Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| PI3K gamma --- PI3K delta | 2-(6-(6-methoxypyridazin-3-ylamino)-2H-benzo[b][1,4]oxazin-4(3H)-yl)-6,6-dimethyl-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| PI3K gamma --- PI3K delta | CHEMBL1213085 | Drug Info |
| PI3K gamma --- PI3K delta | 2-(7-fluoro-2,3-dihydrobenzo[b][1,4]oxazin-4-yl)-6,6-dimethyl-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| PI3K gamma --- PI3K delta | (3aS,5bR,6S)-6-Methoxymethyl-3a,5b-dimethyl-1,2,3a,4,5b,6,11a,11b-octahydro-7,10-dioxa-cyclopenta[j]acephenanthrylene-3,8,11-trione | Drug Info |
| PI3K gamma --- PI3K delta | 5,5-dimethyl-2-(6-phenyl-2,3-dihydrobenzo[b][1,4]oxazin-4-yl)-5,6-dihydrobenzo[d]thiazol-7(4H)-one | Drug Info |
| PI3K gamma --- PI3K delta | 2-(6-(1-(2-hydroxy-2-methylpropyl)-3,5-dimethyl-1H-pyrazol-4-yl)-2H-benzo[b][1,4]oxazin-4(3H)-yl)-6,6-dimethyl-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| PI3K gamma --- PI3K delta | 2-(6-(1H-pyrazol-5-yl)-2,3-dihydrobenzo[b][1,4]oxazin-4-yl)-6,6-dimethyl-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| PI3K gamma --- PI3K delta | CHEMBL1645107 | Drug Info |
| PI3K gamma --- PI3K delta | 2-(2,3-dihydrobenzo[b][1,4]oxazin-4-yl)-6,6-dimethyl-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| PI3K gamma --- PI3K delta | 2-(6-(6-aminopyridazin-3-yl)-2H-benzo[b][1,4]oxazin-4(3H)-yl)-6,6-dimethyl-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| PI3K gamma --- PI3K delta | 5-[6-(4-Methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-ylthieno[3,2-d]pyrimidin-2-yl]-pyridin-2-ylamine | Drug Info |
| PI3K gamma --- PI3K delta | 2-methyl-2-(4-(3-methyl-2-oxo-8-(pyridin-3-ylethynyl)-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)propanenitrile | Drug Info |
| PI3K gamma --- PI3K delta | CHEMBL1213118 | Drug Info |
| PI3K gamma --- PI3K delta | Acetic acid (3aS,5R,5bR,6S,11bR)-5-acetoxy-6-methoxymethyl-3a,5b-dimethyl-8,11-dioxo-3a,4,5,5b,11,11b-hexahydro-1H,6H,8H-7,10-dioxa-cyclopenta[j]acephenanthrylen-3-yl ester | Drug Info |
| PI3K gamma --- PI3K delta | TG100-115 | Drug Info |
| PI3K gamma --- PI3K delta | 1-(2,3-dichlorobenzyl)-2-methyl-7-morpholinoimidazo[1,2-a]pyrimidin-5(1H)-one | Drug Info |
| PI3K gamma --- PI3K delta | 2-(6-(3,5-dimethyl-1H-pyrazol-4-yl)-2H-benzo[b][1,4]oxazin-4(3H)-yl)-6,6-dimethyl-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| PI3K gamma --- PI3K delta | (3-(6-((4-(Methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinothieno[3,2-d]pyrimidin-2-yl)phenyl)methanol | Drug Info |
| PI3K gamma --- PI3K delta | 2-(6-(1H-pyrazol-4-yl)-2H-benzo[b][1,4]oxazin-4(3H)-yl)-6,6-dimethyl-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| PI3K gamma --- PI3K delta | 6-(4-Methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-2-pyridin-4-yl-thieno[3,2-d]pyrimidine | Drug Info |
| PI3K gamma --- PI3K delta | 4-[6-(4-Methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-ylthieno[3,2-d]pyrimidin-2-yl]-phenylamine | Drug Info |
| PI3K gamma --- PI3K delta | Acetic acid (1S,10R,11R,13S,14R)-4-diethylaminomethylene-6-hydroxy-1-methoxymethyl-10,13-dimethyl-3,7,17-trioxo-1,3,4,7,10,11,12,13,14,15,16,17-dodecahydro-2-oxa-cyclopenta[a]phenanthren-11-yl ester | Drug Info |
| PI3K gamma --- PI3K delta | Phosphoric acid (R)-2-imidazol-1-yl-3-octadecyloxy-propyl ester (1S,2S,3S)-2,3,4,6-tetrahydroxy-5-hydroxymethyl-cyclohexyl ester | Drug Info |
| PI3K gamma --- PI3K delta | 2-(6-(1,3-dimethyl-1H-pyrazol-4-yl)-2H-benzo[b][1,4]oxazin-4(3H)-yl)-6,6-dimethyl-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| PI3K gamma --- PI3K delta | (S)-10-Hydroxy-3a,6-dimethyl-3-oxo-1,3,3a,10b-tetrahydro-2H-9-oxa-dicyclopenta[a,g]naphthalene-7-carboxylic acid methyl ester | Drug Info |
