl)-(E)-1-butenyl]phenol | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-(2-(pent-2-ynyloxy)-4-((4-(trifluoromethyl)phenoxy)methyl)phenylthio)-5,6,7,8-tetrahydronaphthalen-1-yloxy)acetic acid | Drug Info |
| HDAC1 --- HDAC2 | N-hydroxy-7-(4-(4-(trifluoromethyl)phenyl)thiazol-2-yl)heptanamide | Drug Info |
| Erbeta --- ER | 2-(4-Hydroxy-phenyl)-3-[4-(2-piperidin-1-yl-ethoxy)-benzoyl]-benzo[b]thiophene-6-carboxylic acid methyl ester | Drug Info |
| PPAR gamma --- PPAR delta | 2-Ethoxy-3-(4-(5-(4-(trifluoromethyl)phenyl)-4-(4-methoxyphenyl)thiazol-2-yl)methoxyphenyl)propanoic Acid | Drug Info |
| HDAC1 --- HDAC4 | Octanethioic acid S-[(E)-4-((5R,8S,11S)-5-benzyl-8-isopropyl-6,9,13-trioxo-10-oxa-3,17-dithia-7,14,19,20-tetraaza-tricyclo[14.2.1.1*2,5*]icosa-1(18),2(20),16(19)-trien-11-yl)-but-3-enyl]ester | Drug Info |
| HDAC1 --- HDAC4 | cyclo(-L-Am7(S2Py)-Aib-L-Ph5-D-Pro-) | Drug Info |
| Erbeta --- ER | 3-(3-bromo-4-hydroxyphenyl)benzo[d]isoxazol-6-ol | Drug Info |
| PPAR gamma --- PPAR delta | 2-isopropoxy-3-(4-((5-o-tolyl-1,2,4-oxadiazol-3-yl)methoxy)phenyl)propanoic acid | Drug Info |
| HER2 --- CD221 | 3-(2-(2-methoxybenzyl)-1H-benzo[d]imidazol-6-yl)-1-((trans)-4-morpholinocyclohexyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | Drug Info |
| Erbeta --- ER | SID124876662 | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-(2-(3-(2,4-difluorophenyl)-1-heptylureido)ethyl)phenylthio)-2-methylpropanoic acid | Drug Info |
| HER2 --- MMP-2 | (1S,2S,5RS)-N-hydroxy-5-(2-morpholino-2-oxoethyl)-2-(4-phenylpiperazine-1-carbonyl)cyclohexanecarboxamide | Drug Info |
| Erbeta --- ER | 10-allyl-3-hydroxy-4,8-dimethyl-6H-benzo[c]chromen-6-one | Drug Info |
| PPAR gamma --- PPAR delta | 3-{4-[4-Methyl-2-(4-trifluoromethyl-phenyl)-oxazol-5-ylmethoxy]-phenyl}-propionic acid | Drug Info |
| JNK1 --- JNK3 | ethyl 4-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)piperidine-1-carboxylate | Drug Info |
| Erbeta --- ER | 4-Bromo-2-(4-hydroxy-phenyl)-7-methoxy-benzofuran-5-ol | Drug Info |
| PPAR gamma --- PPAR delta | (+/-)-2-{5-[(4-Adamantan-1-yl-2-fluoro-benzoylamino)-methyl]-4-ethoxy-2-fluoro-benzyl}-butyric acid | Drug Info |
| JNK1 --- JNK3 | 5-ethyl-N-(3-methyl-2-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)phenyl)furan-2-carboxamide | Drug Info |
| Erbeta --- ER | 4-((1R,2S,5R)-5-Hydroxymethyl-1,8-dimethyl-3-oxa-bicyclo[3.3.1]non-7-en-2-yl)-phenol | Drug Info |
| PPAR gamma --- PPAR delta | 2-ethoxy-3-(3-methyl-1-((5-methyl-2-(4-(trifluoromethyl)phenyl)oxazol-4-yl)methyl)-1H-indol-5-yl)propanoic acid | Drug Info |
| JNK1 --- JNK3 | N-(4-cyano-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(2-oxo-3,4-dihydro-1,5-naphthyridin-1(2H)-yl)acetamide | Drug Info |
