Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Ftase --- FPTase | 4-{(S)-1-[(S)-1-((S)-1-Carboxy-2-hydroxy-ethylcarbamoyl)-3-methyl-butylcarbamoyl]-2-methyl-propylcarbamoyl}-2-((2E,6E)-3,7,11-trimethyl-dodeca-2,6,10-trienoylamino)-butyric acid | Drug Info |
| S5AR --- SRD5A2 | (8R,9S,10R,13S,14S)-17-(1H-imidazol-1-yl)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15-decahydro-1H-cyclopenta[a]phenanthren-3(2H)-one | Drug Info |
| MMP2 --- MMP3 | (2S,4R)-2-Butyl-4-[(S)-2,2-dimethyl-1-(pyridin-4-ylcarbamoyl)-propylcarbamoyl]-6-(4'-fluoro-biphenyl-4-yl)-hexanoic acid | Drug Info |
| Ftase --- FPTase | 3-alFPP | Drug Info |
| S5AR --- SRD5A2 | (4aR,6aS)-4a,6a-Dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxylic acid ethyl-phenyl-amide | Drug Info |
| MMP2 --- MMP3 | 2-[4-(2,3'-dimethyl-biphenyl-4-yl)-3,6-dihydro-2H-pyridine-1-sulfonyl]-N-hydroxy-acetamide | Drug Info |
| Ftase --- FPTase | N-(4-bromophenethyl)-N-((4-(4-cyanobenzyl)-4H-1,2,4-triazol-3-yl)methyl)quinoline-2-carboxamide | Drug Info |
| ABL --- Src | 4-(4-Chloro-phenylamino)-6,7-dimethoxy-quinoline-3-carbonitrile | Drug Info |
| MMP2 --- MMP9 | rac-N,2-dihydroxy-2-methyl-3-(N-(4-(p-tolyloxy)phenyl)methan-15-ylsulfonamido)propanamide | Drug Info |
| Ftase --- FPTase | 4-{2-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-oxo-ethyl}-piperidine-1-carboxylic acid tert-butyl ester | Drug Info |
| ABL --- Src | 4-(2-Bromo-4-chloro-5-methoxy-phenylamino)-6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinoline-3-carbonitrile | Drug Info |
| MMP2 --- MMP9 | 2-[7-(3,5-Dichloro-benzyloxy)-1,1-dioxo-1,3,4,5-tetrahydro-1lambda*6*-benzo[f][1,2,5]thiadiazepin-2-yl]-N-hydroxy-propionamide | Drug Info |
| Ftase --- FPTase | 1-((2R,3R)-3-Allyloxy-6-chloro-2,3-dihydro-benzo[b]thiophen-2-ylmethyl)-1H-imidazole | Drug Info |
| FGFR --- Src | 2-Cyclohexylamino-6-(2,6-dichloro-phenyl)-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one | Drug Info |
| MMP2 --- MMP9 | (S)-1-(biphenyl-4-ylsulfonyl)-N-hydroxy-5-oxopyrrolidine-2-carboxamide | Drug Info |
| Ftase --- FPTase | 4-(5-{[3-(2-Methyl-benzyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[d]azepin-1-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile | Drug Info |
| TRIP5 --- mRNA of KIF11 | 2-hydroxyethyl (S)-1-((S)-4-(2,5-difluorophenyl)-2-phenyl-2H-pyrrol-1(5H)-yl)-3,3-dimethyl-1-oxobutan-2-ylcarbamate | Drug Info |
| MMP2 --- MMP9 | (S)-N,2-dihydroxy-3-(N-(4-(2-(4-methoxyphenyl)ethynyl)phenyl)methan-8-ylsulfonamido)propanamide | Drug Info |
| Ftase --- FPTase | (2E,6E)-3-ethyl-7,11-dimethyldodeca-2,6,10-trienyl trihydrogen diphosphate | Drug Info |
| TRIP5 --- mRNA of KIF11 | 2-(3'-Hydroxyphenyl)-3-benzyl-6-(4-methylpiperazin-1-yl)-1,4-dihydroquinoline-4-one | Drug Info |
| MMP2 --- MMP9 | (S)-N-hydroxy-2-((R)-1-phenylethylamino)-3-(N-(4-(p-tolyloxy)phenyl)methan-2-ylsulfonamido)propanamide | Drug Info |
| Ftase --- FPTase | 1-[4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-pyridin-4-yl-ethanone | Drug Info |
| TRIP5 --- mRNA of KIF11 | SID93577497 | Drug Info |
| MMP2 --- MMP9 | 2-(4'-chloro-biphenyl-4-sulfonyl)-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-pentanoic acid | Drug Info |
| Ftase --- FPTase | 2-(3-Benzoyl-phenoxy)-4-imidazol-1-ylmethyl-benzonitrile | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-[3,5-difluoro-4'-(trifluoromethyl)-4-biphenylyl]sulfamide | Drug Info |