| PI3K gamma --- PI3K delta | CHEMBL1957851 | Drug Info |
| PI3K gamma --- PI3K delta | 2-(6-bromo-2,3-dihydrobenzo[b][1,4]oxazin-4-yl)-6,6-dimethyl-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| PI3K gamma --- PI3K delta | 1-(2,3-dichlorobenzyl)-7-thiomorpholinoimidazo[1,2-a]pyrimidin-5(1H)-one | Drug Info |
| PI3K gamma --- PI3K delta | 2-(6-(1-benzyl-1H-pyrazol-4-yl)-2H-benzo[b][1,4]oxazin-4(3H)-yl)-6,6-dimethyl-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| PI3K gamma --- PI3K delta | 2-(2,3-dihydrobenzo[b][1,4]oxazin-4-yl)-5,5-dimethyl-5,6-dihydrobenzo[d]thiazol-7(4H)-one | Drug Info |
| PI3K gamma --- PI3K delta | 2-(6-(6-methoxypyridazin-3-yl)-2H-benzo[b][1,4]oxazin-4(3H)-yl)-6,6-dimethyl-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| PI3K gamma --- PI3K delta | 4-(Difluoromethoxy)-2-(difluoromethyl)-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]-1H-benzimidazole | Drug Info |
| PI3K gamma --- PI3K delta | 2-(6-(5-amino-1-methyl-1H-pyrazol-4-yl)-2H-benzo[b][1,4]oxazin-4(3H)-yl)-6,6-dimethyl-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| PI3K gamma --- PI3K delta | 2-(7-bromo-2,3-dihydrobenzo[b][1,4]oxazin-4-yl)-5,5-dimethyl-5,6-dihydrobenzo[d]thiazol-7(4H)-one | Drug Info |
| PI3K gamma --- PI3K delta | 2-Morpholin-4-yl-10-naphthalen-1-ylmethyl-10H-benzo[4,5]imidazo[1,2-a]pyrimidin-4-one | Drug Info |
| PI3K gamma --- PI3K delta | henicosa-4,7,10,12,15,18-hexaenoic acid | Drug Info |
| PI3K gamma --- PI3K delta | 6,6-dimethyl-2-(6-(1-(pyridin-3-ylmethyl)-1H-pyrazol-4-yl)-2H-benzo[b][1,4]oxazin-4(3H)-yl)-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| PI3K gamma --- PI3K delta | 1-(2,3-dichlorobenzyl)-7-(2-methylmorpholino)imidazo[1,2-a]pyrimidin-5(1H)-one | Drug Info |
| PI3K gamma --- PI3K delta | 5,5-dimethyl-2-(6-(pyridin-2-yl)-2,3-dihydrobenzo[b][1,4]oxazin-4-yl)-5,6-dihydrobenzo[d]thiazol-7(4H)-one | Drug Info |
| PI3K gamma --- PI3K delta | (S)-2-(3-((1H-indol-3-yl)methyl)morpholino)-5,5-dimethyl-5,6-dihydrobenzo[d]thiazol-7(4H)-one | Drug Info |
| PI3K gamma --- PI3K delta | 2-((4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-methyl-3-o-tolylquinazolin-4(3H)-one | Drug Info |
| PI3K gamma --- PI3K delta | 1-(2,3-dichlorobenzyl)-6-fluoro-7-morpholinoimidazo[1,2-a]pyrimidin-5(1H)-one | Drug Info |
| PI3K gamma --- PI3K delta | 2-(4-(2-methyl-8-(2-(pyridin-3-yl)ethynyl)-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)propanenitrile | Drug Info |
| PI3K gamma --- PI3K delta | 3-((4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)ethynyl)phenol | Drug Info |
| PI3K gamma --- PI3K delta | 2-(6-(4,6-dimethylpyridazin-3-ylamino)-2H-benzo[b][1,4]oxazin-4(3H)-yl)-6,6-dimethyl-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| PI3K gamma --- PI3K delta | 2-(6-cyclopropyl-2,3-dihydrobenzo[b][1,4]oxazin-4-yl)-6,6-dimethyl-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| PI3K gamma --- PI3K delta | (3aS,5bS,6S,11bR)-6-Methoxymethyl-3a,5b-dimethyl-1,3a,4,5b,6,11b-hexahydro-2H-7,10-dioxa-cyclopenta[j]acephenanthrylene-3,5,8,11-tetraone | Drug Info |
| PI3K gamma --- PI3K delta | 2-(6-(1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl)-2H-benzo[b][1,4]oxazin-4(3H)-yl)-6,6-dimethyl-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| PI3K gamma --- PI3K delta | 2-(2,3-dihydropyrido[2,3-b][1,4]oxazin-1-yl)-5,5-dimethyl-5,6-dihydrobenzo[d]thiazol-7(4H)-one | Drug Info |
| PI3K gamma --- PI3K delta | 2-(6-(1-ethyl-1H-pyrazol-4-yl)-2H-benzo[b][1,4]oxazin-4(3H)-yl)-6,6-dimethyl-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
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