Multi-target agents
| Target Pair | Drug Name | |
|---|---|---|
| TRIP5 --- mRNA of KIF11 | 9-methyl-2-(trifluoromethyl)-9H-carbazole | Drug Info |
| MMP2 --- MMP13 | (R)-3-tert-butoxy-N-hydroxy-2-(N-isopentylnaphthalene-2-sulfonamido)propanamide | Drug Info |
| Ftase --- FPTase | 1-[4-((R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidin-1-yl]-2-(1-methanesulfonyl-piperidin-4-yl)-ethanone | Drug Info |
| TRIP5 --- mRNA of KIF11 | (R)-2-(2-amino-3-(tritylthio)propanamido)acetic acid | Drug Info |
| MMP2 --- MMP3 | (2S,4R)-2-Butyl-6-(4'-carbamoyl-biphenyl-4-yl)-4-((S)-2,2-dimethyl-1-methylcarbamoyl-propylcarbamoyl)-hexanoic acid | Drug Info |
| Ftase --- FPTase | 8-Chloro-11-(1-(propylsulfonyl)piperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine | Drug Info |
| TRIP5 --- mRNA of KIF11 | 4-(7,8-dimethyl-4-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)-N,N-dimethylbutan-1-amine | Drug Info |
| MMP2 --- MMP3 | (R)-3-(((S)-3,3-dimethyl-1-oxo-1-((R)-1-phenylethylamino)butan-2-yl)carbamoyl)-6-phenylhexanoic acid | Drug Info |
| Ftase --- FPTase | (S)-2-(3-{[(1H-Imidazol-4-ylmethyl)-naphthalen-2-ylmethyl-amino]-methyl}-benzoylamino)-4-methylsulfanyl-butyric acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | (+/-)-3-amino-1-(1-(2-aminopyridin-4-yl)-6-chloro-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)propan-1-one | Drug Info |
| MMP2 --- MMP3 | (2S,4R)-2-Butyl-6-(4'-chloro-biphenyl-4-yl)-4-((S)-2,2-dimethyl-1-methylcarbamoyl-propylcarbamoyl)-hexanoic acid | Drug Info |
| Ftase --- FPTase | N-Dodecyl-2-phosphonomethyl-malonamic acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-(3-(2,5-difluorophenyl)-5-(thiophen-2-yl)-4,5-dihydropyrazol-1-yl)ethanone | Drug Info |
| MMP2 --- MMP3 | (2S,4R)-2-Butyl-6-(4'-dimethylcarbamoyl-biphenyl-4-yl)-4-((S)-2,2-dimethyl-1-methylcarbamoyl-propylcarbamoyl)-hexanoic acid | Drug Info |
| Ftase --- FPTase | N-(6-cyano-1-((1-methyl-1H-imidazol-5-yl)methyl)-1,2,3,4-tetrahydroquinolin-3-yl)-1-methyl-N-(2-methylallyl)-1H-imidazole-4-sulfonamide | Drug Info |
| TRIP5 --- mRNA of KIF11 | (+/-)-N-(3-(6-chloro-1-(3-hydroxyphenyl)-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)-3-oxopropyl)methanesulfonamide | Drug Info |
| MMP2 --- MMP9 | 5R,7S,8R)-8-[4-(2-methyl-quinolin-4-ylmethoxy)-benzoylamino]-1-oxa-spiro[4.4]nonane-7-carboxylic acid hydroxyamide | Drug Info |
| Ftase --- FPTase | (S)-2-[(2S,5R)-5-((R)-2-Amino-3-mercapto-propionylamino)-2-benzyl-6-methyl-heptanoylamino]-4-methylsulfanyl-butyric acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-(3-(2,5-difluorophenyl)-5-phenyl-4,5-dihydropyrazol-1-yl)ethanethione | Drug Info |
| MMP2 --- MMP9 | 5-(4-Butylpiperazin-1-yl)-5-(4-phenoxyphenyl)pyrimidine-2,4,6(1H,3H,5H)-trione | Drug Info |
| Ftase --- FPTase | 3-{[[3-(3,4-Dihydro-2H-quinoline-1-sulfonyl)-phenyl]-(3H-imidazol-4-ylmethyl)-amino]-methyl}-benzonitrile | Drug Info |
| TRIP5 --- mRNA of KIF11 | 1-(1-(3-hydroxyphenyl)-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)ethanone | Drug Info |
| MMP2 --- MMP9 | (S)-2-(benzyl(isopropyl)amino)-N-hydroxy-3-(N-(4-(4-(trifluoromethyl)phenoxy)phenyl)methan-2-ylsulfonamido)propanamide | Drug Info |
| Ftase --- FPTase | (S)-2-{3-[((R)-2-Amino-3-mercapto-propylamino)-methyl]-benzoylamino}-4-methylsulfanyl-butyric acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | (S)-2-cyclopropyl-1-((S)-4-(2,5-difluorophenyl)-2-(3-hydroxyphenyl)-2H-pyrrol-1(5H)-yl)-2-hydroxyethanone | Drug Info |
| MMP2 --- MMP9 | (S)-N-hydroxy-2-(4-phenylpiperidin-1-yl)-3-(N-(4-(4-(trifluoromethyl)phenoxy)phenyl)methan-2-ylsulfonamido)propanamide | Drug Info |
