Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Ftase --- FPTase | 4-(5-{[1-(2-Methylsulfanyl-pyridine-3-carbonyl)-pyrrolidin-3-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile | Drug Info |
| Ftase --- FPTase | 4-(5-{[1-(5-Bromo-pyridine-3-carbonyl)-pyrrolidin-3-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile | Drug Info |
| Ftase --- FPTase | (S)-2-(2-[2-(4-Fluoro-phenyl)-ethyl]-5-{[(1S,4S)-4-(pyridine-3-carbonylsulfanyl)-pyrrolidin-2-ylmethyl]-amino}-benzoylamino)-4-methylsulfanyl-butyric acid isopropyl ester | Drug Info |
| Ftase --- FPTase | (3S)-1-((2R,5R,10S,13R,14R,17R)-17-((2R)-5,6-dihydroxy-6-methylheptan-2-yl)-4,4,10,13,14-pentamethyl-3-oxo-2,3,4,5,6,7,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-2-yl) 5-methyl 3-hydroxy-3-methylpentanedioate | Drug Info |
| Ftase --- FPTase | 4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-(3,3-dimethyl-butyryl)-piperazine-2-carboxylic acid (pyridin-3-ylmethyl)-amide | Drug Info |
| Ftase --- FPTase | N-[6-Cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-N-phenethyl-benzenesulfonamide | Drug Info |
| Ftase --- FPTase | 2-(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidin-1-yl]-2-oxo-ethyl}-piperidin-1-yl)-N,N-diethyl-acetamide | Drug Info |
| Ftase --- FPTase | (S)-1-(3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidine-2-carboxylic acid (pyridin-3-ylmethyl)-amide | Drug Info |
| Ftase --- FPTase | 4-[4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidine-1-carbonyl]-benzoic acid | Drug Info |
| Ftase --- FPTase | N-Methyl-2-phosphonomethyl-N-((2E,6E)-3,7,11-trimethyl-dodeca-2,6,10-trienyl)-malonamic acid | Drug Info |
| Ftase --- FPTase | 4-(5-{[3-(3-Chloro-phenyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[d]azepin-1-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile | Drug Info |
| Ftase --- FPTase | (S)-2-{(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propionylamino)-3-methyl-butyrylamino]-3-phenyl-thiopropionylamino}-4-methylsulfanyl-butyric acid | Drug Info |
| Ftase --- FPTase | [(S)-4-((R)-2-Amino-3-mercapto-propyl)-3-butyl-piperazin-1-yl]-(2,3-dimethyl-phenyl)-methanone | Drug Info |
| Ftase --- FPTase | 1-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidin-1-yl]-2-(1-oxy-pyridin-3-yl)-ethanone | Drug Info |
| Ftase --- FPTase | 2-(3-Acetyl-phenoxy)-4-imidazol-1-ylmethyl-benzonitrile | Drug Info |
| Ftase --- FPTase | N-Isopropyl-2-(2-phenyl-1-propyl-1H-indol-3-yl)-N-pyridin-4-ylmethyl-acetamide | Drug Info |
| Ftase --- FPTase | (S)-2-(3-{[(4-Cyano-benzyl)-(3H-imidazol-4-ylmethyl)-amino]-methyl}-benzoylamino)-4-methylsulfanyl-butyric acid methyl ester | Drug Info |
| Ftase --- FPTase | (S)-2-{[5-(2-Isoquinolin-4-yl-vinyl)-2'-methyl-biphenyl-2-carbonyl]-amino}-4-methylsulfanyl-butyric acid | Drug Info |
| Ftase --- FPTase | 2-({6-[(2-Mercapto-ethylamino)-methyl]-4-naphthalen-1-yl-pyridin-2-ylmethyl}-amino)-ethanethiol | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-5,11-dihydro-10-thia-4-aza-dibenzo[a,d]cyclohepten-5-yl)-piperazin-1-yl]-2-pyridin-4-yl-ethanone | Drug Info |
| Ftase --- FPTase | 4-Benzenesulfonyl-3-benzyl-1-(3H-imidazol-4-ylmethyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-7-carbonitrile | Drug Info |
| Ftase --- FPTase | [1-{[1-(1,3-benzodioxole-5-ylmethyl)-1H-imidazole-5-yl]methyl}-4-(1-naphthyl)-1H-pyrrole-3yl](4-methyl-1-piperazinyl)methanone | Drug Info |
| Ftase --- FPTase | 3-(3-(1H-imidazol-1-yl)propyl)-1-(3-phenoxybenzyl)-5-methyl-5-(naphthalen-1-yl)imidazolidine-2,4-dione | Drug Info |
| Ftase --- FPTase | (R)-5-[4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-5-oxo-pentanoic acid phenylamide | Drug Info |
| Ftase --- FPTase | 2-[3-(3-Ethyl-1-methyl-2-oxo-azepan-3-yl)-phenoxy]-4-(3H-imidazol-4-ylmethyl)-benzonitrile | Drug Info |
