Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| PI3K gamma --- PI3K delta | 2-(6-(1-benzyl-1H-pyrazol-4-yl)-2H-benzo[b][1,4]oxazin-4(3H)-yl)-6,6-dimethyl-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| PI3K gamma --- PI3K delta | 2-(2,3-dihydrobenzo[b][1,4]oxazin-4-yl)-5,5-dimethyl-5,6-dihydrobenzo[d]thiazol-7(4H)-one | Drug Info |
| PI3K gamma --- PI3K delta | 2-(6-(6-methoxypyridazin-3-yl)-2H-benzo[b][1,4]oxazin-4(3H)-yl)-6,6-dimethyl-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| PI3K gamma --- PI3K delta | 4-(Difluoromethoxy)-2-(difluoromethyl)-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]-1H-benzimidazole | Drug Info |
| PI3K gamma --- PI3K delta | 2-(6-(5-amino-1-methyl-1H-pyrazol-4-yl)-2H-benzo[b][1,4]oxazin-4(3H)-yl)-6,6-dimethyl-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| PI3K gamma --- PI3K delta | 2-(7-bromo-2,3-dihydrobenzo[b][1,4]oxazin-4-yl)-5,5-dimethyl-5,6-dihydrobenzo[d]thiazol-7(4H)-one | Drug Info |
| PI3K gamma --- PI3K delta | 2-Morpholin-4-yl-10-naphthalen-1-ylmethyl-10H-benzo[4,5]imidazo[1,2-a]pyrimidin-4-one | Drug Info |
| PI3K gamma --- PI3K delta | henicosa-4,7,10,12,15,18-hexaenoic acid | Drug Info |
| PI3K gamma --- PI3K delta | 6,6-dimethyl-2-(6-(1-(pyridin-3-ylmethyl)-1H-pyrazol-4-yl)-2H-benzo[b][1,4]oxazin-4(3H)-yl)-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| PI3K gamma --- PI3K delta | 1-(2,3-dichlorobenzyl)-7-(2-methylmorpholino)imidazo[1,2-a]pyrimidin-5(1H)-one | Drug Info |
| PI3K gamma --- PI3K delta | 5,5-dimethyl-2-(6-(pyridin-2-yl)-2,3-dihydrobenzo[b][1,4]oxazin-4-yl)-5,6-dihydrobenzo[d]thiazol-7(4H)-one | Drug Info |
| PI3K gamma --- PI3K delta | (S)-2-(3-((1H-indol-3-yl)methyl)morpholino)-5,5-dimethyl-5,6-dihydrobenzo[d]thiazol-7(4H)-one | Drug Info |
| PI3K gamma --- PI3K delta | 2-((4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-methyl-3-o-tolylquinazolin-4(3H)-one | Drug Info |
| PI3K gamma --- PI3K delta | 1-(2,3-dichlorobenzyl)-6-fluoro-7-morpholinoimidazo[1,2-a]pyrimidin-5(1H)-one | Drug Info |
| PI3K gamma --- PI3K delta | 2-(4-(2-methyl-8-(2-(pyridin-3-yl)ethynyl)-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)propanenitrile | Drug Info |
| PI3K gamma --- PI3K delta | 3-((4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)ethynyl)phenol | Drug Info |
| PI3K gamma --- PI3K delta | 2-(6-(4,6-dimethylpyridazin-3-ylamino)-2H-benzo[b][1,4]oxazin-4(3H)-yl)-6,6-dimethyl-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| PI3K gamma --- PI3K delta | 2-(6-cyclopropyl-2,3-dihydrobenzo[b][1,4]oxazin-4-yl)-6,6-dimethyl-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| PI3K gamma --- PI3K delta | (3aS,5bS,6S,11bR)-6-Methoxymethyl-3a,5b-dimethyl-1,3a,4,5b,6,11b-hexahydro-2H-7,10-dioxa-cyclopenta[j]acephenanthrylene-3,5,8,11-tetraone | Drug Info |
| PI3K gamma --- PI3K delta | 2-(6-(1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl)-2H-benzo[b][1,4]oxazin-4(3H)-yl)-6,6-dimethyl-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| PI3K gamma --- PI3K delta | 2-(2,3-dihydropyrido[2,3-b][1,4]oxazin-1-yl)-5,5-dimethyl-5,6-dihydrobenzo[d]thiazol-7(4H)-one | Drug Info |
| PI3K gamma --- PI3K delta | 2-(6-(1-ethyl-1H-pyrazol-4-yl)-2H-benzo[b][1,4]oxazin-4(3H)-yl)-6,6-dimethyl-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| PI3K gamma --- PI3K delta | Acetic acid (2R,3aS,5R,5bR,6S,11bR)-2-acetoxy-6-methoxymethyl-3a,5b-dimethyl-3,8,11-trioxo-2,3,3a,4,5,5b,11,11b-octahydro-1H,6H,8H-7,10-dioxa-cyclopenta[j]acephenanthrylen-5-yl ester | Drug Info |
| PI3K gamma --- PI3K delta | N-(6-(4-amino-1-((2-(4-methylpiperazin-1-yl)quinolin-3-yl)methyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)benzo[d]thiazol-2-yl)acetamide | Drug Info |
