Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Erbeta --- ER | 9a-ethyl-6-(4-hydroxy-phenyl)-8,9,9a,10-tetrahydro-3H-1,2,3-triaza-cyclopenta[a]fluoren-7-one | Drug Info |
| JNK1 --- JNK3 | methyl 3-(2-(thiophen-2-yl)acetamido)thiophene-2-carboxylate | Drug Info |
| PR --- mRNA of AR | 3-fluoro-5-(2,2,4-trimethyl-1,2-dihydroquinolin-6-yl)benzonitrile | Drug Info |
| Erbeta --- ER | SID48410359 | Drug Info |
| MEP --- Cathepsin B | (S)-3-Methyl-2-(3-phenyl-thioureido)-pentanoic acid [(R)-1-formyl-2-(1H-indol-3-yl)-ethyl]-amide | Drug Info |
| PR --- mRNA of AR | 5-Bromo-2-((1S,2R,4R)-2,4-dimethyl-6-methylene-cyclohexylmethyl)-4-methoxy-phenol | Drug Info |
| Erbeta --- ER | SID87347952 | Drug Info |
| MEP --- Cathepsin B | benzyl (S)-1-((S)-4-fluoro-3-oxo-1-phenylbutan-2-ylamino)-1-oxo-3-phenylpropan-2-ylcarbamate | Drug Info |
| PR --- mRNA of AR | (R)-2-chloro-4-((1-methylpyrrolidin-3-yl)(2-(trifluoromethyl)benzyl)amino)benzonitrile | Drug Info |
| Erbeta --- ER | (E)-3-Chloro-4-(3-fluoro-4-hydroxyphenyl)salicylaldoxime | Drug Info |
| MEP --- Cathepsin B | (S)-4-Methyl-2-(4''-piperazin-1-yl-biphenyl-2-ylamino)-pentanoic acid cyanomethyl-amide | Drug Info |
| PR --- mRNA of AR | 5-Butyl-2,2,4,9-tetramethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene | Drug Info |
| Erbeta --- ER | 11-[4-(1-Hydroxy-3-piperidin-1-yl-propyl)-phenyl]-benzo[b]naphtho[2,3-d]thiophene-3,9-diol | Drug Info |
| MEP --- Cathepsin B | N-((S)-3-(naphthalen-2-yl)-1-oxo-1-((S)-3-oxo-1-(pyridin-2-ylsulfonyl)azepan-4-ylamino)propan-2-yl)-1-naphthamide | Drug Info |
| PR --- mRNA of AR | racemic-5-chloro-6-(5-fluoro-1H-indol-7-yl)-2,2,4,8-tetramethyl-1,2,3,4-tetrahydroquinoline | Drug Info |
| Erbeta --- ER | 8-Chloro-3-(3-fluoro-4-hydroxy-phenyl)-7-hydroxy-naphthalene-1-carbonitrile | Drug Info |
| MEP --- Cathepsin B | (S)-N-((R)-Benzyloxymethyl-cyano-methyl)-2-phenylamino-3-m-tolyl-propionamide | Drug Info |
| PR --- mRNA of AR | (8S,10R,13S,14S,17S)-17-Hydroxy-13-methyl-10-(4-methyl-benzyl)-17-prop-1-ynyl-1,2,6,7,8,10,12,13,14,15,16,17-dodecahydro-cyclopenta[a]phenanthren-3-one | Drug Info |
| Erbeta --- ER | {2-(4-Hydroxy-phenyl)-3-[4-(2-piperidin-1-yl-ethoxy)-benzoyl]-benzo[b]thiophen-6-yl}-phosphonic acid diethyl ester | Drug Info |
| Met --- VEGFR | 1-(4-(2-(1-ethyl-1H-imidazol-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-3-(2-phenylacetyl)thiourea | Drug Info |
| PR --- mRNA of AR | (S)-5-allyl-10-ethynyl-2,2,4-trimethyl-2,5-dihydro-1H-chromeno[3,4-f]quinoline | Drug Info |
| Erbeta --- ER | 6-bromo-9a-ethyl-8,9,9a,10-tetrahydro-3H-1,2,3-triaza-cyclopenta[a]fluoren-7-one | Drug Info |
| Met --- VEGFR | SID174006531 | Drug Info |
| PR --- mRNA of AR | [2-Chloro-5-(4-{[(2,4-difluoro-benzyl)-(3-methanesulfonylamino-2-methyl-phenyl)-amino]-methyl}-phenoxy)-phenoxy]-acetic acid | Drug Info |
| Erbeta --- ER | 8-Fluoro-6-(3-fluoro-4-hydroxy-phenyl)-naphthalen-2-ol | Drug Info |
| Met --- VEGFR | N-(3-fluoro-4-(2-(pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenylcarbamothioyl)-2-phenylacetamide | Drug Info |
| Renin --- Cathepsin D | 2-[2-(Morpholine-4-sulfonylamino)-3-phenyl-propionylamino]-pent-4-enoic acid [1-cyclohexylmethyl-3,3-difluoro-3-(2-methyl-butylcarbamoyl)-2-oxo-propyl]-amide | Drug Info |