| Ftase --- FPTase | 4'-{[3-(4-Amino-benzyl)-3H-imidazol-4-ylmethyl]-amino}-[1,1';2',1'']terphenyl-3-carboxylic acid methyl ester 29 (FTI-2310) | Drug Info |
| TRIP5 --- mRNA of KIF11 | 4-((4aS,5R,10bS)-9-tert-butyl-3,4,4a,5,6,10b-hexahydro-2H-pyrano[3,2-c]quinolin-5-yl)-2-fluorophenol | Drug Info |
| MMP2 --- MMP9 | N-hydroxy-2-(N-(4-(p-tolyloxy)phenyl)methan-15-ylsulfonamido)acetamide | Drug Info |
| Ftase --- FPTase | 8-hydroxy-11-[2-(2-methoxyphenyl)acetyl]-1-phenyl-(1R,8S,9S,13S)-11-azatetracyclo[6.5.2.02,7.09,13]pentadeca-2,4,6-triene-9-carboxylic acid (RPR114235) | Drug Info |
| TRIP5 --- mRNA of KIF11 | (+/-)-1-(3-Hydroxyphenyl)-2-(p-aminobenzoyl)-6-methyl-1,2,3,4-tetrahydro-beta-carboline | Drug Info |
| MMP2 --- MMP9 | (R)-2-{4-[2-(4-Bromo-phenyl)-2H-tetrazol-5-yl]-benzenesulfonylamino}-3-(1H-indol-3-yl)-propionic acid | Drug Info |
| Ftase --- FPTase | (R)-2-({(S)-2-[(S)-2-((R)-2-Amino-3-mercapto-propylamino)-3,3-dimethyl-butyryl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-4-methanesulfonyl-butyric acid | Drug Info |
| TRIP5 --- mRNA of KIF11 | 4-(3-acetoxy-phenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethylester | Drug Info |
| MMP2 --- MMP9 | (3R,4S)-3-Hydroxycarbamoyl-4-[4-(2-methyl-quinolin-4-ylmethoxy)-phenylcarbamoyl]-piperidine-1-carboxylic acid isopropyl ester | Drug Info |
| Ftase --- FPTase | 1-[4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-piperidine-1-sulfonylmethyl]-7,7-dimethyl-bicyclo[2.2.1]heptan-2-ol | Drug Info |
| TRIP5 --- mRNA of KIF11 | 3-(7,8-dimethyl-4-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)propan-1-amine | Drug Info |
| MMP2 --- MMP9 | (S)-N-hydroxy-2-(4-hydroxypiperidin-1-yl)-3-(N-(4-(4-(trifluoromethyl)phenoxy)phenyl)methan-2-ylsulfonamido)propanamide | Drug Info |
| Ftase --- FPTase | 4-({[4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-N-cyano-piperidine-1-carboximidoyl]-amino}-methyl)-piperidine-1-carboxylic acid amide | Drug Info |
| TRIP5 --- mRNA of KIF11 | (+/-)-(1-(3-hydroxyphenyl)-6-methyl-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)(1-methylpiperidin-3-yl)methanone | Drug Info |
| MMP2 --- MMP9 | (R)-3-Phenyl-2-(4-phenylethynyl-benzenesulfonylamino)-propionic acid | Drug Info |
| Ftase --- FPTase | 4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1,2-dicarboxylic acid 1-cyclohexylamide 2-[(3-imidazol-1-yl-propyl)-amide] 1-cyclohexylamide 2-{[2-(1H-imidazol-4-yl)-ethyl]-amide} | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(3-aminopropyl)-N-(1-(3-benzyl-5-bromo-6-chloro-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)propyl)-4-methylbenzamide | Drug Info |
| MMP2 --- MMP9 | 2-(1,1-Dioxo-7-phenoxy-1,3,4,5-tetrahydro-1lambda*6*-benzo[f][1,2,5]thiadiazepin-2-yl)-N-hydroxy-propionamide | Drug Info |
| Ftase --- FPTase | 6-(3-Chloro-phenyl)-8-[(4-chloro-phenyl)-hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]-1,2-dihydro-pyrrolo[3,2,1-ij]quinolin-4-one | Drug Info |
| TRIP5 --- mRNA of KIF11 | N-(4'-bromo-3,3'-difluoro-4-biphenylyl)urea | Drug Info |
| MMP2 --- MMP9 | (R)-4-(4-chlorophenoxy)-N-(1-hydroxy-6-methyl-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl)benzenesulfonamide | Drug Info |
| Ftase --- FPTase | 1-{2-[3-(4-Cyano-benzyl)-3H-imidazol-4-yl]-acetyl}-5-naphthalen-1-yl-1,2,3,6-tetrahydro-pyridine-4-carbonitrile | Drug Info |
| HER2 --- VEGFR | 6-(4-methylpiperazin-1-yl)-2-(4-(2-(pyridin-3-yl)vinyl)-1H-pyrazol-3-yl)-1H-benzo[d]imidazole | Drug Info |
| MMP3 --- MMP8 | [2-(4'-Fluoro-biphenyl-4-sulfonyl)-3-hydroxycarbamoyl-1,2,3,4-tetrahydro-isoquinolin-7-yl]-carbamic acid tert-butyl ester | Drug Info |
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