Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Cathepsin K --- Cathepsin B | (R)-1-(5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl)-3,3-dimethylbutan-2-yl(S)-1,2-dioxo-1-((R)-1-phenylethylamino)heptan-3-ylcarbamate | Drug Info |
| Cathepsin K --- Cathepsin B | N-Cyanomethyl-3-cyclopropyl-2-[4'-(4-methyl-piperazin-1-yl)-biphenyl-3-yl]-propionamide | Drug Info |
| Cathepsin K --- Cathepsin B | (S)-1-(5,6-dichloro-1H-benzo[d]imidazol-1-yl)-3,3-dimethylbutan-2-yl (S)-2-oxo-1-(pyridine-2-sulfonamido)heptan-3-ylcarbamate | Drug Info |
| Cathepsin K --- Cathepsin B | Acetic acid (2S,3S)-3-[(1-benzyloxycarbonylamino-cyclopentanecarbonyl)-amino]-4-oxo-azetidin-2-yl ester | Drug Info |
| Cathepsin K --- Cathepsin B | [(S)-2-Pyridin-3-yl-1-((5S,6R)-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]hept-6-ylcarbamoyl)-ethyl]-carbamic acid benzyl ester | Drug Info |
| Cathepsin K --- Cathepsin B | [(S)-1-((5S,6S)-7-Oxo-4-oxa-1-aza-bicyclo[3.2.0]hept-6-ylcarbamoyl)-2-phenyl-propyl]-carbamic acid benzyl ester | Drug Info |
| Cathepsin K --- Cathepsin B | [(S)-1-((R)-4,7-Dioxo-4-(S)-oxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]hept-6-ylcarbamoyl)-2-phenyl-ethyl]-carbamic acid benzyl ester | Drug Info |
| Cathepsin K --- Cathepsin B | benzyl(S)-3-methyl-1-((S)-4-methyl-1-((S)-4-methyl-1-oxopentan-2-ylamino)-1-oxopentan-2-ylamino)-1-oxobutan-2-ylcarbamate | Drug Info |
| Cathepsin K --- Cathepsin B | [3-Methyl-1-(3-{4-methyl-2-[(quinoline-7-carbonyl)-amino]-pentanoylamino}-4-oxo-pyrrolidin-1-ylmethyl)-butyl]-carbamic acid benzyl ester | Drug Info |
| Cathepsin K --- Cathepsin B | (R)-N-(1-cyano-cyclopropyl)-3-methanesulfonyl-2-[(S)-2,2,2-trifluoro-1-(4'-fluoro-biphenyl-4-yl)-ethylamino]-propionamide | Drug Info |
| Cathepsin K --- Cathepsin B | (R)-1-(5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl)-3,3-dimethylbutan-2-yl(S)-1,2-dioxo-1-((S)-2-oxopiperidin-3-ylamino)heptan-3-ylcarbamate | Drug Info |
| Cathepsin K --- Cathepsin B | N-(1-((cyanomethyl)carbamoyl)cyclohexyl)-4-(2-morpholinothiazol-4-yl)benzamide | Drug Info |
| Cathepsin K --- Cathepsin B | [(S)-2-Cyclohexyl-1-((5S,6R)-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]hept-6-ylcarbamoyl)-ethyl]-carbamic acid benzyl ester | Drug Info |
| Cathepsin K --- Cathepsin B | N-(1-((cyanomethyl)carbamoyl)cyclohexyl)-4-morpholinobenzamide | Drug Info |
| Cathepsin K --- Cathepsin B | (S)-3,3-dimethyl-1-(3-(4-(trifluoromethyl)phenyl)-1H-pyrazol-1-yl)butan-2-yl (S)-1-(6-fluoropyridin-2-ylamino)-2-oxoheptan-3-ylcarbamate | Drug Info |
| Cathepsin K --- Cathepsin B | [(S)-2-Thiophen-2-yl-1-((5S,6R)-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]hept-6-ylcarbamoyl)-ethyl]-carbamic acid benzyl ester | Drug Info |
| Cathepsin K --- Cathepsin B | (S)-3,3-dimethyl-1-(3-(4-(trifluoromethyl)phenyl)-1H-pyrazol-1-yl)butan-2-yl (S)-2-oxo-1-(pyridine-2-sulfonamido)heptan-3-ylcarbamate | Drug Info |