| Ftase --- FPTase | {1-[3-(1H-Imidazol-2-yl)-propyl]-1,2,3,5-tetrahydro-benzo[e][1,4]diazepin-4-yl}-naphthalen-1-yl-methanone | Drug Info |
| Ftase --- FPTase | 4-Imidazol-1-ylmethyl-2-(4-methoxy-phenoxy)-benzonitrile | Drug Info |
| Ftase --- FPTase | (S)-2-[(S)-2-((S)-2-{2-[Hydroxy-((2E,6E)-3,7,11-trimethyl-dodeca-2,6,10-trienyl)-phosphinoyloxy]-acetylamino}-3-methyl-butyrylamino)-3-methyl-butyrylamino]-4-methylsulfanyl-butyric acid | Drug Info |
| Ftase --- FPTase | 2-Benzylamino-1-[4-(8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-ethanone | Drug Info |
| Ftase --- FPTase | 4'-{[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-amino}-[1,1';2',1'']terphenyl-3-carboxylic acid methyl ester 25 (FTI-2297) | Drug Info |
| Ftase --- FPTase | 4-[(4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-3-(3,5-difluoro-benzylamino)-benzonitrile | Drug Info |
| Ftase --- FPTase | 4-(5-{[2-(3-Chloro-phenyl)-3-oxo-2,3,4,5-tetrahydro-1H-benzo[c]azepin-4-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile | Drug Info |
| Ftase --- FPTase | (S)-2-({(S)-2-[(S)-2-(2-3H-Imidazol-4-yl-acetylamino)-3-methyl-butyryl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-4-methylsulfanyl-butyric acid | Drug Info |
| Ftase --- FPTase | [1-(3H-Imidazol-4-ylmethyl)-7-pyridin-4-yl-1,2,3,5-tetrahydro-benzo[e][1,4]diazepin-4-yl]-(2-trifluoromethoxy-phenyl)-methanone | Drug Info |
| Ftase --- FPTase | (S)-2-({5-[2-(3H-Imidazol-4-yl)-ethyl]-2'-methyl-biphenyl-2-carbonyl}-amino)-4-methylsulfanyl-butyric acid | Drug Info |
| Ftase --- FPTase | (S)-6-(amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl)-4-(3-chlorophenyl)-1-methylquinolin-2(1H)-one | Drug Info |
| Ftase --- FPTase | (S)-2-({2'-Methyl-5-[2-((E)-6-phenoxy-pyridin-3-yl)-vinyl]-biphenyl-2-carbonyl}-amino)-4-methylsulfanyl-butyric acid | Drug Info |
| Ftase --- FPTase | 4-((5-((1-(2-chlorophenyl)-2-oxopyrrolidin-3-ylamino)methyl)-1H-imidazol-1-yl)methyl)benzonitrile | Drug Info |
| Ftase --- FPTase | 4-{5-[(S)-2-Butyl-4-(2,3-dimethyl-phenyl)-6-oxo-piperazin-1-ylmethyl]-imidazol-1-ylmethyl}-benzonitrile | Drug Info |
| Ftase --- FPTase | 4-Imidazol-1-ylmethyl-2-(3-phenoxy-phenoxy)-benzonitrile | Drug Info |
| Ftase --- FPTase | 3-(3-(1H-imidazol-1-yl)propyl)-5-methyl-5-(naphthalen-1-yl)imidazolidine-2,4-dione | Drug Info |
| Ftase --- FPTase | Sodium salt of (1,1-Difluoro-4,8,12-trimethyl-2-oxo-trideca-3,7,11-trienyl)-phosphonic acid | Drug Info |
| Ftase --- FPTase | 4-(3-Chloro-phenyl)-6-[(4-chloro-phenyl)-(3-methyl-3H-imidazol-4-yl)-methyl]-1-methyl-1H-quinolin-2-one | Drug Info |
| Ftase --- FPTase | 4-Acetyl-3-benzyl-1-(3H-imidazol-4-ylmethyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-7-carbonitrile | Drug Info |
| Ftase --- FPTase | 2-{[1-(Benzyl-thiazol-5-ylmethyl-carbamoyl)-5-o-tolyl-1,2,3,6-tetrahydro-pyridine-4-carbonyl]-amino}-4-methylsulfanyl-butyric acid | Drug Info |
| Ftase --- FPTase | [4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-imidazol-1-yl-methanone | Drug Info |
| Ftase --- FPTase | 1-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidin-1-yl]-2-[1-(1-oxy-pyridine-4-carbonyl)-piperidin-4-yl]-ethanone | Drug Info |
| Ftase --- FPTase | [(S)-2-[4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-1-(4-methoxy-benzylsulfanylmethyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester | Drug Info |
| Ftase --- FPTase | (S)-2-((S)-2-{[(S)-2-((R)-2-Amino-3-mercapto-propylamino)-3-methyl-pentyl]-methyl-amino}-pentanoylamino)-4-hydroxy-butyric acid | Drug Info |
| Ftase --- FPTase | 4-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-piperazine-1-carboxylic acid 2-chloro-benzyl ester | Drug Info |
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