Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Erbeta --- ER | 2-(3-Isopropyl-phenyl)-1-methyl-1-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-1,2,3,4-tetrahydro-isoquinolin-6-ol | Drug Info |
| PR --- mRNA of AR | 4-methyl-5-(2,2,4-trimethyl-1,2-dihydroquinolin-6-yl)thiophene-2-carbonitrile | Drug Info |
| MMP1 --- MMP3 | 1-[(S)-1-Benzyl-2-oxo-2-(4-pyridin-2-yl-piperazin-1-yl)-ethyl]-3-(5-thioxo-4,5-dihydro-[1,3,4]thiadiazol-2-yl)-urea | Drug Info |
| Erbeta --- ER | 5-Bromo-2-(4-hydroxy-phenyl)-quinolin-6-ol | Drug Info |
| PR --- mRNA of AR | 5-(4,4-dimethyl-2-oxo-2,4-dihydro-1H-benzo[d][1,3]oxazin-6-yl)-2-fluorobenzonitrile | Drug Info |
| MMP1 --- MMP3 | 3-[(S)-2-((R)-2-Hydroxycarbamoylmethyl-6-phenoxy-hexanoylamino)-3,3-dimethyl-butyrylamino]-propionic acid | Drug Info |
| Erbeta --- ER | (E)-4,4'-dihydroxybiphenyl-3-carbaldehyde oxime | Drug Info |
| PR --- mRNA of AR | rac-3-(4-Nitrophenylamino)-1-(3-bromophenyl)-3-(3-fluorophenyl)propan-1-one | Drug Info |
| MMP1 --- MMP9 | (3R,6S)-6-Benzyl-1-butyl-3-mercaptomethyl-piperazine-2,5-dione | Drug Info |
| Erbeta --- ER | 4-((1R,2R,5R)-5-Hydroxymethyl-8-methyl-3-oxa-bicyclo[3.3.1]non-7-en-2-yl)-benzene-1,3-diol | Drug Info |
| Renin --- Cathepsin D | 2-[2-(Morpholine-4-sulfonylamino)-3-phenyl-propionylamino]-pent-4-enoic acid (1-cyclohexylmethyl-4-[1,3]dithian-2-yl-2,4-dihydroxy-butyl)-amide | Drug Info |
| MMP13 --- MMP1 | 2-(4-(4-fluorophenoxy)phenylsulfonamido)-N-hydroxy-2-methylpropanamide | Drug Info |
| Erbeta --- ER | (4-{4-[6-Hydroxy-2-(4-hydroxy-phenyl)-benzo[b]thiophene-3-carbonyl]-phenyl}-piperazin-1-yl)-o-tolyl-methanone | Drug Info |
| Renin --- Cathepsin D | 8-(3-(2-fluoropyridin-3-yl)phenyl)-8-(4-(trifluoromethoxy)phenyl)-4,8-dihydro-3H-imidazo[5,1-c][1,2,4]oxadiazin-6-amine | Drug Info |
| MMP13 --- MMP1 | 4-[(R)-Carboxy-(5-phenylthiophene-2-sulfonylamino)-methyl]-piperidine-1-carboxylic Acid tert-Butyl Ester | Drug Info |
| Erbeta --- ER | CHEMBL410193 | Drug Info |
| S5AR --- SRD5A2 | (1S,9aR,11aS)-9a,11a-Dimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxylic acid (3,5-di-tert-butyl-phenyl)-amide | Drug Info |
| MMP13 --- MMP1 | (4-Benzyl-benzyl)-[3-cyclohexyl-2-((R)-2,2-dimethyl-1-methylcarbamoyl-propylcarbamoyl)-propyl]-phosphinic acid | Drug Info |
| Erbeta --- ER | Strobopinin | Drug Info |
| S5AR --- SRD5A2 | (4aR,10bR)-4,10b-Dimethyl-8-((E)-2-quinolin-3-yl-vinyl)-1,4,4a,5,6,10b-hexahydro-2H-benzo[f]quinolin-3-one | Drug Info |
| MMP13 --- MMP1 | (3S,4R)-3-Hydroxy-4-(4-m-tolyloxy-benzenesulfonyl)-tetrahydro-pyran-3-carboxylic acid hydroxyamide | Drug Info |
| Erbeta --- ER | 3-(4-hydroxy-phenyl)-1-propyl-1,2,3,4-tetrahydro-quinolin-7-ol | Drug Info |
| S5AR --- SRD5A2 | (1S,10aR,12aS)-10a,12a-Dimethyl-8-oxo-1,2,3,3a,3b,4,5,6,8,9,10,10a,10b,11,12,12a-hexadecahydro-benzo[b]indeno[5,4-d]azepine-1-carboxylic acid diethylamide | Drug Info |
| MMP13 --- MMP1 | 1-Acetyl-4-(4-but-2-ynyloxy-benzenesulfonyl)-7-dimethylamino-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-3-carboxylic acid hydroxyamide | Drug Info |
| Erbeta --- ER | 4,6-dibromo-2-(3-fluoro-4-hydroxyphenyl)-7-vinylbenzo[d]oxazol-5-ol | Drug Info |
| S5AR --- SRD5A2 | (1S,3aS,3bS,9aR,9bS,11aS)-methyl 9a,11a-dimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxylate | Drug Info |
