Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| PKCA --- NPKC delta | [2-(Hydroxymethyl)-4-(methylethylidene)-5-oxo-2-2,3-dihydrofuryl]methyl 4-(4-[2-(4-Methylphenyl)ethynyl]phenoxy)butanoate | Drug Info |
| VEGFR2 --- VEGFR1 | (2-((1H-indazol-6-yl)methylamino)phenyl)(1H-indazol-3-yl)methanone | Drug Info |
| HDAC1 --- HD6 | 2-[4-(Acetylamino-methyl)-phenyl]-2-oxoethyl Ethyl Trithiocarbonate | Drug Info |
| EGFR3 --- HER2 | N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-(5-((dimethylamino)methyl)furan-2-yl)thieno[3,2-d]pyrimidin-4-amine | Drug Info |
| PKCA --- NPKC delta | 18-benzylaminomethyl-(18S)-17-oxa-4,14,21-triazahexacyclo[19.6.1.17,14.02,6.08,13.022,27]nonacosa-1(28),2(6),7(29),8(13),9,11,22(27),23,25-nonaene-3,5-dione | Drug Info |
| VEGFR2 --- VEGFR1 | 2-((5H-imidazo[4,5-c]pyridin-5-yl)methyl)-N-(4-morpholinophenyl)benzamide | Drug Info |
| HDAC1 --- HD6 | (S)-benzyl 1-(5-phenyl-1,3,4-oxadiazol-2-yl)-5-(sulfamoylamino)pentylcarbamate | Drug Info |
| EGFR3 --- HER2 | N-(4-(3-bromophenylamino)-3-cyano-7-methoxyquinolin-6-yl)but-2-ynamide | Drug Info |
| PKCA --- NPKC delta | 4-(2-Carboxy-6-hydroxy-benzoyl)-3,5-dihydroxy-benzoic acid (1R,2R)-4-acetyl-2-(4-hydroxy-benzoylamino)-cyclopentyl ester | Drug Info |
| VEGFR2 --- VEGFR1 | 4-Acetyl-N-(2,4-dichloro-benzoyl)-benzenesulfonamide | Drug Info |
| HDAC1 --- HD6 | (S)-benzyl 1-(6-methoxyquinolin-8-ylamino)-1-oxo-6-(sulfamoylamino)hexan-2-ylcarbamate | Drug Info |
| EGFR3 --- HER2 | (E)-3-(3-Benzylsulfanylmethyl-4-hydroxy-5-methoxy-phenyl)-2-cyano-acrylamide | Drug Info |
| PPAR delta --- LXRalpha | 2-(4-(methyl(3-(7-propyl-3-(trifluoromethyl)benzo[d]isoxazol-6-yloxy)propyl)amino)-2-(trifluoromethyl)phenyl)acetic acid | Drug Info |
| VEGFR2 --- VEGFR1 | N-(4-isopropylphenyl)-5-(3-(2-(pyridin-4-yl)ethyl)pyridin-4-yl)-1,3,4-oxadiazol-2-amine | Drug Info |
| HDAC1 --- HD6 | (S)-benzyl 1-(4-(4-isopropylphenyl)thiazol-2-ylamino)-1-oxo-6-(sulfamoylamino)hexan-2-ylcarbamate | Drug Info |
| EGFR3 --- HER2 | (R)-N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-(pyrrolidin-2-ylethynyl)thieno[3,2-d]pyrimidin-4-amine | Drug Info |
| PPAR gamma --- mRNA of PTP1B | (S)-2-[(2E,4E)]-Hexadienoyl]-7-(2-{2-[(1E)-3,3-dimethylbuten-1-yl]-5-methyloxazol-4-yl}ethoxy)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid tert-butylamine salt | Drug Info |
| HDAC1 --- HD6 | Clarithromycin-N-benzyltriazolylheptahydroxamic Acid | Drug Info |
| EGFR3 --- HER2 | N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-(5-((ethylamino)methyl)-1H-pyrrol-2-yl)thieno[2,3-d]pyrimidin-4-amine | Drug Info |
| PPAR gamma --- PPAR delta | 2-(2,3-dimethyl-4-(2-((5-methylisoxazol-3-yl)methoxy)-4-((4-(trifluoromethyl)phenoxy)methyl)phenylthio)phenoxy)acetic acid | Drug Info |
| HDAC1 --- HDAC2 | 4-((3,4-dimethoxyphenylamino)methyl)-N-(2-hydroxyphenyl)benzamide | Drug Info |
| EGFR3 --- VEGFR1 | 2-(2-{4-[7-(1H-Indol-5-ylamino)-thieno[3,2-b]pyridin-2-yl]-benzylamino}-ethoxy)-ethanol | Drug Info |
| PPAR gamma --- PPAR delta | 2-{5-[4-(7-propyl-3-trifluoromethylbenzo[d]isoxazol-6-yloxy)butoxy]-1H-indol-1-yl}ethanoic acid | Drug Info |
| HDAC1 --- HDAC2 | N-(2-amino-5-(thiophen-3-yl)phenyl)-4-((3,4-dimethoxyphenylamino)methyl)benzamide | Drug Info |
