Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Src --- VEGFR | N-(2-chloro-5-methoxyphenyl)-5-isopropoxy-7-(3-morpholinopropoxy)quinazolin-4-amine | Drug Info |
| Ftase --- FPTase | 4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-N-cyano-N'-pyridin-2-ylmethyl-piperidine-1-carboxamidine | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(4-methyl-1H-indol-5-ylamino)-5-styrylnicotinonitrile | Drug Info |
| VEGFR1 --- FGFR1 | 2-(1H-indazol-3-yl)-5-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazole | Drug Info |
| Ftase --- FPTase | (S)-2-{(4E,8E)-2-[Benzenesulfonyl-(3-methyl-3H-imidazol-4-ylmethyl)-amino]-5,9,13-trimethyl-tetradeca-4,8,12-trienoylamino}-3-phenyl-propionic acid | Drug Info |
| NPKCdelta --- NPKCtheta | (E)-5-(2-(6-((4-(2-hydroxyethyl)piperazin-1-yl)methyl)pyridin-2-yl)vinyl)-4-(4-methyl-1H-indol-5-ylamino)nicotinonitrile | Drug Info |
| VEGFR2 --- AuroraA | 7-(5-(3-(4-hydroxypiperidin-1-yl)propoxy)-1H-indol-2-yl)isoindolin-1-one | Drug Info |
| Ftase --- FPTase | (S)-2-{(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propionylamino)-3-methyl-butyrylamino]-4-methyl-pentanoylamino}-3-hydroxy-propionic acid | Drug Info |
| NPKCdelta --- NPKCtheta | 4-(4-methyl-1H-indol-5-ylamino)-5-(2-(2-(pyrrolidin-1-yl)ethoxy)styryl)nicotinonitrile | Drug Info |
| VEGFR2 --- CDK1 | 2-(4-(4-(4-(2-aminopropan-2-yl)phenyl)-5-chloropyrimidin-2-ylamino)phenyl)ethanol | Drug Info |
| FTase --- GTase | (E)-N-[3-Benzoyl-4-(2-p-tolyl-acetylamino)-phenyl]-3-phenyl-acrylamide | Drug Info |
| CDK1 --- CDK2 | 4-(5-(diethylamino)-[1,2,4]triazolo[1,5-a]pyrimidin-7-ylamino)benzenesulfonamide | Drug Info |
| NPKCdelta --- NPKCtheta | 5-(4-(2-(2-(dimethylamino)ethylamino)ethoxy)phenyl)-4-(4-methyl-1H-indol-5-ylamino)nicotinonitrile | Drug Info |
| VEGFR2 --- CDK1 | 3-(4-(methoxymethyl)-1H-benzo[d]imidazol-2-yl)-5-(pyridin-3-yl)-1H-pyrazolo[3,4-b]pyridine | Drug Info |
| H3 --- SERT | (6S,10bR)-6-(4-(1H-imidazol-1-yl)phenyl)-9-(3-morpholinopropoxy)-1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinoline | Drug Info |
| EGFR3 --- HER2 | 2-(4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)-1H-pyrazolo[3,4-d]pyrimidin-3-yloxy)ethanol | Drug Info |
| PI3K gamma --- PI3K delta | 2-(7-fluoro-2,3-dihydrobenzo[b][1,4]oxazin-4-yl)-6,6-dimethyl-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| VEGFR2 --- Ckit | (3S,9S)-9,16-dihydroxy-14-methoxy-3-methyl-3,4,9,10,11,12-hexahydro-1H-benzo[c][1]oxacyclotetradecine-1,7(8H)-dione | Drug Info |
| H3 --- SERT | 7-(3-(4-fluoropiperidin-1-yl)propoxy)-4-(3-methoxyphenyl)-2-methyl-1,2,3,4-tetrahydroisoquinoline | Drug Info |
| EGFR3 --- HER2 | 4-(4-bromo-3-methylphenylamino)-6,7-dimethoxyquinoline-3-carbonitrile | Drug Info |
| PI3K gamma --- PI3K delta | (3aS,5bR,6S)-6-Methoxymethyl-3a,5b-dimethyl-1,2,3a,4,5b,6,11a,11b-octahydro-7,10-dioxa-cyclopenta[j]acephenanthrylene-3,8,11-trione | Drug Info |
| VEGFR2 --- Cmet | N-(3-fluoro-4-(2-(4-((2-(methylsulfonyl)ethylamino)methyl)phenyl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-1-phenyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxamide | Drug Info |
| H3 --- SERT | 4-(4-(difluoromethoxy)phenyl)-7-(3-(4-fluoropiperidin-1-yl)propoxy)-2-methyl-1,2,3,4-tetrahydroisoquinoline | Drug Info |
| EGFR3 --- HER2 | 1-(3,5-Dibromo-2-hydroxybenzyl)-1-(4-fluorobenzyl)-3-phenylthiourea | Drug Info |
| PI3K gamma --- PI3K delta | 5,5-dimethyl-2-(6-phenyl-2,3-dihydrobenzo[b][1,4]oxazin-4-yl)-5,6-dihydrobenzo[d]thiazol-7(4H)-one | Drug Info |