| Erbeta --- ER | (E)-3-[4-(6-Hydroxy-1-phenyl-3,4-dihydro-1H-isoquinolin-2-yl)-phenyl]-N,N-dimethyl-acrylamide | Drug Info |
| PPAR gamma --- PPAR delta | 2-(8-(4-(4-(trifluoromethyl)benzyloxy)benzylthio)chroman-5-yloxy)acetic acid | Drug Info |
| JNK1 --- JNK3 | 4-amino-5-cyano-6-ethoxy-pyridine-2-carboxylic acid 2,5-dimethoxy-benzylamide | Drug Info |
| Erbeta --- ER | 4-[2-(4-hydroxyphenyl)-1-(10-pentylsulfanyldecyl)-(E)-1-butenyl]phenol | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-{2-[2-Butoxy-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)phenyl]ethyl}benzyl)butyric acid | Drug Info |
| JNK1 --- JNK3 | (3S)-N-(4-(2-(4-fluorophenylamino)pyridin-4-yl)pyridin-2-yl)-tetrahydrofuran-3-carboxamide | Drug Info |
| Erbeta --- ER | 3-[1-ethyl-2-(4-hydroxyphenyl)-12-pentylsulfonyl-(E)-1-dodecenyl]phenol | Drug Info |
| PPAR gamma --- PPAR delta | 3-(4-((R)-3-(4-ethyl-2-(thiazol-2-yl)phenoxy)butoxy)-2-methylphenyl)propanoic acid | Drug Info |
| JNK1 --- JNK3 | 4-(8-(2-fluorophenylamino)-2-(4-methoxyphenylamino)-9H-purin-9-yl)cyclohexanecarboxamide | Drug Info |
| Erbeta --- ER | Toluene-4-sulfonic acid 10-((11S,13S,17S)-3,17-dihydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-11-yl)-decyl ester | Drug Info |
| JNK1 --- JNK3 | 1-acetyl-N-(4-(2-(4-fluorophenylamino)pyridin-4-yl)pyridin-2-yl)piperidine-3-carboxamide | Drug Info |
| Erbeta --- ER | 9a-butyl-6-furan-2-yl-8,9,9a,10-tetrahydro-3H-1,2,3-triaza-cyclopenta[a]fluoren-7-one | Drug Info |
| JNK1 --- JNK3 | methyl 4-(2-(naphthalen-1-yl)acetamido)thiophene-3-carboxylate | Drug Info |
| PPAR gamma --- PPAR delta | 5-[2-(2-biphenyl-4-yl-5-methyl-oxazol-4-yl)-ethoxy]-8-(2-carboxy-ethyl)-3,4-dihydro-1H-isoquinoline-2-carboxylic acid propyl ester | Drug Info |
| Erbeta --- ER | {4-[4-(4-Chloro-phenyl)-piperazin-1-yl]-phenyl}-[6-hydroxy-2-(4-hydroxy-phenyl)-benzo[b]thiophen-3-yl]-methanone | Drug Info |
| JNK1 --- JNK3 | N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(2-oxo-6-(trifluoromethoxy)quinolin-1(2H)-yl)acetamide | Drug Info |
| PR --- mRNA of AR | N-(1-Difluoromethoxy-6-phenyl-6H-benzo[c]chromen-8-yl)-methanesulfonamide | Drug Info |
| Erbeta --- ER | (2S,3R)-2-{4-[2-(8-Aza-bicyclo[3.2.1]oct-8-yl)-ethoxy]-phenyl}-3-(4-hydroxy-phenyl)-2,3-dihydro-benzo[1,4]oxathiin-6-ol | Drug Info |
| JNK3 --- MAPK | 6-((S)-3-Isobutyl-piperazin-1-yl)-3-naphthalen-1-yl-4-pyridin-4-yl-pyridazine | Drug Info |
| PR --- mRNA of AR | (5-Allyl-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysen-10-yl)-methanol | Drug Info |
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