Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Ftase --- FPTase | 1-[4-((R)-3-Bromo-10-methoxy-8-methyl-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidin-1-yl]-2-(1-oxy-pyridin-4-yl)-ethanone | Drug Info |
| Ftase --- FPTase | (S)-2-[(5-{2-[(E)-4-(3,5-Difluoro-benzyloxy)-pyridin-3-yl]-vinyl}-2'-methyl-biphenyl-2-carbonyl)-amino]-4-methylsulfanyl-butyric acid | Drug Info |
| Ftase --- FPTase | 4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-pentanoyl-piperazine-2-carboxylic acid [2-(1H-imidazol-4-yl)-ethyl]-amide | Drug Info |
| Ftase --- FPTase | 4-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-piperazine-1-carboxylic acid 2-methanesulfonyl-benzyl ester | Drug Info |
| Ftase --- FPTase | 4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-(6-oxo-heptanoyl)-piperazine-2-carboxylic acid (pyridin-3-ylmethyl)-amide | Drug Info |
| Ftase --- FPTase | 4-{2-[4-(8-Chloro-11H-10-thia-4-aza-dibenzo[a,d]cyclohepten-5-ylidene)-piperidin-1-yl]-2-oxo-ethyl}-piperidine-1-carboxylic acid amide | Drug Info |
| Ftase --- FPTase | 3-substituted farnesyl diphosphate analogue | Drug Info |
| Ftase --- FPTase | 4'-[(3H-Imidazol-4-ylmethyl)-amino]-[1,1';2',1'']terphenyl-3-carboxylic acid 22 (FTI-2195) | Drug Info |
| Ftase --- FPTase | 4-(3,3-dimethylbutyl)-23-oxo-8-oxa-1,15,17,21-tetraazapentacyclo[19.2.2.13,7.19,13.015,19]heptacosa-3(27),4,6,9(26),10,12,16,18-octaen-10-yl cyanide | Drug Info |
| Ftase --- FPTase | 4-((5-((2-oxo-1-(pyridin-4-yl)pyrrolidin-3-ylamino)methyl)-1H-imidazol-1-yl)methyl)benzonitrile | Drug Info |
| Ftase --- FPTase | 5-{4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-2-[(pyridin-3-ylmethyl)-carbamoyl]-piperazin-1-yl}-5-oxo-pentanoic acid | Drug Info |
| Ftase --- FPTase | (SR)-4-[1-Amino-1-(3-methyl-3H-imidazol-4-yl)-ethyl]-2-[3-(3-ethyl-1-methyl-2-oxo-azepan-3-yl)-phenoxy]-benzonitrile | Drug Info |
| Ftase --- FPTase | (S)-2-[(R)-5-((R)-2-Amino-3-mercapto-propionylamino)-2-(4-methyl-benzyl)-pentanoylamino]-4-methylsulfanyl-butyric acid | Drug Info |
| Ftase --- FPTase | (S)-2-{[5-(2-Imidazol-1-yl-vinyl)-2'-methyl-biphenyl-2-carbonyl]-amino}-4-methylsulfanyl-butyric acid | Drug Info |
| Ftase --- FPTase | 4-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-3-phenylethynyl-benzonitrile | Drug Info |
| Ftase --- FPTase | 4-[(4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-3-(2,2-difluoro-benzo[1,3]dioxol-5-yl)-benzonitrile | Drug Info |
| Ftase --- FPTase | 5-((3-(3-(1H-imidazol-1-yl)propyl)-5-methyl-5-(naphthalen-1-yl)-2,4-dioxoimidazolidin-1-yl)methyl)-2-(methylthio)benzonitrile | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-3-fluoro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-2-pyridin-3-yl-ethanone | Drug Info |
| Ftase --- FPTase | 4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1-carboxylic acid (1-oxy-pyridin-4-yl)-amide | Drug Info |
| Ftase --- FPTase | (S)-3-Phosphono-2-((2E,6E)-3,7,11-trimethyl-dodeca-2,6,10-trienoylamino)-propionic acid | Drug Info |
| Ftase --- FPTase | H-Cys-4-Abz-Met-OH | Drug Info |
| Ftase --- FPTase | 4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1,2-dicarboxylic acid 1-cyclohexylamide 2-[(3-imidazol-1-yl-propyl)-amide] | Drug Info |
| Ftase --- FPTase | N-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-N-(5-cyano-3''-ethoxy-biphenyl-2-ylmethyl)-acetamide | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidin-1-yl]-2-pyridin-4-yl-ethanone | Drug Info |
| Ftase --- FPTase | 4-(3-bromo-8-chloro-6,11-dihydro-5-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1,2-dicarboxylic acid 1-cyclohexylamide 2-[(3-imidazol-1-yl-propyl)-amide] 1-(isobutyl-amide) 2-[(pyridin-3-ylmethyl)-amide] | Drug Info |