| PI3K gamma --- PI3K delta | Acetic acid (3aS,5R,5bR,6S,12bR)-6-methoxymethyl-3a,5b-dimethyl-3,8,12-trioxo-2,3,3a,4,5,5b,8,10,12,12b-decahydro-1H,6H-7,11-dioxa-benzo[fg]cyclopenta[a]anthracen-5-yl ester | Drug Info |
| PI3K gamma --- PI3K delta | 2-(6-(1H-pyrazol-4-yl)-2,3-dihydrobenzo[b][1,4]oxazin-4-yl)-5,5-dimethyl-5,6-dihydrobenzo[d]thiazol-7(4H)-one | Drug Info |
| PI3K gamma --- PI3K delta | 6-Amino-2-(difluoromethyl)-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]-4-methoxy-1H-benzimidazole | Drug Info |
| PI3K gamma --- PI3K delta | Acetic acid (2R,3aS,5R,5bR,6S,11bR)-2-bromo-6-methoxymethyl-3a,5b-dimethyl-3,8,11-trioxo-2,3,3a,4,5,5b,11,11b-octahydro-1H,6H,8H-7,10-dioxa-cyclopenta[j]acephenanthrylen-5-yl ester | Drug Info |
| PI3K gamma --- PI3K delta | 6,6-dimethyl-2-(6-(6-methylpyridazin-3-yl)-2H-benzo[b][1,4]oxazin-4(3H)-yl)-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| PI3K gamma --- PI3K delta | 6,6-dimethyl-2-(6-(1-methyl-1H-imidazol-2-yl)-2,3-dihydrobenzo[b][1,4]oxazin-4-yl)-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| PI3K gamma --- PI3K delta | 2-(4-(8-(pyridin-3-ylethynyl)-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)acetonitrile | Drug Info |
| PI3K gamma --- PI3K delta | 2-(Difluoromethyl)-4-hydroxy-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]-1H-benzimidazole | Drug Info |
| PI3K gamma --- PI3K delta | 5,5-dimethyl-2-(6-(pyridin-3-yl)-2,3-dihydrobenzo[b][1,4]oxazin-4-yl)-5,6-dihydrobenzo[d]thiazol-7(4H)-one | Drug Info |
| PI3K gamma --- PI3K delta | 1-(2-methyl-3-(trifluoromethyl)benzyl)-7-morpholinoimidazo[1,2-a]pyrimidin-5(1H)-one | Drug Info |
| PI3K gamma --- PI3K delta | 6,6-dimethyl-2-(6-(6-(4-methylpiperazin-1-yl)pyridazin-3-yl)-2H-benzo[b][1,4]oxazin-4(3H)-yl)-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| PI3K gamma --- PI3K delta | 6,6-dimethyl-2-(6-(6-methylpyridin-3-yl)-2,3-dihydrobenzo[b][1,4]oxazin-4-yl)-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| PI3K gamma --- PI3K delta | 2-(6-(1H-imidazol-5-yl)-2,3-dihydrobenzo[b][1,4]oxazin-4-yl)-6,6-dimethyl-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| PI3K gamma --- PI3K delta | 2-(6-(6-(dimethylamino)pyridazin-3-yl)-2H-benzo[b][1,4]oxazin-4(3H)-yl)-6,6-dimethyl-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| PI3K gamma --- PI3K delta | 1-(2,3-dichlorobenzyl)-7-(2-(hydroxymethyl)morpholino)imidazo[1,2-a]pyrimidin-5(1H)-one | Drug Info |
| PI3K gamma --- PI3K delta | (R)-1-(2-methyl-3-(trifluoromethyl)benzyl)-7-(2-methylmorpholino)imidazo[1,2-a]pyrimidin-5(1H)-one | Drug Info |
| PI3K gamma --- PI3K delta | CHEMBL1957845 | Drug Info |
| PI3K gamma --- PI3K delta | 2-(morpholin-4-yl)-6,7-dihydro-4H-spiro[1,3-benzothiazole-5,1'-cyclohexane]-7-one | Drug Info |
| PI3K gamma --- PI3K delta | 3-(6-(1H-indazol-5-ylamino)-2-morpholinopyrimidin-4-yl)phenol | Drug Info |
| PI3K gamma --- PI3K delta | N-(3-(3,5-dimethoxyphenylamino)quinoxalin-2-yl)-4-fluorobenzenesulfonamide | Drug Info |
| PI3K gamma --- PI3K delta | 1-(4-((2-(2-Aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxyethanone | Drug Info |
| PI3K gamma --- PI3K delta | 2-(6-bromo-2,3-dihydrobenzo[b][1,4]oxazin-4-yl)-5,5-dimethyl-5,6-dihydrobenzo[d]thiazol-7(4H)-one | Drug Info |
| PI3K gamma --- PI3K delta | 6,6-dimethyl-2-(6-(6-(4-methylpiperazin-1-yl)pyridazin-3-ylamino)-2H-benzo[b][1,4]oxazin-4(3H)-yl)-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| PI3K gamma --- PI3K delta | 1-(2,3-dichlorobenzyl)-7-(2,2-dimethylmorpholino)imidazo[1,2-a]pyrimidin-5(1H)-one | Drug Info |
| PI3K gamma --- PI3K delta | 2-(6-acetyl-2,3-dihydrobenzo[b][1,4]oxazin-4-yl)-6,6-dimethyl-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| PI3K gamma --- PI3K delta | 3-[6-(4-Methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-2-yl]-phenol | Drug Info |
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