| MMP2 --- MMP9 | 4-(4-chlorophenoxy)-N-(1-hydroxy-2-oxo-1,2-dihydropyridin-3-yl)benzenesulfonamide | Drug Info |
| Ftase --- FPTase | N-Isopropyl-2-(2-phenyl-1H-indol-3-yl)-N-pyridin-2-ylmethyl-acetamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | (+/-)-3-amino-1-(6-methyl-1-phenyl-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)propan-1-one | Drug Info |
| MMP2 --- MMP9 | (R)-2-[4-(4-Methyl-benzoylamino)-benzenesulfonylamino]-3-phenyl-propionic acid | Drug Info |
| Ftase --- FPTase | (+)4-{2-[4-(4-chloro-3,6,7,12-tetrahydropyrido[2',3':4,5]cyclohepta[e]indol-12-yl)hexahydro-1-pyridinyl]-2-oxoethyl}-1-pyridiniumolate | Drug Info |
| TRIP5 --- mRNA of KIF11 | (+/-)-2-amino-1-(1-(3-hydroxyphenyl)-6-methyl-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)ethanone | Drug Info |
| MMP2 --- MMP9 | (R)-3-(1H-Indol-3-yl)-2-[4-(4-methoxy-phenylethynyl)-benzenesulfonylamino]-propionic acid | Drug Info |
| Ftase --- FPTase | (S)-2-(2-{Benzyl-[(S)-2-(3-mercapto-propionylamino)-3-methyl-pentyl]-amino}-acetylamino)-4-methylsulfanyl-butyric acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-[3-cyano-4'-(trifluoromethyl)-4-biphenylyl]sulfamide | Drug Info |
| MMP2 --- MMP9 | (R)-N*4*-Hydroxy-N*1*-((1S,2R)-2-hydroxy-indan-1-yl)-2-(3'-methyl-biphenyl-4-ylmethyl)-succinamide | Drug Info |
| Ftase --- FPTase | 4'-{[3-(4-Amino-benzyl)-3H-imidazol-4-ylmethyl]-amino}-[1,1';2',1'']terphenyl-3-carboxylic 28 (FTI-2347) | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(3-amino-3-oxopropyl)-N-((3-benzyl-7-chloro-4-oxo-3,4-dihydropyrrolo[1,2-f][1,2,4]triazin-2-yl)(cyclopropyl)methyl)-4-methylbenzamide | Drug Info |
| MMP2 --- MMP9 | (6S,7S)-5-methanesulfonyl-6-(4-phenyl-3,4-dihydro-2H-pyridine-1-carbonyl)-5-aza-spiro[2.5]octane-7-carboxylic acid hydroxyamide | Drug Info |
| Ftase --- FPTase | Chaetomellic acid B | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(2-aminoethyl)-4-methyl-N-(((2R,4aS,5R,10bS)-5-phenyl-9-(trifluoromethyl)-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-2-yl)methyl)benzamide | Drug Info |
| MMP3 --- MMP8 | 2-(5-Pyridin-2-yl-thiophen-2-ylmethanesulfonyl)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid hydroxyamide | Drug Info |
| Ftase --- FPTase | (S)-4-{1-[1-((S)-1-(S)-Carboxy-2-hydroxy-ethylcarbamoyl)-3-methyl-butylcarbamoyl]-2-methyl-propylcarbamoyl}-2-((2E,6E)-3,7,11-trimethyl-dodeca-2,6,10-trienylcarbamoyl)-butyric acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | 2-(4-methoxyphenylamino)-1-(2-(trifluoromethyl)benzyl)-1H-benzo[d]imidazole-5-carboxamide | Drug Info |
| MMP3 --- MMP8 | 2-(2-Pyridin-4-yl-ethanesulfonyl)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid hydroxyamide | Drug Info |
| Ftase --- FPTase | 6-[Amino-(4-chloro-phenyl)-(4-methyl-4H-[1,2,4]triazol-3-yl)-methyl]-4-(3-chloro-phenyl)-1-methyl-1H-quinolin-2-one | Drug Info |
| TRIP5 --- mRNA of KIF11 | (4aS,10bS)-9-tert-butyl-5-phenyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinoline | Drug Info |
| MMP9 --- MMP14 | N-{(S)-1-[(R)-2-(4-Benzyloxy-phenyl)-1-dimethylcarbamoyl-ethylcarbamoyl]-2-phenyl-ethyl}-N'-hydroxy-oxalamide | Drug Info |
| Ftase --- FPTase | 1-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidin-1-yl]-2-[1-(1-oxy-pyridine-3-carbonyl)-piperidin-4-yl]-ethanone | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-amino-5-[4-(3-hydroxy-phenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxamido]-3-oxa-pentane | Drug Info |
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