Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| Erbeta --- ER | (6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)(4-(4-isopropylpiperazin-1-yl)phenyl)methanone | Drug Info |
| Met --- VEGFR | N-(3-fluoro-4-(2-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-2-oxo-3-phenylimidazolidine-1-carboxamide | Drug Info |
| Renin --- Cathepsin D | (1S,5S)-7-(4-(3-(2-chloro-3,6-difluorophenoxy)propyl)phenyl)-N-cyclopropyl-N-(2,3-dichlorobenzyl)-3,9-diazabicyclo[3.3.1]non-6-ene-6-carboxamide | Drug Info |
| Erbeta --- ER | (2-Biphenyl-4-yl-6-hydroxy-benzo[b]thiophen-3-yl)-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone | Drug Info |
| MMP1 --- MMP3 | 1,3-Bis-(4-methoxy-benzenesulfonyl)-[1,3]diazepane-2-carboxylic acid hydroxyamide | Drug Info |
| S5AR --- SRD5A2 | Bexlosteride | Drug Info |
| Erbeta --- ER | 3-(4-(3-butyl-2-(4-methoxyphenyl)naphthalen-1-yloxy)phenyl)acrylic acid | Drug Info |
| MMP1 --- MMP3 | N-hydroxy-2-[[diphenylphosphinyl]-(2-phenylethyl)-amino]-acetamide | Drug Info |
| S5AR --- SRD5A2 | 4-Methyl-3-oxo-2,3,5,6-tetrahydro-1H-pyrido[1,2-a]quinoline-8-carboxylic acid phenyl ester | Drug Info |
| Erbeta --- ER | 2-(4-hydroxyphenyl)-3-(4-(2-(piperidin-1-yl)ethoxy)phenoxy)benzo[b]thiophen-6-ol | Drug Info |
| MMP1 --- MMP3 | {(S)-3-[(R)-2-((R)-1-Hydroxycarbamoyl-ethyl)-decanoylamino]-2-oxo-azepan-1-yl}-acetic acid methyl ester | Drug Info |
| S5AR --- SRD5A2 | 17-(1-Hydroxyimino-ethyl)-10,13-dimethyl-1,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-2H-cyclopenta[a]phenanthrene-3,6-dione | Drug Info |
| Erbeta --- ER | 1-Chloro-6-(2-fluoro-4-hydroxy-phenyl)-naphthalen-2-ol | Drug Info |
| MMP1 --- MMP9 | 2-((2S,5R)-2-(4-nitrobenzyl)-5-(mercaptomethyl)-3,6-dioxopiperazin-1-yl)-N-tert-butyl-4-methylpentanamide | Drug Info |
| S5AR --- SRD5A2 | (8S,9S,10R,13S,14S,17S)-17-(diisopropylcarbamoyl)-4-fluoro-10,13-dimethyl-2,5,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3-carboxylic acid | Drug Info |
| Erbeta --- ER | 1-{2-[4-(4-Phenyl-2,3-dihydro-benzo[b]oxepin-5-yl)-phenoxy]-ethyl}-pyrrolidine | Drug Info |
| MMP13 --- MMP1 | (R)-[5-(4'-Methoxyphenyl)-thiophene-2-sulfonylamino]-[1-(benzenesulfonyl)-piperidin-4-yl]-acetic Acid | Drug Info |
| S5AR --- SRD5A2 | (4aR,6aS)-4a,6a-Dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxylic acid p-tolylamide | Drug Info |
| Erbeta --- ER | 5-[4-(3-Hydroxypropoxy)phenyl]-11,12-dihydro-5H-6,13-dioxabenzo[3,4]cyclohepta[1,2-a]naphthal ene-2,8-diol | Drug Info |
| MMP13 --- MMP1 | (S)-4-(4-(6-aminohex-2-ynyloxy)phenylsulfonyl)-N-hydroxy-2,2-dimethylthiomorpholine-3-carboxamide | Drug Info |
| S5AR --- SRD5A2 | N,N-Diethyl-2-(1,4a,6a-trimethyl-2-oxo-hexadecahydro-indeno[5,4-f]quinolin-7-yl)-acetamide | Drug Info |
| Erbeta --- ER | 3-Chloro-4-((1R,2R,5R)-5-hydroxymethyl-1,8-dimethyl-3-oxa-bicyclo[3.3.1]non-7-en-2-yl)-phenol | Drug Info |
| MMP13 --- MMP1 | 4-[4-(Naphthalen-1-yloxy)-benzenesulfonylamino]-tetrahydro-pyran-4-carboxylic acid hydroxyamide | Drug Info |
| S5AR --- SRD5A2 | 8-Methoxy-4a-methyl-3,4,4a,9-tetrahydro-phenanthrene-2-carboxylic acid | Drug Info |
| Erbeta --- ER | SID17510892 | Drug Info |