| Ftase --- FPTase | [(S)-4-[3-(3H-Imidazol-4-yl)-propyl]-3-(2-methoxy-ethyl)-piperazin-1-yl]-naphthalen-1-yl-methanone | Drug Info |
| Ftase --- FPTase | (S)-2-({5-[(1-Biphenyl-4-ylmethyl-1H-imidazol-4-ylmethyl)-amino]-biphenyl-2-carbonyl}-amino)-4-methylsulfanyl-butyric acid | Drug Info |
| Ftase --- FPTase | (R)-[8-chloro-6-(1-piperazinyl)-1H-benzo[5,6]]cyclohepta[1,2-b]pyridine-11-yl]-1-(methylsulfonyl)piperidine | Drug Info |
| Ftase --- FPTase | [(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidin-1-yl]-2-oxo-ethyl}-piperidine-1-carbonyl)-amino]-acetic acid | Drug Info |
| Ftase --- FPTase | 4-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-3-oct-1-ynyl-benzonitrile | Drug Info |
| Ftase --- FPTase | C-(4-Chloro-phenyl)-C-[5-(3-chloro-phenyl)-imidazo[1,2-a]quinazolin-7-yl]-C-(3-methyl-3H-imidazol-4-yl)-methylamine | Drug Info |
| Ftase --- FPTase | (S)-2-[((S)-2-{(S)-2-[(3H-Imidazol-4-ylmethyl)-amino]-3-methyl-butyryl}-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl)-amino]-4-methylsulfanyl-butyric acid | Drug Info |
| Ftase --- FPTase | 7-Bromo-1-(3H-imidazol-4-ylmethyl)-4-methanesulfonyl-3-(4-methoxy-benzyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine | Drug Info |
| Ftase --- FPTase | 4-(5-{[2-(3-Bromo-phenyl)-3-oxo-2,3,4,5-tetrahydro-1H-benzo[c]azepin-4-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile | Drug Info |
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1-carboxylic acid 1-oxy-pyridin-3-yl ester | Drug Info |
| Ftase --- FPTase | (E)-3-Methoxycarbonyl-2-(16-sulfooxy-hexadecyl)-pent-2-enedioic acid dimethyl ester | Drug Info |
| Ftase --- FPTase | (S)-2-{(R)-2-[3-((R)-2-Amino-3-mercapto-propionylamino)-phenyl]-3-phenyl-propionylamino}-4-methylsulfanyl-butyric acid | Drug Info |
| Ftase --- FPTase | Pyridine-3-sulfonic acid benzyl-[6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-amide | Drug Info |
| Ftase --- FPTase | 6-[(3-Bromo-4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-5-(3-chloro-phenyl)-1-methyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile | Drug Info |
| Ftase --- FPTase | 4-((5-(((3-aminopropyl)(1-benzyl-2-oxopyrrolidin-3-yl)amino)methyl)-1H-imidazol-1-yl)methyl)benzonitrile | Drug Info |
| Ftase --- FPTase | 3-benzo[1,3]dioxol-5-yl-4-[(4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-benzonitrile | Drug Info |
| Ftase --- FPTase | 4-(5-{[2-(3-Fluoro-phenyl)-3-oxo-2,3,4,5-tetrahydro-1H-benzo[c]azepin-4-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile | Drug Info |
| Ftase --- FPTase | 2-(4-{2-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidin-1-yl]-2-oxo-ethyl}-piperidin-1-yl)-acetamide | Drug Info |
| Ftase --- FPTase | (R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propylamino)-3-methyl-butyryl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-succinamic acid | Drug Info |
| Ftase --- FPTase | 5-[3-(4-Cyano-phenyl)-1-hydroxy-1-(3-methyl-3H-imidazol-4-yl)-prop-2-ynyl]-2'-methyl-biphenyl-2-carbonitrile | Drug Info |
| Ftase --- FPTase | 2-(4-Chloro-phenoxy)-4-{5-[4-(3-chloro-phenyl)-3-oxo-piperazin-1-ylmethyl]-imidazol-1-ylmethyl}-benzonitrile | Drug Info |
| Ftase --- FPTase | pentapotassium ({[(3E,7E)-4,8,12-trimethyl-1-phosphonatotrideca-3,7,11-trien-1-yl]phosphinato}methyl)phosphonate | Drug Info |
| Ftase --- FPTase | (S)-2-{3-[((R)-2-Amino-3-mercapto-propionylamino)-methyl]-benzoylamino}-4-methylsulfanyl-butyric acid | Drug Info |
| Ftase --- FPTase | 2-alpha,24,25-trihydroxylanostan-3-one | Drug Info |
| Ftase --- FPTase | (2S)-methyl 2-(2-(3-(2-(1H-imidazol-5-yl)ethyl)-5-methyl-5-(naphthalen-1-yl)-2,4-dioxoimidazolidin-1-yl)acetamido)-4-(methylthio)butanoate | Drug Info |
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