Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Ftase --- FPTase | N-(2,4-difluorobenzyl)-N-((4-(4-cyanobenzyl)-5-methyl-4H-1,2,4-triazol-3-yl)methyl)quinoline-2-carboxamide | Drug Info |
| Ftase --- FPTase | 4-(3-Chloro-phenyl)-6-[1-(4-chloro-phenyl)-1-(3-methyl-3H-imidazol-4-yl)-ethyl]-1-methyl-1H-quinolin-2-one | Drug Info |
| Ftase --- FPTase | 1-[4-(3,8-Dichloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-2-pyridin-4-yl-ethanone | Drug Info |
| Ftase --- FPTase | (S)-4-Carbamoyl-2-({(S)-2-[(S)-2-(2-3H-imidazol-4-yl-acetylamino)-3,3-dimethyl-butyryl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-butyric acid | Drug Info |
| Ftase --- FPTase | 17-benzyl-15,18-dioxo-(17R)-2-oxa-9,11,16,19-tetraazapentacyclo[18.6.2.13,7.09,13.024,28]nonacosa-1(27),3,5,7(29),10,12,20(28),21,23,25-decaen-4-yl cyanide | Drug Info |
| Ftase --- FPTase | (R)-17-Acetyl-2-bromo-6-chloro-17-hydroxy-10,13-dimethyl-16-methylene-1,2,8,9,10,11,12,13,14,15,16,17-dodecahydro-cyclopenta[a]phenanthren-3-one | Drug Info |
| Ftase --- FPTase | 15,16-dimethyl-17-oxo-(16R)-2-oxa-9,11,15,18-tetraazapentacyclo[17.6.2.13,7.09,13.023,27]octacosa-1(26),3,5,7(28),10,12,19(27),20,22,24-decaen-4-yl cyanide | Drug Info |
| Ftase --- FPTase | 4-methyl-23-oxo-8-oxa-1,15,17,21-tetraazapentacyclo[19.2.2.13,7.19,13.015,19]heptacosa-3(27),4,6,9(26),10,12,16,18-octaen-10-yl cyanide | Drug Info |
| Ftase --- FPTase | N-[7-Bromo-1-(3H-imidazol-4-ylmethyl)-4-methanesulfonyl-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-3-ylmethyl]-benzamide | Drug Info |
| Ftase --- FPTase | 4-[1-Amino-1-(3-methyl-3H-imidazol-4-yl)-ethyl]-2-[3-(1-methyl-2-oxo-azepan-3-yl)-phenoxy]-benzonitrile | Drug Info |
| Ftase --- FPTase | 4'-(2-Amino-3-mercapto-propylamino)-2'-propoxy-biphenyl-3-carboxylic acid 13 (FTI-288) | Drug Info |
| Ftase --- FPTase | 2-[4-((R)-2-Amino-3-mercapto-propylamino)-2-naphthalen-1-yl-benzoylamino]-4-methyl-pentanoic acid | Drug Info |
| Ftase --- FPTase | 1-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidin-1-yl]-2-[1-(2-morpholin-4-yl-2-oxo-ethyl)-piperidin-4-yl]-ethanone | Drug Info |
| Ftase --- FPTase | [2-((2E,6E)-3,7,11-Trimethyl-dodeca-2,6,10-trienylcarbamoyl)-ethyl]-phosphonic acid | Drug Info |
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-N-cyano-N'-(4-trifluoromethoxy-phenyl)-piperidine-1-carboxamidine | Drug Info |
| Ftase --- FPTase | (S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-naphthalene-1-carbonyl]-amino}-4-methylsulfanyl-butyric acid methyl ester | Drug Info |
| Ftase --- FPTase | N-[6-Cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-N-thiophen-3-ylmethyl-benzenesulfonamide | Drug Info |
| Ftase --- FPTase | 4-(2,3-dihydroxypropyl)-23-oxo-8-oxa-1,15,17,21-tetraazapentacyclo[19.2.2.13,7.19,13.015,19]heptacosa-3(27),4,6,9(26),10,12,16,18-octaen-10-yl cyanide | Drug Info |
| Ftase --- FPTase | 2-[3-(3-Ethyl-1-methyl-2-oxo-azepan-3-yl)-phenoxy]-4-imidazol-1-ylmethyl-benzonitrile | Drug Info |
| Ftase --- FPTase | (S)-2-[((S)-2-{(S)-2-[(S)-2-((R)-2,6-Diamino-hexanoylamino)-2-mercapto-acetylamino]-3-methyl-butyryl}-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl)-amino]-4-methylsulfanyl-butyric acid | Drug Info |
| Ftase --- FPTase | 1-[(2R,3R)-3-(2-Chloro-thiophen-3-ylmethoxy)-5-fluoro-2,3-dihydro-benzo[b]thiophen-2-ylmethyl]-1H-imidazole | Drug Info |
| Ftase --- FPTase | 4-(5-{[2-(3-Methoxy-phenyl)-3-oxo-2,3,4,5-tetrahydro-1H-benzo[c]azepin-4-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile | Drug Info |
| Ftase --- FPTase | 4-[3-(4-Cyano-benzyl)-2-methyl-3H-imidazol-4-ylmethyl]-piperazine-1-carboxylic acid 2-ethoxy-benzyl ester | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-3-nitro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-2-pyridin-4-yl-ethanone | Drug Info |