| Erbeta --- ER | [6-Hydroxy-2-(4-hydroxy-phenyl)-benzo[b]thiophen-3-yl]-[4-(2-piperidin-1-yl-ethylsulfanyl)-phenyl]-methanone | Drug Info |
| MMP1 --- MMP3 | (R)-2-((S)-4-(3-hydroxyphenyl)-1-((S)-4-methyl-1-oxo-1-(phenylamino)pentan-2-ylamino)-1-oxobutan-2-ylamino)propanoic acid | Drug Info |
| S5AR --- SRD5A2 | 4-Methyl-3-oxo-2,3,5,6-tetrahydro-1H-pyrido[1,2-a]quinoline-8-carboxylic acid 4-amino-phenyl ester | Drug Info |
| Erbeta --- ER | 2-(4-Isopropyl-phenyl)-1-methyl-1-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-1,2,3,4-tetrahydro-isoquinolin-6-ol | Drug Info |
| MMP1 --- MMP3 | (R)-N*1*-((S)-2,2-Dimethyl-1-methylcarbamoyl-propyl)-2-[4-(4-fluoro-phenoxy)-butyl]-N*4*-hydroxy-succinamide | Drug Info |
| S5AR --- SRD5A2 | 4-Methyl-3-oxo-2,3,5,6-tetrahydro-1H-pyrido[1,2-a]quinoline-8-carboxylic acid ethyl ester | Drug Info |
| Erbeta --- ER | 4-(6-hydroxy-1-(4-(2-(piperidin-1-yl)ethoxy)phenoxy)naphthalen-2-yl)-N,N-dimethylbenzenesulfonamide | Drug Info |
| MMP1 --- MMP3 | (S)-3-(4-Fluoro-phenyl)-N-methyl-2-[3-(5-thioxo-4,5-dihydro-[1,3,4]thiadiazol-2-yl)-ureido]-propionamide | Drug Info |
| S5AR --- SRD5A2 | (1S,9aR,11aS)-9a,11a-Dimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxylic acid (5-bromo-2-tert-butyl-phenyl)-amide | Drug Info |
| Erbeta --- ER | 9a-butyl-7-hydroxy-4-(thiophen-2-yl)-1,2,9,9a-tetrahydrofluoren-3-one | Drug Info |
| MMP1 --- MMP9 | (R)-2-((S)-1-Dimethylcarbamoyl-3-methyl-butylamino)-4-(1,3-dioxo-1,3-dihydro-benzo[f]isoindol-2-yl)-butyric acid | Drug Info |
| S5AR --- SRD5A2 | (10R,13S,17S)-17-[1-(4-Chloro-phenyl)-cyclopentylcarbamoyl]-10,13-dimethyl-2,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3-carboxylic acid | Drug Info |
| Erbeta --- ER | (E)-3-[4-((7R,13S,17S)-3,17-Dihydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-7-ylsulfanyl)-phenyl]-acrylic acid | Drug Info |
| MMP13 --- MMP1 | 1-Acetyl-4-(4-but-2-ynyloxy-benzenesulfonyl)-7-morpholin-4-yl-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-3-carboxylic acid hydroxyamide | Drug Info |
| S5AR --- SRD5A2 | 4-Chloro-17-diisopropylcarbamoyl-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3-carboxylic acid | Drug Info |
| Erbeta --- ER | (13S,17S)-2-(2-Hydroxy-ethyl)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol | Drug Info |
| MMP13 --- MMP1 | 4-(4-Phenoxy-benzenesulfonylamino)-tetrahydro-pyran-4-carboxylic acid hydroxyamide | Drug Info |
| S5AR --- SRD5A2 | (1S,3aS,3bS,9aR,9bS,11aS)-5-cyano-N,N-diethyl-9a,11a-dimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxamide | Drug Info |
| Erbeta --- ER | 8-Bromo-7-hydroxy-3-(4-hydroxy-phenyl)-naphthalene-1-carbonitrile | Drug Info |
| MMP13 --- MMP1 | 8-bromo-4-(4-(but-2-ynyloxy)-N-methylphenylsulfonamido)-N-hydroxyquinoline-3-carboxamide | Drug Info |
| S5AR --- SRD5A2 | (1S,9aR,11aS)-9a,11a-Dimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxylic acid (2,5-bis-trifluoromethyl-phenyl)-amide | Drug Info |
| Erbeta --- ER | 1-Ethyl-2-(4-hydroxy-phenyl)-3H-inden-5-ol | Drug Info |
| MMP13 --- MMP1 | (3S,6S)-4-(4-(but-2-ynyloxy)phenylsulfonyl)-N-hydroxy-6-(2-hydroxyethyl)-2,2-dimethylthiomorpholine-3-carboxamide | Drug Info |
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