| MMP13 --- MMP14 | 5-Amino-3-[4-(2-chloro-phenoxy)-phenoxy]-3-(2-ethoxy-ethyl)-piperidine-2,4,6-trione | Drug Info |
| Erbeta --- ER | 2-(4-Hydroxy-phenyl)-4-methoxy-quinolin-6-ol | Drug Info |
| S5AR --- SRD5A2 | (1S,3aS,3bS,9aR,9bS,11aS)-N-tert-butyl-5,9a,11a-trimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxamide | Drug Info |
| MMP13 --- MMP3 | N-Hydroxy-N-[2-[4-(2-methyl-quinolin-4-ylmethoxy)-benzenesulfonyl]-1-(4-oxo-cyclohexylmethyl)-ethyl]-formamide | Drug Info |
| Erbeta --- ER | (2S,3R)-5-Fluoro-3-(4-hydroxy-phenyl)-2-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-2,3-dihydro-benzo[1,4]oxathiin-6-ol | Drug Info |
| S5AR --- SRD5A2 | (1S,3aS,3bS,9aR,9bS,11aS)-N-(2-tert-butyl-5-(trifluoromethyl)phenyl)-9a,11a-dimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[i]phenanthridine-1-carboxamide | Drug Info |
| MMP2 --- HER2 | (2S,3S,5RS)-N-hydroxy-1-methyl-5-(2-oxo-2-(pyrrolidin-1-yl)ethyl)-2-(4-phenylpiperazine-1-carbonyl)piperidine-3-carboxamide | Drug Info |
| Erbeta --- ER | 11-((7S,13S,17S)-3,17-Dihydroxy-13-methyl-6-oxo-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-7-ylsulfanyl)-undecanoic acid butyl-methyl-amide | Drug Info |
| S5AR --- SRD5A2 | 6-Benzyloxy-5-methoxy-1-methyl-1H-indole-2-carboxylic acid | Drug Info |
| MMP2 --- MMP1 | N-[2-(4,4-Dimethyl-2,5-dioxo-imidazolidin-1-yl)-1-(4'-methanesulfonyl-biphenyl-4-yloxymethyl)-ethyl]-N-hydroxy-formamide | Drug Info |
| Erbeta --- Mcl1 | SID4241330 | Drug Info |
| ABL --- Src | 4-[2-(4-Amino-5-phenyl-pyrrolo[2,3-d]pyrimidin-7-yl)-3-hydroxy-propyl]-phenol | Drug Info |
| MMP2 --- MMP13 | (S)-3-Methyl-2-{4'-[(3-phenyl-benzofuran-2-carbonyl)-amino]-biphenyl-4-sulfonylamino}-butyric acid | Drug Info |
| Ftase --- FPTase | 4-(5-{[3-(2-Chloro-benzyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[d]azepin-1-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile | Drug Info |
| ABL --- Src | 4-(7-(2-chloro-6-hydroxyphenyl)-5-methylbenzo[e][1,2,4]triazin-3-ylamino)-N-(2-(pyrrolidin-1-yl)ethyl)benzenesulfonamide | Drug Info |
| MMP2 --- MMP13 | (R)-N-hydroxy-3-methyl-2-(naphthalene-2-sulfonamido)butanamide | Drug Info |
| Ftase --- FPTase | (S)-2-[3-({[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-amino}-methyl)-benzoylamino]-4-methylsulfanyl-butyric acid methyl ester | Drug Info |
| ABL --- Src | 4-(2-Chloro-phenylamino)-6,7-dimethoxy-quinoline-3-carbonitrile | Drug Info |
| MMP2 --- MMP13 | (S)-2-{4'-[(5-Ethyl-4-isopropoxy-3-methyl-benzofuran-2-carbonyl)-amino]-biphenyl-4-sulfonylamino}-3-methyl-butyric acid | Drug Info |
| Ftase --- FPTase | (S)-3-Hydroxy-2-[(S)-2-((S)-2-{2-[hydroxy-((2E,6E)-3,7,11-trimethyl-dodeca-2,6,10-trienyl)-phosphinoyloxy]-acetylamino}-3-methyl-butyrylamino)-4-methyl-pentanoylamino]-propionic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-(7-methyl-9H-carbazol-3-yl)ethanone | Drug Info |
| MMP2 --- MMP13 | (S)-2-(4'-(4-(3-methoxypropyl)-3-methylbenzofuran-2-carboxamido)biphenyl-4-ylsulfonamido)-3-methylbutanoic acid | Drug Info |
| Ftase --- FPTase | 5-(3-Chloro-phenyl)-6-[(4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-2-oxo-1,2-dihydro-pyridine-3-carbonitrile | Drug Info |
| TRIP5 --- mRNA of KIF11 | (S)-1-(3-(2,5-difluorophenyl)-5-phenyl-4,5-dihydropyrazol-1-yl)ethanone | Drug Info |
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