| Ftase --- FPTase | 6-[(3-chloro-4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-3'-methoxy-biphenyl-3-carbonitrile | Drug Info |
| Ftase --- FPTase | (S)-2-{[5-((R)-2-Amino-3-mercapto-propionylamino)-5,6,7,8-tetrahydro-naphthalene-1-carbonyl]-amino}-4-methylsulfanyl-butyric acid | Drug Info |
| Ftase --- FPTase | 2-(Biphenyl-2-yloxy)-4-imidazol-1-ylmethyl-benzonitrile | Drug Info |
| Ftase --- FPTase | 6-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-5-(3-methoxy-phenyl)-1-methyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile | Drug Info |
| Ftase --- FPTase | 15-benzyl-16-methyl-17-oxo-(16R)-2-oxa-9,11,15,18-tetraazapentacyclo[17.6.2.13,7.09,13.023,27]octacosa-1(26),3,5,7(28),10,12,19(27),20,22,24-decaen-4-yl cyanide | Drug Info |
| Ftase --- FPTase | ((2E,6E)-1-Hydroxy-3,7,11-trimethyl-dodeca-2,6,10-trienyl)-phosphonic acid | Drug Info |
| Ftase --- FPTase | 4-(2,2-dimethyl-1,3-dioxolan-4-ylmethyl)-23-oxo-8-oxa-1,15,17,21-tetraazapentacyclo[19.2.2.13,7.19,13.015,19]heptacosa-3(27),4,6,9(26),10,12,16,18-octaen-10-yl cyanide | Drug Info |
| Ftase --- FPTase | 6-(((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methoxy)methyl)-4'-(trifluoromethoxy)biphenyl-3-carbonitrile | Drug Info |
| Ftase --- FPTase | 16,18-dimethyl-17-oxo-(16R)-2-oxa-9,11,15,18-tetraazapentacyclo[17.6.2.13,7.09,13.023,27]octacosa-1(26),3,5,7(28),10,12,19(27),20,22,24-decaen-4-yl cyanide | Drug Info |
| Ftase --- FPTase | 6-{4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-2-[(pyridin-3-ylmethyl)-carbamoyl]-piperazin-1-yl}-6-oxo-hexanoic acid methyl ester | Drug Info |
| Ftase --- FPTase | 1-[4-(3,8-Dichloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidin-1-yl]-2-pyridin-3-yl-ethanone | Drug Info |
| Ftase --- FPTase | 8-[Amino-(4-chloro-phenyl)-(3-methyl-3H-imidazol-4-yl)-methyl]-6-(3-chloro-phenyl)-1,2-dihydro-pyrrolo[3,2,1-ij]quinolin-4-one | Drug Info |
| Ftase --- FPTase | 6-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-5-(3-fluoro-phenyl)-1-methyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile | Drug Info |
| Ftase --- FPTase | 4-Imidazol-1-ylmethyl-2-(4-phenyl-butoxy)-benzonitrile | Drug Info |
| Ftase --- FPTase | (S)-2-{(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propylamino)-3-methyl-pentylamino]-3-methyl-pentanoylamino}-4-methylsulfanyl-butyric acid | Drug Info |
| Ftase --- FPTase | 4-(5-{[2-(2-Methyl-benzyl)-3-oxo-2,3,4,5-tetrahydro-1H-benzo[c]azepin-4-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile | Drug Info |
| Ftase --- FPTase | 1-[(1R,2R)-1-(2-Chloro-thiophen-3-ylmethoxy)-1,2,6,7,8,9-hexahydro-naphtho[2,1-b]thiophen-2-ylmethyl]-1H-imidazole | Drug Info |
| Ftase --- FPTase | 1-[4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-(1-methyl-piperidin-4-yl)-ethanone | Drug Info |
| Ftase --- FPTase | Lithium; (S)-2-({5-[5-(4-dimethylamino-phenyl)-furan-2-ylmethoxymethyl]-2'-methyl-biphenyl-2-carbonyl}-amino)-4-methylsulfanyl-butyrate | Drug Info |
| Ftase --- FPTase | 4'-((R)-2-Amino-3-mercapto-propylamino)-biphenyl-3-carboxylic acid | Drug Info |
| Ftase --- FPTase | 1-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidine-3-carboxylic acid (pyridin-3-ylmethyl)-amide | Drug Info |
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-N-(4-dimethylamino-benzyl)-N'-cyano-piperidine-1-carboxamidine | Drug Info |
| Ftase --- FPTase | 4-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-3-(3,3-dimethyl-butyl)-benzonitrile | Drug Info |
| Ftase --- FPTase | 2-(3-Benzyl-phenoxy)-4-imidazol-1-ylmethyl-benzonitrile | Drug Info |
| Ftase --- FPTase | 4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-pentanoyl-piperazine-2-carboxylic acid (pyridin-3-ylmethyl)-amide | Drug Info |
| Ftase --- FPTase | (S)-2-({5-[2-((E)-5-Benzyl-pyridin-3-yl)-vinyl]-2'-methyl-biphenyl-2-carbonyl}-amino)-4-methylsulfanyl-butyric acid | Drug Info |
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