| VEGFR2 --- Cmet | N-(3-fluoro-4-(2-(pyrrolidine-1-carbonyl)thieno[3,2-b]pyridin-7-yloxy)phenylcarbamothioyl)-2-phenylacetamide | Drug Info |
| H3 --- SERT | N,N-dimethyl-3-(4-(4-(piperidin-1-yl)but-1-ynyl)phenyl)-3-(4-(trifluoromethyl)phenoxy)propan-1-amine | Drug Info |
| EGFR3 --- HER2 | 2-(5-(4-Bromophenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)thiazol-4(5H)-one | Drug Info |
| PI3K gamma --- PI3K delta | 2-(6-(1-(2-hydroxy-2-methylpropyl)-3,5-dimethyl-1H-pyrazol-4-yl)-2H-benzo[b][1,4]oxazin-4(3H)-yl)-6,6-dimethyl-6,7-dihydrothiazolo[5,4-c]pyridin-4(5H)-one | Drug Info |
| VEGFR2 --- Cmet | rac-N-(3-Fluoro-4-(7-methoxyquinolin-4-yloxy)phenyl)-1-(2-hydroxypropyl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide | Drug Info |
| HD6 --- HDAC4 | N-(cyclohexylmethyl)-4-(2,2,2-trifluoroacetyl)thiophene-2-carboxamide | Drug Info |
| EGFR3 --- HER2 | AC-480 | Drug Info |
| PKCA --- NPKC delta | 5-(2,2-Dimethyl-propoxymethyl)-5-hydroxymethyl-3-[3-isobutyl-5-methyl-hex-(E)-ylidene]-dihydro-furan-2-one | Drug Info |
| VEGFR2 --- CSrc | 4-{1-[(Benzyloxy)methyl]-1H-indol-3-yl}-3-(3,4,5-trimethoxyphenyl)-1,5-dihydro-2H-pyrrole-2-one | Drug Info |
| HDAC1 --- HD6 | 6-((5S,8S,11S)-11-((1H-indol-3-yl)methyl)-2,2-dimethyl-8-(naphthalen-1-ylmethyl)-3,6,9,13-tetraoxo-1,4,7,10-tetraazacyclotridecan-5-yl)hexanoic acid | Drug Info |
| EGFR3 --- HER2 | 2-(2-(4-Methoxybenzylidene)hydrazinyl)thiazol-4(5H)-one | Drug Info |
| PKCA --- NPKC delta | 4-(2-Carboxy-6-hydroxy-benzoyl)-3,5-dihydroxy-benzoic acid (1R,2R)-2-(4-hydroxy-benzoylamino)-cycloheptyl ester | Drug Info |
| VEGFR2 --- CSrc | N-(4-methyl-3-(1-(6-(2-(pyrrolidin-2-yl)ethylamino)pyrimidin-4-yl)-1H-benzo[d]imidazol-2-ylamino)phenyl)-3-(trifluoromethyl)benzamide | Drug Info |
| HDAC1 --- HD6 | 3-(4-(((2-(1H-indol-2-yl)ethyl)(2-hydroxyethyl)amino)methyl)phenyl)-N-hydroxyacrylamide | Drug Info |
| EGFR3 --- HER2 | (3-Chloro-4-fluoro-phenyl)-{6-[2-(2-methanesulfonyl-ethylamino)-thiazol-4-yl]-quinazolin-4-yl}-amine | Drug Info |
| PKCA --- NPKC delta | 4-(2-Carboxy-6-hydroxy-benzoyl)-3,5-dihydroxy-benzoic acid (1R,2R)-2-(4-hydroxy-benzoylamino)-4-methylcarbamoyl-cyclopentyl ester | Drug Info |
| VEGFR2 --- CSrc | [6-Methoxy-7-(3-morpholin-4-yl-propoxy)-quinazolin-4-yl]-(1-methyl-1H-indol-4-yl)-amine | Drug Info |
| HDAC1 --- HD6 | (R)-3-(3-(1-(1-ethylpiperidin-3-yl)-4,5-dimethyl-1H-imidazol-2-yl)phenyl)-N-hydroxyacrylamide | Drug Info |
| EGFR3 --- HER2 | N-[4-[(3-chloro-4-fluorophenyl)amino]pyrido[3,4-d]pyrimidin-6-yl]-4-(bis(1-methylethyl)amino)-2-butynamide | Drug Info |
| PPAR gamma --- 5LOX | 2-(4-(3-(2,3-dimethylphenoxy)propoxy)phenylthio)hexanoic acid | Drug Info |
| VEGFR2 --- CSrc | isobutyl4-(7-amino-3-(3-(4-methylpiperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-6-yl)-3-methylphenylcarbamate | Drug Info |
| HDAC1 --- HD6 | 2-Phenoxyethyl 2-(4-methoxyphenyl)-2-oxoethyl trithiocarbonate | Drug Info |
| EGFR3 --- HER2 | N4-(3-(6-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)pyrimidin-4-yloxy)phenyl)pyrimidine-4,6-diamine | Drug Info |
| PPAR gamma --- mRNA of PTP1B | (S)-7-(2-{2-[(1E)-1,5-Dimethylhexen-1-yl]-5-methyloxazol-4-yl}ethoxy)-2-[(2E,4E)-hexadienoyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid tert-butylamine salt | Drug Info |
| VEGFR2 --- FGFR1 | 1-(1-tert-Butyl-1H-pyrazol-4-yl)-3-{2-chloro-4-[(5-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yl)oxy]phenyl}urea | Drug Info |
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