| Erbeta --- ER | 4-(5-phenyl-2-(trifluoromethyl)-1H-imidazol-4-yl)phenol | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-(N-butyl-N-(4'-chloro-4-methylbiphenyl-3-yl)sulfamoyl)-2,3-dimethylphenoxy)propanoic acid | Drug Info |
| HDAC1 --- HDAC2 | 8-[2-(4-Bromo-phenyl)-oxazol-5-yl]-2-oxo-octanoic acid methylamide | Drug Info |
| Erbeta --- ER | 4-[1-(4-Dimethylaminomethoxy-phenyl)-2-phenyl-but-1-enyl]-phenol | Drug Info |
| PPAR gamma --- PPAR delta | (E)-2-(2-methyl-4-(1-(((4-methyl-2-(4-(trifluoromethyl)-phenyl)thiazol-5-yl)methoxy)imino)butyl)phenoxy)acetic acid | Drug Info |
| HDAC1 --- HDAC2 | 1,1,1-Trifluoro-8-phenoxy-octan-2-one | Drug Info |
| Erbeta --- ER | (Z)-4-[4-(2-Dimethylamino-ethoxy)-phenyl]-3,4-diphenyl-but-3-en-1-ol | Drug Info |
| PPAR gamma --- PPAR delta | 3-(4-(3-((5-chloro-1H-indole-2-carboxamido)methyl)phenoxy)-2-methylphenyl)propanoic acid | Drug Info |
| HDAC1 --- HDAC2 | 7-[1-Biphenyl-4-yl-meth-(Z)-ylideneaminooxy]-2-oxo-heptanoic acid methylamide | Drug Info |
| Erbeta --- ER | (2-Benzo[1,3]dioxol-5-yl-6-methoxy-benzo[b]thiophen-3-yl)-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone | Drug Info |
| PPAR gamma --- PPAR delta | (S)-2-(4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benzyl)-2-phenoxybutanoic acid | Drug Info |
| HDAC1 --- HDAC4 | (S)-N-cyclopentyl-7-mercapto-2-pivalamidoheptanamide | Drug Info |
| Erbeta --- ER | [5-Hydroxy-2-(4-hydroxy-phenyl)-benzofuran-7-yl]-acetonitrile | Drug Info |
| PPAR gamma --- PPAR delta | 2-(4-(3-(2-benzoyl-4-ethylphenoxy)propoxy)phenoxy)-2-methylpropanoic acid | Drug Info |
| HER2 --- CD221 | cis-N-(4-(4-amino-1-(4-(4-(3-methoxypropyl)piperazin-1-yl)cyclohexyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenyl)-7-chlorobenzo[d]oxazol-2-amine | Drug Info |
| Erbeta --- ER | (2-Chloro-phenyl)-(4-{4-[6-hydroxy-2-(4-hydroxy-phenyl)-benzo[b]thiophene-3-carbonyl]-phenyl}-piperazin-1-yl)-methanone | Drug Info |
| PPAR gamma --- PPAR delta | 4-{4-[2-(3-Phenyl-7-propyl-benzo[d]isoxazol-6-yloxy)-ethoxy]-phenyl}-butyric acid | Drug Info |
| HER2 --- MMP-2 | (2S,3S)-N-hydroxy-5-(N-methylbenzamido)-2-(4-phenyl-1,2,3,6-tetrahydropyridine-1-carbonyl)piperidine-3-carboxamide | Drug Info |
| Erbeta --- ER | 3-(4-Hydroxy-phenyl)-4-methyl-2-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-2H-chromen-7-ol | Drug Info |
| PPAR gamma --- PPAR delta | (S)-5-(3-(3-(4-(4,4-difluorocyclohexyl)-2-propylphenoxy)propoxy)phenyl)oxazolidine-2,4-dione | Drug Info |
| JNK1 --- JNK3 | 5-cyano-6-ethoxy-pyridine-2-carboxylic acid 4-methanesulfonyl-benzylamide | Drug Info |
| Erbeta --- ER | 4-Ethyl-6-(3-fluoro-4-hydroxy-phenyl)-naphthalen-2-ol | Drug Info |
| PPAR gamma --- PPAR delta | 2-methyl-2-(2-methyl-4-(3-((2-methyl-4-(trifluoromethyl)benzamido)methyl)phenoxy)phenoxy)propanoic acid | Drug Info |
| JNK1 --- JNK3 | 9-cyclopentyl-N2-ethyl-N8-(2-fluorophenyl)-9H-purine-2,8-diamine | Drug Info |
| Erbeta --- ER | (3aS,4R,9bR)-6-(hydroxymethyl)-4-(4-hydroxyphenyl)-1,2,3,3a,4,9b-hexahydrocyclopenta[c]chromen-8-ol | Drug Info |
| PPAR gamma --- PPAR delta | 2-(2-methyl-4-(2-(3-morpholinoprop-1-ynyl)-6-(2-(4-(trifluoromethyl)phenyl)ethynyl)pyridin-4-ylthio)phenoxy)acetic acid | Drug Info |
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