| MMP13 --- MMP1 | (S)-4-(4-butoxyphenylsulfonyl)-N-hydroxy-2,2-dimethylthiomorpholine-3-carboxamide | Drug Info |
| S5AR --- SRD5A2 | 4-Methyl-3-oxo-2,3,5,6-tetrahydro-1H-pyrido[1,2-a]quinoline-8-carboxylic acid isopropyl ester | Drug Info |
| Erbeta --- ER | (2S,3R)-3-(4-Hydroxy-phenyl)-2-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-2,3-dihydro-benzo[1,4]dithiin-6-ol | Drug Info |
| MMP13 --- MMP1 | 4-(4-But-2-ynyloxy-benzenesulfonyl)-1-(pyrazine-2-carbonyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine-3-carboxylic acid hydroxyamide | Drug Info |
| ABL --- Src | 6,7-Dimethoxy-4-(3,4,5-trimethoxy-phenoxy)-quinoline-3-carbonitrile | Drug Info |
| Erbeta --- ER | (R)-N-(4-(4-hydroxyphenyl)butan-2-yl)-2-(2-phenyl-5-(5-(piperidin-1-yl)pentyloxy)-1H-indol-3-yl)acetamide | Drug Info |
| MMP13 --- MMP14 | 5-Amino-3-[4-(4-bromo-phenoxy)-phenoxy]-3-(2-ethoxy-ethyl)-piperidine-2,4,6-trione | Drug Info |
| ABL --- Src | 4-(4-Chloro-2-iodo-phenylamino)-6,7-dimethoxy-quinoline-3-carbonitrile | Drug Info |
| Erbeta --- ER | 4-(2-{4-{[3-(4-Chloro-phenyl)-propyl]-methyl-amino}-6-[4-(2-phenyl-ethenesulfonyl)-piperazin-1-yl]-[1,3,5]triazin-2-ylamino}-ethyl)-phenol | Drug Info |
| MMP13 --- MMP3 | (R)-3-((S)-1-((S)-2-methoxy-1-phenylethylamino)-3,3-dimethyl-1-oxobutan-2-ylcarbamoyl)-6-(2-methylbiphenyl-4-yl)hexanoic acid | Drug Info |
| FGFR --- Src | 4-[3-(2,6-Dichloro-phenyl)-1-methyl-2-oxo-1,2-dihydro-[1,6]naphthyridin-7-ylamino]-N,N-diethyl-benzamide | Drug Info |
| Erbeta --- ER | CHEMBL1195345 | Drug Info |
| MMP2 --- HER2 | (2S,3S)-5-(2-(4-aminobutylamino)-2-oxoethyl)-N-hydroxy-2-(3-phenylpyrrolidine-1-carbonyl)piperidine-3-carboxamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 3-(2,5-difluorophenyl)-5-(4-(dimethylamino)butyl)-N-ethyl-5-phenyl-4,5-dihydropyrazole-1-carboxamide | Drug Info |
| Erbeta --- ER | 3,5-Dichloro-4-{(4S,5R)-5-[2-chloro-4-(2-piperidin-1-yl-ethoxy)-phenyl]-4,5-dihydro-1H-imidazol-4-yl}-phenol | Drug Info |
| MMP2 --- MMP1 | N-[1-(4'-Cyano-biphenyl-4-yloxymethyl)-2-(4,4-dimethyl-2,5-dioxo-imidazolidin-1-yl)-ethyl]-N-hydroxy-formamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-(1-(2,5-difluorophenyl)-4-(3-(methyl((3-methylisoxazol-5-yl)methyl)amino)propyl)-4-phenyl-4,5-dihydro-1H-pyrazol-3-yl)ethanone | Drug Info |
| Erbeta --- Mcl1 | SID843666 | Drug Info |
| MMP2 --- MMP13 | N-hydroxy-2-(4-(4-(trifluoromethoxy)phenoxy)piperidin-1-ylsulfonyl)benzamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | Adociasulfate-2 | Drug Info |
| Ftase --- FPTase | 2-{(R)-1-[4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidine-1-carbonyl]-3-methylsulfanyl-propyl}-isoindole-1,3-dione | Drug Info |
| MMP2 --- MMP13 | CHEMBL1940315 | Drug Info |
| TRIP5 --- mRNA of KIF11 | (R)-N-(3-aminopropyl)-N-(1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)-2-methylpropyl)-3-fluoro-4-methylbenzamide | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-11H-10-oxa-4-aza-dibenzo[a,d]cyclohepten-5-ylidene)-piperidin-1-yl]-2-(1-oxy-pyridin-4-yl)-ethanone | Drug Info |
| MMP2 --- MMP13 | 1-benzoyl-N-hydroxy-4-(4-((2-methylquinolin-4-yl)methoxy)phenylsulfonyl)piperidine-4-carboxamide | Drug Info |
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