| Cathepsin K --- Cathepsin B | (S)-1-(5,6-dichloro-1H-benzo[d]imidazol-1-yl)-3,3-dimethylbutan-2-yl (S)-3-oxo-4-(pyridine-2-sulfonamido)butan-2-ylcarbamate | Drug Info |
| Cathepsin K --- Cathepsin B | Z-leu-Val-Agly-Val-OBzl | Drug Info |
| Cathepsin K --- Cathepsin B | (S)-3,3-dimethyl-1-(4-(4-(trifluoromethyl)phenyl)-1H-pyrazol-1-yl)butan-2-yl (S)-2-oxo-1-(pyridine-2-sulfonamido)heptan-3-ylcarbamate | Drug Info |
| Cathepsin K --- Cathepsin B | [(S)-2-Naphthalen-2-yl-1-((5S,6R)-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]hept-6-ylcarbamoyl)-ethyl]-carbamic acid benzyl ester | Drug Info |
| Cathepsin K --- Cathepsin B | N-Cyanomethyl-3-cyclobutyl-2-[4'-(4-methyl-piperazin-1-yl)-biphenyl-3-yl]-propionamide | Drug Info |
| Cathepsin K --- Cathepsin B | (S)-3,3-dimethyl-1-(4-(4-(trifluoromethyl)phenyl)-1H-imidazol-1-yl)butan-2-yl (S)-2-oxo-1-(pyridine-2-sulfonamido)heptan-3-ylcarbamate | Drug Info |
| Cathepsin K --- Cathepsin B | (S)-3,3-dimethyl-1-(4-(4-(trifluoromethyl)phenyl)-1H-pyrazol-1-yl)butan-2-yl(S)-1-(1H-pyrazol-5-ylamino)-1,2-dioxoheptan-3-ylcarbamate | Drug Info |
| Cathepsin K --- Cathepsin B | (R)-2-((S)-1-(4-bromophenyl)-2,2,2-trifluoroethylamino)-N-(1-cyanocyclopropyl)-3-(methylsulfinyl)propanamide | Drug Info |
| Cathepsin K --- Cathepsin B | (R)-3,3-dimethyl-1-(5-(4-(trifluoromethyl)phenyl)-1,3,4-oxadiazol-2-yl)butan-2-yl(S)-1,2-dioxo-1-(2-oxooxazolidin-3-ylamino)heptan-3-ylcarbamate | Drug Info |
| Cathepsin K --- Cathepsin B | (R)-N-(1-cyanocyclopropyl)-3-(methylsulfinyl)-2-((S)-2,2,2-trifluoro-1-(4-fluorophenyl)ethylamino)propanamide | Drug Info |
| Cathepsin K --- Cathepsin B | (S)-3,3-dimethyl-1-(3-(pyridin-4-yl)-1H-pyrazol-1-yl)butan-2-yl (S)-2-oxo-1-(pyridine-2-sulfonamido)heptan-3-ylcarbamate | Drug Info |
| Cathepsin K --- Cathepsin B | (S)-3,3-dimethyl-1-(3-(4-(trifluoromethyl)phenyl)-1H-pyrazol-1-yl)butan-2-yl (S)-3-oxo-4-(pyridine-2-sulfonamido)butan-2-ylcarbamate | Drug Info |
| Cathepsin K --- Cathepsin B | (S)-2-amino-N-((S,E)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl)pentanamide | Drug Info |
| Cathepsin K --- Cathepsin B | tert-butyl 1-(((S)-1-(5-(furan-2-yl)-1,3,4-oxadiazol-2-yl)-1-oxopentan-2-yl)carbamoyl)cyclohexylcarbamate | Drug Info |
| Cathepsin K --- Cathepsin B | Benzofuran-2-carboxylic acid {3-methyl-1-[2-oxo-3-(pyridine-2-sulfonylamino)-propylcarbamoyl]-butyl}-amide | Drug Info |
| Cathepsin K --- Cathepsin B | N-[(3R)-1-cyano-3-pyrrolidinyl]-4-fluorobenzamide | Drug Info |
| Cathepsin K --- Cathepsin B | 4-(3-(piperidin-1-yl)propyl)-6-(3-(trifluoromethyl)phenyl)pyrimidine-2-carbonitrile | Drug Info |
| Cathepsin K --- Cathepsin B | [(S)-2-(3-Fluoro-phenyl)-1-((5S,6R)-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]hept-6-ylcarbamoyl)-ethyl]-carbamic acid benzyl ester | Drug Info |
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